Conserved Protein Domain Family
Bromo_polybromo_VI

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cd05526: Bromo_polybromo_VI 
Bromodomain, polybromo repeat VI. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. It was shown that polybromo bromodomains bind to histone H3 at specific acetyl-lysine positions. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine, but not all the bromodomains in polybromo may bind to acetyl-lysine.
Statistics
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PSSM-Id: 99956
View PSSM: cd05526
Aligned: 10 rows
Threshold Bit Score: 155.988
Threshold Setting Gi: 156363502
Created: 13-Sep-2006
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
putative
Feature 1:putative acetyllysine binding site [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                              #     #  #                                 
gi 68534308   193 ASLVRELIRNLFVSMMghqd----degrCYSDSLAEVP-----AIDPANPDDPPLTLEIIRNNVDSGr-YRRLDVFQEHV 262
gi 71980955   822 APRVQVELRTIFTSIFaslfskkdeegkCYSDHLTEFTev--lKANGVPSSEWPFTLDQIKMNIDKCr-YRRLDKLQKDF 898
gi 7301208    758 PLAVQELFLTLFTTIYnhqd----eegrCYSDSLAELPe---yDEIGEGPKVRGISLDLVKRRLDKGa-YKRLDVYQEDI 829
gi 951231     773 TLLIQELIHNLFVSVMshqd----degrCYSDSLAEIP-----AVDPNFPNKPPLTFDIIRKNVENNr-YRRLDLFQENM 842
gi 11385354   775 TLLIQELIHNLFVSVMshqd----degrCYSDSLAEIP-----AVDPNFPNKPPLTFDIIRKNVENNr-YRRLDLFQEHM 844
gi 54648598   798 TLLIQELIHNLFVSVMshqd----gegrCYSDSLAEIP-----AVDPKFPKRPPLTFDIIRKNVENNc-YRRLDLFQEHM 867
gi 110765845  780 SAAIQEILATIFTALYnhqd----eegrCYSDSMAELPe----HDIIDGKKIRGLSLDLIKRRLDRGv-YKRLDRFQEDV 850
gi 24370475   797 QSEVQALLASILISVNnhqd----sdgrCFSDSLADLPgm--lRRKGIDSVNIPFSIDEMKRSVDKGr-YRRLDKFQDDL 869
gi 156363502  733 SFLVQKLLMTLYSSVMqhvd----eegrCYSDSLAELTg---sDLVKLSKMDINFIIVFIVIFFTFQyqYHRLDKFQEDM 805
gi 115668674  823 QGLVREIITSLFVSVAnhqd----eegrCYSDSLAEIPvdkdaMMDDPNLQKKPLDLDTIRRYLDRGc-YRRLDCFQDHI 897
                          90       100       110
                  ....*....|....*....|....*....|....*...
Feature 1               #   #     #                     
gi 68534308   263 FEVLEKARRLNRTDsEIFEDSVELQHFFVKIRDELCKN 300
gi 71980955   899 FDLFERARELSKAGsSMYEAACTLQKSFIVERDTRCKD 936
gi 7301208    830 FACLERARKLSRTDsDIFQDSIELQTYFIRKRDELCKD 867
gi 951231     843 FEVLERARRMNRTDsEIYEDAVELQQFFIKIRDELCKN 880
gi 11385354   845 FEVLERARRMNRTDsEIYEDAVELQQFFIKIRDELCKN 882
gi 54648598   868 FEVLERARRLNRTDsEIYEDAVELQQFFIKIRDELCKN 905
gi 110765845  851 FTCLERARRLSRTDsQPFEDSVELQAFFLRTRDEVTRG 888
gi 24370475   870 FFLFNAAMDHAHSDsQVFEDTVELWMYYLKTRDDLTRT 907
gi 156363502  806 FSIFEKARKISHSDcEMYDDASELQVYFITQRDKLCKE 843
gi 115668674  898 FFVLERARQLSRTDsQVYEDSIEMQRFFIQIRDEICKN 935

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