Conserved Protein Domain Family
Bromo_SNF2

?
cd05519: Bromo_SNF2 
Bromodomain, SNF2-like subfamily, specific to fungi. SNF2 is a yeast protein involved in transcriptional activation, it is the catalytic component of the SWI/SNF ATP-dependent chromatin remodeling complex. The protein is essential for the regulation of gene expression (both positive and negative) of a large number of genes. The SWI/SNF complex changes chromatin structure by altering DNA-histone contacts within the nucleosome, which results in a re-positioning of the nucleosome and facilitates or represses the binding of gene-specific transcription factors. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.
Statistics
?
PSSM-Id: 99950
View PSSM: cd05519
Aligned: 10 rows
Threshold Bit Score: 180.999
Threshold Setting Gi: 34559250
Created: 14-Sep-2006
Updated: 17-Jan-2013
Structure
?
Aligned Rows:
 
putative
Feature 1:putative acetyllysine binding site [chemical binding site]
Evidence:

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Feature 1                                     #    #  #                                      # 
AAS53933  1303 IAAQSKELYDYILsyr-neeGRNLAEIFLVKPSKKLYPDYYLLIRYPAAFEDVTRHIEAkaYDSIKEVVEDFHLIFANAR 1381 Ashbya gossypii ...
XP_461680 1413 LQGNMITIYDSIInha-ddqGRILSDLFLQKPSKKLYPDYYVLIKHPIALDIIKKRIQGrsYTNIREILEDFHLMFSNAR 1491 Debaryomyces han...
AAQ75381  1316 LQLQLNEILDRLLtms--idGRKLSTIFLTKPIKRVYPDYYVIIKNPIAFDGIKRRVQGevYWSLEEFIYDLHLMFANAR 1393 Pichia angusta
BAD11105  1066 LRRVCLEIYKAVNele-ddnGRPLNKLFLELPSKKLYPDYYMIIKSPIALDAIRKHINGtfYKTLEAMKSDLMTMFNNAR 1144 fission yeast
XP_503184 1377 LLGIMKTLYNHVLnve-dstGRARINLFLELPSKTDYPDYYILIKQPISCAQISKRIQSsyYQSLDQFLEEFALMFANAK 1455 Yarrowia lipolyt...
134589    1550 VAKQALDLYHFALnye-neaGRKLSDIFLSKPSKALYPDYYMIIKYPVAFDNINTHIETlaYNSLKETLQDFHLIFSNAR 1628 baker's yeast
BAD11104  1518 LRRYCMEIFERLYnlq-sedGRFVNGLFLYPPNRKLYPDYYIIIKRPIALGKIKRNIKNdrYGDVGELIADFMLMFNNAY 1596 fission yeast
XP_757330 1509 IKYALNQCYRAVEtclepetGRKRCLLFLDVPKKTDYPDYHVIIEKPIAMRQIKRRIDNrtFRRVDTCRDEFHLMVRNAK 1588 Ustilago maydis 521
EAU93321  1300 MKKAFQECFKAVTnce-aeaGRKRCELFRELPDRRDYPDYYQLISQPISLAQIRKRYTGthYKSVQQFKNDFLLMFNNAR 1378 Coprinopsis cine...
EDP43845   343 LKAAMLKCYHAVEqceepdtGRLRSTLFMEIPKKNEYPDYHVLIARPVCLKQIKRRIETrvYKTFEACRDDFLLMFHNAR 422  Malassezia globo...
Feature 1        #     #               
AAS53933  1382 VYNTEGSTIYNDSIELEDAVVQKY 1405 Ashbya gossypii ATCC 10895
XP_461680 1492 IYNEEGSIVYQDAVALEDLVVEKF 1515 Debaryomyces hansenii CBS767
AAQ75381  1394 IYNQEGSMVYNDSQLMEDEALKMY 1417 Pichia angusta
BAD11105  1145 TYNEEGSFVYEDANKMQTAMETKI 1168 fission yeast
XP_503184 1456 QYNEEGSFVYEDAVALHNALLDKA 1479 Yarrowia lipolytica CLIB122
134589    1629 IYNTEGSVVYEDSLELEKVVTKKY 1652 baker's yeast
BAD11104  1597 TYNEEHSIVYEDAKLMEKTLKEVI 1620 fission yeast
XP_757330 1589 TYNQEGSWVYNDAVELQKAFDTTY 1612 Ustilago maydis 521
EAU93321  1379 TYNQEGSWVYVDADEMEKVFKKAF 1402 Coprinopsis cinerea okayama7#130
EDP43845   423 TYNQEGSIVWLDSLEMEHVFNDVY 446  Malassezia globosa CBS 7966

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap