Conserved Protein Domain Family
Ig_CSPGs_LP

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cd05714: Ig_CSPGs_LP 
Immunoglobulin (Ig)-like domain of chondroitin sulfate proteoglycans (CSPGs), human cartilage link protein (LP), and similar proteins
Ig_CSPGs_LP: immunoglobulin (Ig)-like domain similar to that found in chondroitin sulfate proteoglycans (CSPGs) and human cartilage link protein (LP). Included in this group are the CSPGs aggrecan, versican, and neurocan. In CSPGs, this Ig-like domain is followed by hyaluronan (HA)-binding tandem repeats, and a C-terminal region with epidermal growth factor-like, lectin-like, and complement regulatory protein-like domains. Separating these N- and C-terminal regions is a nonhomologous glycosaminoglycan attachment region. In cartilage, aggrecan forms cartilage link protein stabilized aggregates with hyaluronan (HA). These aggregates contribute to the tissue's load bearing properties. Aggrecan and versican have a wide distribution in connective tissue and extracellular matrices. Neurocan is localized almost exclusively in nervous tissue. Aggregates having other CSPGs substituting for aggrecan may contribute to the structural integrity of many different tissues. There is considerable evidence that HA-binding CSPGs are involved in developmental processes in the central nervous system. Members of the vertebrate HPLN (hyaluronan/HA and proteoglycan binding link) protein family are physically linked adjacent to CSPG genes.
Statistics
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PSSM-Id: 319292
View PSSM: cd05714
Aligned: 3 rows
Threshold Bit Score: 185.865
Threshold Setting Gi: 130310
Created: 4-Sep-2007
Updated: 18-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2506816     36 LSGKVSLPCHFstmptlppsyntsefLRIKWSkievdkngkDLKE-TTVLVAqngnikigqdykgrvSVPTHPEAVGDAS 114
gi 130310      53 RGGNVTLPCKFyrdptaf--gsgihkIRIKWTklt----sdYLKE-VDVFVSmgyhkkt--yggyqgRVFLKGGSDSDAS 123
gi 160332364   51 LAELVALPCLFtlqprp---saardaPRIKWTkvr---tasGQRQdLPILVAkdnvvrvakswqgrvSLPSYPRRRANAT 124
                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 2506816    115 LTVvkLLASDAGLYRCDVMYGIEDTQDTVSLTVDGVV 151
gi 130310     124 LVItdLTLEDYGRYKCEVIEGLEDDTVVVALDLQGVV 160
gi 160332364  125 LLLgpLRASDSGLYRCQVVRGIEDEQDLVPLEVTGVV 161
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