Conserved Protein Domain Family
Bromo_polybromo_IV

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cd05518: Bromo_polybromo_IV 
Bromodomain, polybromo repeat IV. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. It was shown that polybromo bromodomains bind to histone H3 at specific acetyl-lysine positions. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine, but not all the bromodomains in polybromo may bind to acetyl-lysine.
Statistics
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PSSM-Id: 99949
View PSSM: cd05518
Aligned: 9 rows
Threshold Bit Score: 186.882
Threshold Setting Gi: 156363502
Created: 13-Sep-2006
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
putative
Feature 1:putative acetyllysine binding site [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                        #    #  #                                      # 
gi 30721853   519 RKQRMKILFNVVLEarepgsGRRLCDLFMVKPSKKDYPDYYKIILEPMDLKIIEHNIRNDKYAGEEGMIEDMKLMFRNAR 598
gi 47229755   588 KKNRMKALFAAVTEareagtSRRLCDLFMVKPSKKDYPDYYKVILEPMDLRTIEQNIRNERYNTEEALMDDMKLMFRNAR 667
gi 951231     517 RKQRMKILYNAVLEaresgtGRRLCDLFMVKPSKKDYPDYYKIILEPMDLKMIEHNIRNDKYVGEEAMIDDMKLMFRNAR 596
gi 54648598   542 RKQRMKILFNTVLEarepatGRRLCELFMFKPSKKDYPDYYKIILEPMDLKTMEQNIRSEKYATEETMMNDMKLMFRNAM 621
gi 7301208    512 IKKKILSIQKYLVDys--lgNRRPIEMFMEKPPRKIYPDYYDIIQNPIDMNTIEHNIRTDRYAAVEDVVSDYRLMFSNCR 589
gi 110765845  529 LKKRLYALVKCVIEyv--vnGRQPMLMFMEKPSKKLYPDYYQVIAEPIDMLAIEANIKAEKYQNENELIQDFKLMFNNCR 606
gi 108884551  503 LRKKLLSLHEYMLQyt--vnGRQPMGLFIEKPSKKLYPDYYQVIQHPIDMTTIENNIKSDRYGVLDDAVGDYRLMFSNCR 580
gi 156363502  482 SHPLYLFINLYLFTpqd-gsGRQLCIIFQKLPSRAEYPDYYKVISEPVCLSQIEGNIRDNKYATEEELLLDFEVMFDNAR 560
gi 115668674  576 QKSKLMALYLSLVHyke-esGRSPITLFMEKPSKKEYPDYYHIITEPIDMKTIETNIKNEKYQTEEGVMKDFSLMFDNAR 654
                          90       100
                  ....*....|....*....|....
Feature 1           #     #               
gi 30721853   599 HYNEEGSQVYNDAHILEKLLKEKR 622
gi 47229755   668 HYNEEGSQVYNDADILEKILKDKR 691
gi 951231     597 HYNEEGSQVYNDAHMLEKILKEKR 620
gi 54648598   622 HYNEEGSQVYNDAHVLEKFLKDKK 645
gi 7301208    590 QYNEEGSNIYEDANILERALNEKL 613
gi 110765845  607 QYNEEGSLIYEDANTLERVLMDKV 630
gi 108884551  581 KYNEEGSMIYEDANILEKALNEKL 604
gi 156363502  561 YYNEEESQVYQDACLLEKVLRKKK 584
gi 115668674  655 HYNEEGSMVYEDANLLEALLKDKF 678

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