1IIB,1E2B,1H9C


Conserved Protein Domain Family
PTS_IIB_chitobiose_lichenan

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cd05564: PTS_IIB_chitobiose_lichenan 
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PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N,N-diacetylchitobiose-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane channel IIC domain. In the chitobiose system, these subunits are expressed as separate proteins from chbA, chbB, and chbC of the chb operon (formerly the cel (cellulose) operon). In the lichenan system, these subunits are expressed from licA, licB, and licC of the lic operon. The lic operon of Bacillus subtilis is required for the transport and degradation of oligomeric beta-glucosides, which are produced by extracellular enzymes on substrates such as lichenan or barley glucan. The lic operon is transcribed from a gammaA-dependent promoter and is inducible by lichenan, lichenan hydrolysate, and cellobiose. The IIB domain fold includes a central four-stranded parallel open twisted beta-sheet flanked by alpha-helices on both sides. The seven major PTS systems with this IIB fold include chitobiose/lichenan, ascorbate, lactose, galactitol, mannitol, fructose, and a sensory system with similarity to the bacterial bgl system.
Statistics
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PSSM-Id: 99906
View PSSM: cd05564
Aligned: 73 rows
Threshold Bit Score: 101.041
Threshold Setting Gi: 159874732
Created: 2-May-2007
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 7 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1             # ## ##                                            #                       
1IIB_A         5 HIYLFSSAGMSTSLLVSKMRAQAEKYEVpVIIEAFPEtlag--ekgQNADVVLLGPQIAYmlpei--qrllpNKPVEVID 80  Escherichia coli
NP_470254      3 NILLICGSGASSGFMAAAIRKAAKKRGEkVTVKAASEsqid--eriNEIDYLLIGPHLAYmlddlkqkvadkDVLVSVIP 80  Listeria innocu...
YP_074780      2 FILLACGMGASSGFLAQSMRKAAKSRGIeATIKAVSDtqid--dylNDIDVLLIGPHLKHrfrdieskaapyQVKVVLVD 79  Symbiobacterium...
YP_804108      4 NVLLVCGSGASSGFMAANMRKAAKKVGLdYKIQARSEaeln--dyaNDIDVLMVGPHLKSefnalk-navpeNVTPILME 80  Pediococcus pen...
YP_818418      5 NILLICNTGASSSFMAQKIRQASNENQQaCQVHAASMtqid--eyiDRIDYLLISPQLKYaeseirlsvansNIKVAVIP 82  Leuconostoc mes...
YP_001089596   5 RVLLACGSGASTGFMATSMRKSAKKKGIeADIKARSEseid--kylSEIDCLLLGPHLDYmkeeiqqkaneyNVPVACIS 82  Clostridium dif...
YP_001309775   2 KVLMVCSGGMSSAIVVQAIKKEADKEGFdLEIKAVGTsdfedeiqqNKYDLVLVAPQVRHrlngfkdqakeySLEVIAIE 81  Clostridium bei...
EDP10984      23 KVLLACGSGASSGFMASNMRKAAAENNVdADIHAVSDseip--eyiDKVDVIMLGPHVKYleeelkkkaavyGVPVACIS 100 Eubacterium dol...
EDP11582       3 HVLLICSQGASTAIMCDKIRQEAQKDGVeMEIKAVPLatss--dyiSQADIILLGPQIRYmkkkv--qaeagNTLVMDID 78  Eubacterium dol...
EDP67080       2 KVIMVCSGGMSSAIVVKAIKAEAAKQDFdLDMIAVGSgavedalkeEDYKLLLVAPQVKHqfatfekyanenGVPIEKIE 81  Carnobacterium ...
Feature 1           #              
1IIB_A        81 SLLYGKVDGLGVLKAAVA 98  Escherichia coli
NP_470254     81 QATYGTLNGEKALDLILN 98  Listeria innocua Clip11262
YP_074780     80 ERSYAMLDGESVLNQILG 97  Symbiobacterium thermophilum IAM 14863
YP_804108     81 PDYYAILDGAAAIKHIQS 98  Pediococcus pentosaceus ATCC 25745
YP_818418     83 SKVYGLLDGNAVLNQIQK 100 Leuconostoc mesenteroides subsp. mesenteroides ATCC 8293
YP_001089596  83 KTAYGRLDGAKALEEALE 100 Clostridium difficile 630
YP_001309775  82 PMGYTPLGGARVLKQIKI 99  Clostridium beijerinckii NCIMB 8052
EDP10984     101 QQAYGILDGKRALSETIK 118 Eubacterium dolichum DSM 3991
EDP11582      79 MQAYGMMDGAKVYKSIKE 96  Eubacterium dolichum DSM 3991
EDP67080      82 PMGYTPIGAPKTLELIKK 99  Carnobacterium sp. AT7

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