Conserved Protein Domain Family
Bromo_polybromo_III

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cd05520: Bromo_polybromo_III 
Bromodomain, polybromo repeat III. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. It was shown that polybromo bromodomains bind to histone H3 at specific acetyl-lysine positions. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine, but not all the bromodomains in polybromo may bind to acetyl-lysine.
Statistics
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PSSM-Id: 99951
View PSSM: cd05520
Aligned: 10 rows
Threshold Bit Score: 155.575
Threshold Setting Gi: 156363502
Created: 13-Sep-2006
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
putative
Feature 1:putative acetyllysine binding site [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                             #    #  #                                   
gi 30721853   382 VSNPFYQLYDTVRSCRNnq------gQLIAEPFYHLPSKKKYPDYYQQIKMPISLQQIRTKLKnqeYETLDHLECDLNLM 455
gi 951231     380 TSNPLYQLYDTVRSCRNnq------gQLISEPFFQLPSKKKYPDYYQQIKTPISLQQIRAKLKnheYETLDQLEADLNLM 453
gi 54648598   404 ISSPLYQLYETVRSCRNnr------gQLIAEPFFHLPSKKKYPDYYQQIKNPVSLQQIRSKLKnqeYDGLDQLESDLNLM 477
gi 110765845  383 ADNPQWQLFQTIRTAPNnq------gVRMSEYFWKLPSKRLYPDYYKTIKNPISLLQIRTKIKkgeYGTVSEVAGDMNIM 456
gi 24370475   320 SSEPKWILYWTIRNEPNpvd----peTNLADPFLELPSKSWYPDYFDEISDPMSLFMINKKLKrdeYHTLEELLKDIVLV 395
gi 18958139   340 NSEPMWKLYWTIRNAVHekd----rnVTLADNFLELPSKESYPDYYDEIKNPVSIFMINKRLKn-gKYDLKSLVADLMQM 414
gi 7301208    335 GEGPMWALFDHLYNAPGtsehpgvtgPPLGNSLWKLPVRRFHPEYFELIKRPISMSQIHTKLKkgdYANISDLTADLYLM 414
gi 156363502  341 AENPLMMLFNEIYQHTDpt------gRPMVEPFLRLPSRRAYPDYYEVIKKPIALMKIRSQIKsglYDSLEALETELELC 414
gi 47229755   419 TSNPIFQLYEAVRGARNnq------gQLFSEPFQQLPSRREYPDYYQQIKQPISLQQIRGKMKngeYESLEQIDADLSLM 492
gi 115668674  399 SPDPLHILFNFVLNFRNnl------gQLLSEPFMRLPNSRIYPDYYREIKKPIALTKIRSKLKnnkYKSLEELGTDLELM 472
                          90       100
                  ....*....|....*....|....*....
Feature 1            #   #     #               
gi 30721853   456 FENAKRYNVPNsAIYKRVLKLQQVMQAKK 484
gi 951231     454 FENAKRYNVPNsAIYKRVLKMQQVMQAKK 482
gi 54648598   478 FENAKRYNVPNsAIYKRVFKLQQLMQAKK 506
gi 110765845  457 FENAKKYNIHTsRLYKCAVKLQKIMQEKV 485
gi 24370475   396 FENAKTYNVEGsDIYEAAAKLERLARSKT 424
gi 18958139   415 YSNAFDYNLESsEVYISAEKLKALTISTC 443
gi 7301208    415 LDNAKKAFPTShRTHKDALKMLKLMNAKL 443
gi 156363502  415 FNNAKTYNEPNsMLYKDAERMLDHMSKKK 443
gi 47229755   493 FENAKRYNMPNsSIYKRAFRLQQIVQSKK 521
gi 115668674  473 FQNAYHYNMPTsQLHKDAEKLHKAMQHKR 501

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