2YQD


Conserved Protein Domain Family
Bromo_polybromo_V

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cd05515: Bromo_polybromo_V 
Click on image for an interactive view with Cn3D
Bromodomain, polybromo repeat V. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. It was shown that polybromo bromodomains bind to histone H3 at specific acetyl-lysine positions. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine, but not all the bromodomains in polybromo may bind to acetyl-lysine.
Statistics
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PSSM-Id: 99946
View PSSM: cd05515
Aligned: 14 rows
Threshold Bit Score: 168.252
Threshold Setting Gi: 7301208
Created: 13-Sep-2006
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
acetyllysine
Conserved site includes 6 residues -Click on image for an interactive view with Cn3D
Feature 1:acetyllysine binding site
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                        #    #  #                                      # 
2YQD_A         16 MQQKLNEVYEAVKNYTDKr-GRRLSAIFLRLPSRSELPDYYLTIKKPMDMEKIRSHMMANKYQDIDSMVEDFVMMFNNAC 94
gi 24370475   681 DKIKLYELYNLIRNYKDEr-GRELSLPFLQLPSKFDYPDYYDVIRRPIDLTKIRNRITSNYYDSTDALISDFNLMFDNAC 759
gi 7301208    641 ITERLWQFYETVKEYQEPkgKRQLSLIFTKLPSKSEYPDYYDIIREPIDMDRIAQKLKQGAYDTLDDLAADFLLMLENAC 720
gi 110765845  664 HLQKLKTMYDTIKDYHDGk-GRQLSLIFMKLPNKNEYPDYYEVIKQPMNMEKIASTLKNNGYENLDELVSDFILMFDNAC 742
gi 108884551  630 LESKLKHLYDTIREYREPkaNRQLSFIFMKLPSKNEYPDYYDIIKNPIDLERIEFKLRKQNYESVDDMAADFMLMFENAC 709
gi 18958139   710 EEQKMWRLFKSMKDVREEgtNRPLAVNFMRLPSKEEFPAYYDVIKKPMDMMRIKHKLENRQYVTLLDVVSDFMLMLSNAC 789
gi 54648598   681 MQHKLNEVYEAVKNYTDKr-GRRLSAIFLRLPSRSELPDYYVTIKRPIDMEKIRSHIMANKYQDLDAMCEDFVTMFNNAC 759
gi 68534308    71 LQQKLSELYEAVRNFTDNr-GRRLSTVFLRLPSRSELPDYYAAIKRPIDMERIRGYMVQGRYQDVDSLAEDFILMFNNAC 149
gi 115668674  706 LAQKLNELYNAIKNYTDQh-GRELSPPFIRLPSKNEYPEYYQVIKRPMDMQRIQQKIISRGYDQLEDMVNDFLLMFDNAC 784
gi 156363502  617 LKELCRELFNAVKDCTDGs-GRQLCIIFQKLPSRAEYPDYYTLIKKPIDMAKIQSKLNGDQYQTLDDFMADFHLMFDNAC 695
                          90       100
                  ....*....|....*....|....*.
Feature 1           #     #                 
2YQD_A         95 TYNEPESLIYKDALVLHKVLLETRRD 120
gi 24370475   760 RYNEPESMIYKDALSLQKLILLKRRD 785
gi 7301208    721 KYNEPDSQIYKDALVLQQLTLQLKQQ 746
gi 110765845  743 KYNEPDSQIYKDALILQRLVLQTKLQ 768
gi 108884551  710 KYNEPDSQIYKDALCLQQLIIQTKQS 735
gi 18958139   790 KFNETDSDIYKEAVSLQKALLEMKRE 815
gi 54648598   760 TYNEPESLIYKDALVLHKVLLETRRD 785
gi 68534308   150 TYNEPESLIYRDALLLHRAFLEARRR 175
gi 115668674  785 KFNEPDSLIYKDALTLQRILLQTKTE 810
gi 156363502  696 KYNEPDSQVYKDSLTLLRSLLRKKAE 721

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