Conserved Protein Domain Family
Bromo_Rsc1_2_I

?
cd05521: Bromo_Rsc1_2_I 
Bromodomain, repeat I in Rsc1/2_like subfamily, specific to fungi. Rsc1 and Rsc2 are components of the RSC complex (remodeling the structure of chromatin), are essential for transcriptional control, and have a specific domain architecture including two bromodomains. The RSC complex has also been linked to homologous recombination and nonhomologous end-joining repair of DNA double strand breaks. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.
Statistics
?
PSSM-Id: 99952
View PSSM: cd05521
Aligned: 12 rows
Threshold Bit Score: 155.173
Threshold Setting Gi: 149244482
Created: 13-Sep-2006
Updated: 17-Jan-2013
Structure
?
Aligned Rows:
 
putative
Feature 1:putative acetyllysine binding site [chemical binding site]
Evidence:

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                        #    #  #                                      #
gi 12230583   16 ALYKDLRKEYESLFTLKEDs-GLEISPIFNVLPPkkDYPDYYAVIKNPVSFNTLKKRIPh--YTDAQQFMNDVVQIPWNA 92
gi 50304341    6 PLKEVIKPLVNIIYELKEEn-GLEIHPIFHLLPPkrDYPDYYQIIEHPISLSTVRKRMTq--YKNPQEFVNDLARVTWNA 82
gi 50285331    6 ELQENLRPEYLRLYNVINEe-NVNISPVFTVLPPrkDYPDYYDVIKKPISINTLKKRLTt--YTNAQQFMDDLVHIPWNA 82
gi 45185225    2 LLRDQLKVLLDGVFDLKEEn-GIEILPIFYTLPLrkDYPDYYRIIKKPLSLATVKKKLNh--YKRAQEFVNDLVRITWNA 78
gi 1723670     8 FLQKLLKTQYDAVFHLKDEn-GIEIYPIFNVLPPkkEYPDYYIIIRNPISLNTLKKRLPh--YTSPQDFVNDFAQIPWNA 84
gi 68468809    8 KLSTKLQSLFNGIYKIEDN--GYLIHPTFQTLPLr-SGTDYYKVVQNPLSLHAVGRKLKnlkYADAQEFINDLALISWNA 84
gi 50418048    9 KLANKLQPLYDGIYSLKDSq-GREISETFQRLPLr-TGTDYYKVIKVPVSLHGVGRYIKkyvYRTAQEFVTQLVQITWNA 86
gi 50551221   25 PISDLISPLFDGIYTIDNDidNNKVFEVFHSLPDr-SLTTYYKVIKRPLSLTQIKRSMPr--YRNVQNFIHDLAQITYNA 101
gi 49527728    9 ELRTDLRKQYEAIFSLKEEs-GANIFPIFNVLPIkkDYPDYYAIIKNPISLNTLKKRLPh--YTSPQDYVNDVSQIPWNA 85
gi 156839301   8 LLYKRLKNEYDELFRVKEEn-NLEIHPIFNVLPSkkEYPDYYALVKNPISFNTLKKRLQg--YNDPQLFVNDVAFIPWNA 84
gi 150864525   9 KLNNRLQSLYDRVYKIEDH--GHPIATTFHTLPLr-TGTDYYKIVKNPLSLHGVGRKIKnskYDDGQQFVDDLSQVSWNA 85
gi 149244482   8 KLLSKLQPIFDSLYNVEEN--GIPIVTHFQTLPLr-TGTDYYKIIKKPLSLHAVGRSIKklkYSNAQEFINDLALISWNA 84
                         90       100
                 ....*....|....*....|....*....
Feature 1           #     #                   
gi 12230583   93 KTYNTRDSGIYKYALVLEKYLKDTIYPNL 121
gi 50304341   83 RTYNTKDSDVYHYAVILDKCVKDTIIPSL 111
gi 50285331   83 KVYNTKESEIYKYALTLEKFINETVYPNL 111
gi 45185225   79 RMYNTKESEIYHYAQIMDRYVREVVIPRI 107
gi 1723670    85 MTYNAKDSVIYKYAILLESFIKGKIVHNI 113
gi 68468809   85 RFYNHSKSVIYRQAQILKQYITDVVIPKL 113
gi 50418048   87 RLYNVRTSLIYDHALILNQYILDKIIPRL 115
gi 50551221  102 RLFNMKGSGIYNDAVFLDGYLNKAIAVLR 130
gi 49527728   86 KTYNSKGSLIYIYADILEKFLRNVSVPQL 114
gi 156839301  85 KLYNTPTSVIVKYANILENHIRNSLVPNL 113
gi 150864525  86 RLYNIRESKVYRHALILKQFVLTVVIPKL 114
gi 149244482  85 RYYNLPGSDVYRHAQLLTDFINDYAIVKL 113

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap