Conserved Protein Domain Family
Bromo_Rsc1_2_II

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cd05522: Bromo_Rsc1_2_II 
Bromodomain, repeat II in Rsc1/2_like subfamily, specific to fungi. Rsc1 and Rsc2 are components of the RSC complex (remodeling the structure of chromatin), are essential for transcriptional control, and have a specific domain architecture including two bromodomains. The RSC complex has also been linked to homologous recombination and nonhomologous end-joining repair of DNA double strand breaks. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.
Statistics
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PSSM-Id: 99953
View PSSM: cd05522
Aligned: 19 rows
Threshold Bit Score: 146.617
Threshold Setting Gi: 27803071
Created: 13-Sep-2006
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
putative
Feature 1:putative acetyllysine binding site [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                          #    #  #                                      
gi 27803071   334 PLEARTQSLLKGLRRFKSDdg--qLRILSFERLPDKADMPDYYASIRNPIALDTIKKKHKRKkYTTIDQVLQDLELMFGN 411
gi 50285331   262 PYVQRMKNVLKVIRKEVDErr--rSLLDSFEKIPDRNYNPQYYSIISNPISLDEIRKKVKTRkYKDFEGFHNDIKLMLSN 339
gi 12230583   276 PYIQRMKNVMKVLKKEVLDsg--iGLTDLFERLPDRHRDANYYIMIANPISLQDINKKVKTRrYKTFQEFQNDFNLMLTN 353
gi 50418048   244 PYETRIKLILKHFKKLRHPndpnhPLSIHFDRLPDPKTNSNYYQVIKQPISLNEIRTKVRTRkYHNVDEFISDLNLMFQN 323
gi 1723670    236 PYVLRIKNILKMMRREVDQnn--kTLTLCFEKLPDRNEEPTYYSVITDPICLMDIRKKVKSRkYRNFHTFEEDFQLMLTN 313
gi 68468809   228 PFETRIKLILKGFKKLRDNng--hPLTKHFEKLPDIKTHGDYYERIAAPISLNEIRIKVRSRkYSSVELFINDLDLMFAN 305
gi 45185225   233 PYEQRIKNVLKNLKRETLSgs-reFLTLHFDRLPDEEREPQYYTVISNPLSLDDIRKRVKQRkYKDFLAFQQDVGLMLNN 311
gi 156839301  318 PYVQRIKNIFKMLRKVVDQag--ePLTLTFEKLPSKESFPQYYQLIKNPISLEDIRKKVKTRkYKDFKTFHDEMNLMLSN 395
gi 156839446  253 PYVQRMKNVIKMLRRETDEsk--rQLTATFEKIPDEHEETKYLSIISNPMPLEEIFKKVKTRkYKDFQGFQNDMNLMVAN 330
gi 150864525  228 PFETRIKLILKSFKKLRDPnnesrSLTQHFDKLPDTKTNPSYYHTITNPISLFEIKVKVRTRkYTSVDQFIHDLDVMFSN 307
                          90       100
                  ....*....|....*....|....*...
Feature 1         #   #       #               
gi 27803071   412 AMQFNEEG--SQVHEDATELLKQARLLT 437
gi 50285331   340 YRTYNKNN--PNELKRSFKFEKSFNELA 365
gi 12230583   354 FRISHRGD--PESIKISNILEKTFTSLA 379
gi 50418048   324 TKFYFSNDqlSPTFQDCLLFESEANNVI 351
gi 1723670    314 FKLYYSQD--QSNIIRAQLLEKNFNRLV 339
gi 68468809   306 AQLYYENDpySEEFLDSQQFKKEAHLVI 333
gi 45185225   312 YRMYHRSQ--PQEMRRAAEFEAKFTDFA 337
gi 156839301  396 YKIANLNS--PHNLKRHALLEKDFNLMV 421
gi 156839446  331 YKLYYRSN--PQALKRANLLERRFAEYS 356
gi 150864525  308 FQMFYQNDpySEEFIDFQNFNREAHAII 335

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