1PKO,1PKQ


Conserved Protein Domain Family
Ig_MOG_like

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cd05713: Ig_MOG_like 
Click on image for an interactive view with Cn3D
Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG)
Ig_MOG_like: immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG). MOG, a minor component of the myelin sheath, is an important CNS-specific autoantigen, linked to the pathogenesis of multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE). It is a transmembrane protein having an extracellular Ig domain. MOG is expressed in the CNS on the outermost lamellae of the myelin sheath, and on the surface of oligodendrocytes, and may participate in the completion, compaction, and/or maintenance of myelin. This group also includes butyrophilin (BTN). BTN is the most abundant protein in bovine milk-fat globule membrane (MFGM).
Statistics
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PSSM-Id: 319291
View PSSM: cd05713
Aligned: 37 rows
Threshold Bit Score: 151.577
Threshold Setting Gi: 149581818
Created: 31-Aug-2007
Updated: 18-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
 
Fab binding
Conserved site includes 11 residues -Click on image for an interactive view with Cn3D
Feature 1:Fab binding site [polypeptide binding site]
Evidence:
  • Structure:1PKQ_E; Rat MOG extracellular domain interacts with antigen binding fragment (Fab) of mouse monoclonal antibody,8-18C5; contacts based on 3.5 A distance.
    View structure with Cn3D
  • Comment:In rat MOG, a strained ligand-binding loop forms the upper edge of the binding site. It has been reported that the sequence of this loop, RDHSYQEE, appears unique for MOG.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                        ##                  #          #                                
1PKO_A        21 GDEAELPCRISPgknATGXEVGWYrspfsrvVHLYRNGKDQdaeQAPEYRGRTELLKESIgeGKVALRIQNVRFSDEGGY 100
1PKQ_E        21 GDEAELPCRISPgknATGMEVGWYrspfsrvVHLYRNGKDQdaeQAPEYRGRTELLKESIgeGKVALRIQNVRFSDEGGY 100
gi 59799178   45 GEDADLPCHLFPtmsAETMELRWVssslrqvVNVYADGKEVedrQSAPYRGRTSILRDGItaGKAALRIHNVTASDSGKY 124
gi 73921188   45 GTEATLPCQLSPeqsAARMHIRWYraqptpaVLVFHNGQEQgevQMPEYRGRTQMVRQAIdtGSVALQIQQVQASDDGLY 124
gi 119590289   3 GGHVELQCQLFPnisAEDMELRWYrcqpslaVHMHERGMDMdgeQKWQYRGRTTFMSDHVarGKAMVRSHRVTTFDNRTY 82
gi 126309742  64 GTDIILPCRLSPlmsAEHMEVRWFrsqfseaVFVFQKGKEEteeQLVEYTGRTELISEFIteGRLAVKIYNVQISDNGKY 143
gi 147225127  45 GGDAVLSCRVFPamnAEDMELRWFrskfseaVFIYQNRQEQkeeQLAGYAGRASLVRDFLsqGEAAVRIGQVQVSDNGLY 124
gi 147225175  43 GGDTVLPCSVSPamnLETMELWWFrskpsepVYVYRDGVEQpgeQMVDFKGRAELLKDYIneGKVAVRIHNLRVSDNGMY 122
gi 149052746  47 GQDKELPCKLSPnisAEGMELRWYrdkpssaVHVYKNGKDVydeQMTEYKGRTTFNGNRVarGEAAVKIHNVTMFDNGTY 126
gi 149578119 139 GDDVELPCHLEPkmnAQNMEVRWLrsqlfpaVHVYRDGQDQageQMGEYRGRTELLKDAIndGSLTVKIRDVRVSDDGEY 218
                         90       100
                 ....*....|....*....|.
Feature 1            # #### ##        
1PKO_A       101 TCFFR-DHSYqEEAAVELKVE 120
1PKQ_E       101 TCFFR-DHSYqEEAAVELKVE 120
gi 59799178  125 LCYFQ-DGDFyEKALVELKVA 144
gi 73921188  125 HCQFT-DGFTsQEVSMELRVI 144
gi 119590289  83 CCRFK-DGVKfGEATVQVQVA 102
gi 126309742 144 QCYFRkGDVY-EQASLEVKVA 163
gi 147225127 125 TCFFRkGVFY-EEASLELKVA 144
gi 147225175 123 KCFFKkGSYY-EEASLELKVI 142
gi 149052746 127 HCVFKeHTSY-DQATLWLKVA 146
gi 149578119 219 RCLFR-DDEKrDEATLQLQVT 238

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