Conserved Protein Domain Family
Bromo_WDR9_I_like

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cd05529: Bromo_WDR9_I_like 
Bromodomain; WDR9 repeat I_like subfamily. WDR9 is a human gene located in the Down Syndrome critical region-2 of chromosome 21. It encodes for a nuclear protein containing WD40 repeats and two bromodomains, which may function as a transcriptional regulator involved in chromatin remodeling and play a role in embryonic development. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.
Statistics
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PSSM-Id: 99958
View PSSM: cd05529
Aligned: 21 rows
Threshold Bit Score: 117.438
Threshold Setting Gi: 65304741
Created: 13-Sep-2006
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
putative
Feature 1:putative acetyllysine binding site [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                         
gi 97535778  1149 LYKPQAGEWGq---------------------kSRDEECDRIISGIDQLL--------------------NLDIAAAFAG 1187
gi 23172157  1196 LYQPKSEEWHr---------------------gDRDGTCRRIINGLEQVM--------------------RLSIAEHFLA 1234
gi 91094543   999 LYQPTADDWPn---------------------sDREAVTCYILTGLAKVM--------------------ELAIAEPFLV 1037
gi 67469875   806 VSSNGSIDVSineidsdy--------tehrsddFADEVREILINKLREIV--------------------DNEDYQIFKT 857
gi 66808613  1705 KDNILRIKIQyv-------------------esIEDEKIENLKKEMKEFLe-------------------NDEITDIYSE 1746
gi 89292843  1712 LEGPNMIRIScwdviypirrtsspddypnddacLSKEETEQIFKLIQAVId------------------nQSEITCYFEE 1773
gi 145503918 1263 HKSNKSIEIQ-----------------------GASLQSALTTNEAQQINrdina-----------mikkQTKIAFFFSN 1308
gi 116000631  584 LYNDELMRKEhakllsgast---srgpqktpfsNVDESSPSLTPGVTKELlsr---------------vlRLARNDRFEA 645
gi 32398813  1457 IYETVPDKKSl---------------------pNNLEASNDLIKIFCWMTtqng-------------qnnPLSVVEFFKY 1502
gi 65304741  1526 ISYDKKIKWVd---------------------cWNLDLNDEIKPKLEEVFgkikskglnqehkdkflnliQDPKYGIFEY 1584
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1          #                  #  #                                       #   #     #      
gi 97535778  1188 PVDLc--------------tYPKYCTVVAYPTDLYTIRMRLVNR-FYRRLSALVWEVRYIEHNARTFNEPeSVIARSAKK 1252
gi 23172157  1235 PVDLn--------------iYPDYAYLIEYPIDLTTIKSRFENH-FYRRITSAQFDVRYLATNAEQYNRRhAIIVKHSRI 1299
gi 91094543  1038 PVDLn--------------tYPTYAVIVEYPVDLSTIKARFENR-FYRRLTAAQFDVRHLAANAEKFNERhSIIVKHARI 1102
gi 67469875   858 PVDIr--------------mYPNYIPTCPFPIDFNLILQRLINDnYYRTYDQVEWEIFKLIRNAVTYNGPnSPIGECAIE 923
gi 66808613  1747 PVDLk--------------lYPLYIRFVPHPMDISTIIKRLESS-YYRSLDAIYFDAKLIMIDAYVYNKPnTMVAKNSKL 1811
gi 89292843  1774 AVNLk--------------kYKHYYEFVEFPMDISKIRRRLLNG-YYRSQQSIFHDINLIDSNAHKFNNPdSPICESSKR 1838
gi 145503918 1309 EVDVq--------------qYPEYLDYVPLMSYITLIQRRLEND-FYRSKDQILNDVERIRRNAYIFNPPkSEVCDLADK 1373
gi 116000631  646 FVNVigpnekf---tradgtVTNYCSLVPVPMALNLIINRLKNS-YYRQIDGFRSDVELIRVNAEIFHGEgSVFANFAAE 721
gi 32398813  1503 PIPFfskkniskngfsnqewVMHYWKEIPLPFSFTSIINRIRNN-YYRRLESLVFDIFLVRSNCEHFNINnNNLVQGIRS 1581
gi 65304741  1585 VEEYglrs---------hewVYEYWRYIPRPISLNEIREKLRND-YYRTPKGVWAEIKLLISNCINFNETsSNYSKIARE 1654
                         170
                  ....*....|..
Feature 1                     
gi 97535778  1253 ITDQLLKFIKNQ 1264
gi 23172157  1300 VTDLCLRIIREP 1311
gi 91094543  1103 LTELCLRIIKQC 1114
gi 67469875   924 IAEELKPTLETC 935
gi 66808613  1812 VFHRISDILKEA 1823
gi 89292843  1839 VKEILTSIVSNF 1850
gi 145503918 1374 LANLLHSIVNGD 1385
gi 116000631  722 LEDDLLDDLPST 733
gi 32398813  1582 IEYELLRLIFSK 1593
gi 65304741  1655 VDVNLDNLMINM 1666

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