Conserved Protein Domain Family
Bromo_polybromo_II

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cd05517: Bromo_polybromo_II 
Bromodomain, polybromo repeat II. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. It was shown that polybromo bromodomains bind to histone H3 at specific acetyl-lysine positions. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine, but not all the bromodomains in polybromo may bind to acetyl-lysine.
Statistics
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PSSM-Id: 99948
View PSSM: cd05517
Aligned: 10 rows
Threshold Bit Score: 144.889
Threshold Setting Gi: 149034194
Created: 13-Sep-2006
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
putative
Feature 1:putative acetyllysine binding site [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                         #    #  #                                       
gi 50417257   184 LKAILEQLLEAIAsctds--sgrlvSELFQKLPsklhYPDYYAVIKEPIDLRAVAQKIQgg-hYKSISAMAKDIDLLVKN 260
gi 951231     179 LKEILEQLLEAVAvatnp--sgrliSELFQKLPskvqYPDYYAIIKEPIDLKTIAQRIQng-tYKSIHAMAKDIDLLAKN 255
gi 30721853   182 LKEILEQLLEAIVvatnp--sgrliSELFQKLPskvqYPDYYAIIKEPIDLKTIAQRIQng-sYKSIHAMAKDIDLLAKN 258
gi 54648598   234 LKPSLEQLLESITtathp--ggrmiSELFQKLPskvhYPDYYAIIKDPIDLKTIAQRIQsg-hYKSVNAMAKDIDLLTKN 310
gi 7301208    191 EYNQYEELFASVMtatdpv-gdrlmHRMFQLLPskkiYPDYYDVIEHPIDLRLIATKIQmn-aYSSLAEMERDLLQMTKN 268
gi 110765845  218 TMQQFEDLFAAIMtatdpadnnrplHTMFQLKPskklYPEYYDVIETPVDLKTVARKIQeg-vYNSITDMEKDLMLMCRN 296
gi 156363502  143 SQQFYEEMVGAVLemqds--hgriiCELFKRLPpkdlYPEYYAVIKEPIDLKMISTRVRss-yYSTIEDLEKDLQVMVKN 219
gi 149034194  182 LKEILEQLLEAIVvatnp--sgrliSELFQKLPskvqYPDYYAIIKEPIDLKTIAQRIQdansIKKIFYMKKAEIEHHEM 259
gi 156349330   86 SQQFYEEMVGAVLemqds--hgriiCELFKRLPpkdlYPEYYAVIKEPIDLKMISTRVRss-yYSTIEDWKRIFRYIEGL 162
gi 115668674  200 PNDPGEILFTAVMghrdv--tgrivSLMFRKLPrqqeFPAYYEIIDNPIDLCDIAIKIKnk-kYDRLSDLDKDLCLMVKN 276
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
Feature 1         #   #                     #               
gi 50417257   261 AKTYNEPGS----------------QVFKDANTIKKVFAQRK 286
gi 951231     256 AKTYNEPGS----------------QVFKDANAIKKIFNMKK 281
gi 30721853   259 AKTYNEPGS----------------QVFKDANSIKKIFYMKK 284
gi 54648598   311 AKTYNEPGS----------------QVFKDANTIKKLFALKK 336
gi 7301208    269 ACLFNEPGS----------------QIYKDAKSLKRIFTQRR 294
gi 110765845  297 ACQFNEPGS----------------QIYKDAKLLKKIITAAA 322
gi 156363502  220 AHTFNEPGS----------------QVYKDASAIKKTIQAKK 245
gi 149034194  260 TKSSLRISNkravqggrlsaitmalQYGSESEEDAALAAARY 301
gi 156349330  163 RDGNPHMSNw--------------tQSRKPDAATMTPQQLAQ 190
gi 115668674  277 AKQFNEPGS----------------QIYKDAVTLKKVMTAKK 302

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