2DF3,1URL


Conserved Protein Domain Family
Ig_Siglec_N

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cd05712: Ig_Siglec_N 
Click on image for an interactive view with Cn3D
Immunoglobulin (Ig) domain at the N terminus of Siglec (sialic acid-binding Ig-like lectins)
Ig_Siglec_N: immunoglobulin (Ig) domain at the N terminus of Siglec (sialic acid-binding Ig-like lectins). Siglec refers to a structurally related protein family that specifically recognizes sialic acid in oligosaccharide chains of glycoproteins and glycolipids. Siglecs are type I transmembrane proteins, organized as an extracellular module composed of Ig-like domains (an N-terminal variable set of Ig-like carbohydrate recognition domains, and 1 to 16 constant Ig-like domains), followed by transmembrane and short cytoplasmic domains. Human siglecs are classified into two subgroups, one subgroup is comprised of sialoadhesin (Siglec-1), CD22 (Siglec-2), and MAG, the other subgroup is comprised of CD33-related Siglecs which include CD33 (Siglec-3) and human Siglecs 5-11.
Statistics
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PSSM-Id: 143189
View PSSM: cd05712
Aligned: 7 rows
Threshold Bit Score: 172.215
Threshold Setting Gi: 56554238
Created: 17-Sep-2007
Updated: 18-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
 
ligand binding
Conserved site includes 3 residues -Click on image for an interactive view with Cn3D
Feature 1:ligand binding site [chemical binding site]
Evidence:
  • Structure:2DF3_A; human siglec-7 bound with DSLc4, a sialoside; contacts based on 3.5 A distance.
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
2DF3_A         3 YSLTMQssVTVQEGMCVHVRCSFsypv---tdsdPVHGYWFRASwk----aPVATNNPawaVQEETRDRFHLLGdpqtkn 75
1URL_A         2 WGVSSPknVQGLSGSCLLIPCIFsypad-vpvsnGITAIWYYDYsgk--rqVVIHSGDpklVDKRFRGRAELMGnmdhkv 78
gi 148235562  18 FKIEAPvnVIVQRGLCVLIPCNFtvgpk-ynltkDAIGIWYKGHpn----dPVAASTNssqFPDTTNGRFIFTGkvsagd 92
gi 54606385   22 WNVWMPrdISAMTNSCVVIPCSFtypsg-irpyrGVHGIWYFGHpypqlfpPVVLKSRtdiVHESYKGRTKLLGdltqkn 100
gi 20988662   21 YELQVQksVTVQEGLCVLVPCSFsypwrswysspPLYVYWFRDGeipyyaeVVATNNPdrrVKPETQGRFRLLGdvqkkn 100
gi 119572972  22 YSLQVQrqVPVPEGLCVIVSCNLsyprdgwdestAAYGYWFKGRtspktgaPVATNNQsreVEMSTRDRFQLTGdpgkgs 101
gi 113912104  22 WGAWMPssISAFEGTCVSIPCRFsfpde--lrpaVVHGVWYFNSpypknypPVVFKSRtqvVHESFQGRSRLLGdlglrn 99
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
Feature 1                          #        ##           
2DF3_A        76 CTLSIRDarmsDAGRYFFRMEkgn-ikWNYKYDQLSVNVT 114
1URL_A        79 CNLLLKDlkpeDSGTYNFRFEisdsnrWLDVKGTTVTVTT 118
gi 148235562  93 CSFSISDaqpgDAAKYRFRLEdrdplkFNYLHIQPSVSVT 132
gi 54606385  101 CTLLISNigveHSGKYYFRADlgganiYTFPDFTKLQVLD 140
gi 20988662  101 CSLSIGDarmeDTGSYFFRVErgrdvkYSYQQNKLNLEVT 140
gi 119572972 102 CSLVIRDaqreDEAWYFFRVErgsrvrHSFLSNAFFLKVT 141
gi 113912104 100 CTLLLSNlspeLGGKYYFRGDlggynqYTFSEHSVLDIIN 139

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