Conserved Protein Domain Family
LbH_G1P_TT_C_like

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cd05636: LbH_G1P_TT_C_like 
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Putative glucose-1-phosphate thymidylyltransferase, C-terminal Left-handed parallel beta-Helix (LbH) domain: Proteins in this family show simlarity to glucose-1-phosphate adenylyltransferases in that they contain N-terminal catalytic domains that resemble a dinucleotide-binding Rossmann fold and C-terminal LbH fold domains. Members in this family are predicted to be glucose-1-phosphate thymidylyltransferases, which are involved in the dTDP-L-rhamnose biosynthetic pathway. Glucose-1-phosphate thymidylyltransferase catalyzes the synthesis of deoxy-thymidine di-phosphate (dTDP)-L-rhamnose, an important component of the cell wall of many microorganisms. The C-terminal LbH domain contains multiple turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes showing acyltransferase activity.
Statistics
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PSSM-Id: 100060
View PSSM: cd05636
Aligned: 25 rows
Threshold Bit Score: 210.907
Threshold Setting Gi: 34498558
Created: 8-Nov-2007
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2GGO_A       228 FSQNLG---NVEDNVKIKGKVIIEEDAEIKSGTYIEGPVYIGkgSEIGPnSYLRPyTILVEkNKIGASVEVKESVIMEgS 304
gi 118431361 240 SGGVEGevhSSAVLEGDVERIYIARGARIGAHSVVEGPAYIGpgARVGPgAHVRGyTVLLEgAYVGFASEVKASVIMEgA 319
gi 46447631   42 LGVLLGs-iSPQAYLIRPEEITIGEGSIVEPGAYIQGPCWIGnhCVIRHgAYIRGyVITGDyCVIGHDTEVKNSLFLNrA 120
gi 153889853  92 AHAVKE---AVSAAVRIEGTVWIDPSVKLPAYATIIGPAWIGagTEIRPgAFVRGnVITGEgCVLGNACEFKNCLLLDgV 168
gi 158439065  39 FIESLGaslPENEYKKIGKNIWIHKTAQMAPTTAMGGPMIIGpkVQIRNgAFLRGgVILGQhVVIGNSCEIKNSIIFDeA 118
gi 156937666 243 KMEFEV---REGLENPWGPGKVYGELPEVKGEVYVEGPVYFGegVVLGPfAHVRPyVALLDgVKVGPFVQVKESMIMEgS 319
gi 51246775   90 GRILEGaslIMAGASLIGDQISLGKGVLVETGAMIKSPTIIGdyCEIRQgAYLRGyCLAGAgCVLGHSTEIKHSIMLDgA 169
gi 156867497  38 FILALGpslPKDEYEEIKENVWAAKSAVIFPTAYLNGPVIIGknTEVRHgAFIRGsALVGDsAVVGNSTELKNVILFNnV 117
gi 154497326  60 LILSLGsqlSPEEYSQPREHVWVHKTAVVAPTAYLGAPCIIGpeTEIRHcAFIRGsALVGAhCVVGNSAELKNSILFDeV 139
gi 104783787  34 VMALLG---RLPPGYRRQGDCAVHETATVETGAVLKGPIIIGagCFVAAgAYLRGgVYLGRqCIVGPSCEVKSSFMLDgS 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2GGO_A       305 KIPHLSYVGDSVIAEdVNFGAGTLIANLRFDEKEvkvnvk--------gkrisSGRRKLGAFIGGHVRTGINVTILPGVK 376
gi 118431361 320 RAPHLNYVGDSVVGEhVNLGAGTVTANLRFDGRSvrmtvk--------gervdTGLRKLGAVIGGYAQTGINVSIMPGVR 391
gi 46447631  121 HAAHFAYVGDTILGHdVNLGAGTKCANFKLDQQTvsvvyk--------hqhfdTQLRKFGAIIGDRSQIGCNTVTNPGSL 192
gi 153889853 169 QVPHFSYVGDSILGNkAHLGAGVICSNLRLDQKAitvrlpattegtanggvvnTGLRKFGALLGDGAEAGCNSVLNPGSI 248
gi 158439065 119 QVPHFNYVGDSILGYkAHMGAGAVTSNVKADKGLvkvhae--------dgdveTGRKKFGAILGDHAEIGCNSVLNPGTV 190
gi 156937666 320 RLPHLNYVGDSVVAEdVNFGAGSVTANLRFDEREvevtlk--------gqrvsTGRRKLGAIVGGGARIGVNVSLMPGTR 391
gi 51246775  170 KAGHFNYLGDSILGNnTNLGAGTKLANLRFLPGNvhilhd--------kkqidSGLRKFGAIMGDDSQTGCNSVTSPGTV 241
gi 156867497 118 QVPHYNYVGDSILGYrSHMGAGSITSNVKSDKTLvtvkyq--------gekitTGLKKFGAILGDCVEVGCNSVLNPGSV 189
gi 154497326 140 QTPHYNYVGDSILGYkSHMGAGSVTSNIKSDKTSvvika---------etdifTGRRKVGAVLGDFVEVGCNSVLNPGTI 210
gi 104783787 111 KLAHFNFVGDSLIGAnVNVEAGAIIANYRNELDGapirirh------gdkvieTAVSKFGALIGDGCKIGANAVIAPGAL 184
                        170
                 ....*....|....
2GGO_A       377 IGAyARIYPGAVVN 390
gi 118431361 392 IGPrALVYPGCVVG 405
gi 46447631  193 IGMdVRAYPCLNIG 206
gi 153889853 249 LGRrALVMPTVAFA 262
gi 158439065 191 IGRnSNVYPLSSVR 204
gi 156937666 392 VGArSWIYPGCVVR 405
gi 51246775  242 LGKkCMLMPNTTTK 255
gi 156867497 190 ICPnSNIYPLSMVR 203
gi 154497326 211 LGRhSIVYPTSCVR 224
gi 104783787 185 LLPgTQVPRLGLID 198
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