1NEU


Conserved Protein Domain Family
Ig_P0-like

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cd05715: Ig_P0-like 
Click on image for an interactive view with Cn3D
Immunoglobulin (Ig)-like domain of Protein zero (P0) and similar proteins
Ig_P0ex-like: domain similar to the immunoglobulin (Ig) domain of Protein zero (P0), a myelin membrane adhesion molecule. P0 accounts for over 50% of the total protein in peripheral nervous system (PNS) myelin. P0 is a single-pass transmembrane glycoprotein with a highly basic intracellular domain and an extracellular Ig domain. The extracellular domain of P0 (P0-ED) is similar to the Ig variable domain, carrying one acceptor sequence for N-linked glycosylation. P0 plays a role in membrane adhesion in the spiral wraps of the myelin sheath. The intracellular domain is thought to mediate membrane apposition of the cytoplasmic faces and may, through electrostatic interactions, interact directly with lipid headgroups. It is thought that homophilic interactions of the P0 extracellular domain mediate membrane juxtaposition in the extracellular space of PNS myelin. This group also contains the Ig domain of Sodium channel subunit beta-2 (SCN2B), and of epithelial V-like antigen 1 (EVA). EVA, also known as myelin protein zero-like 2, is an adhesion molecule, which may play a role in structural organization of the thymus and early lymphocyte development. SCN2B subunits play a role in determining sodium channel density and function in neurons,and in control of electrical excitability in the brain.
Statistics
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PSSM-Id: 319293
View PSSM: cd05715
Aligned: 6 rows
Threshold Bit Score: 194.958
Threshold Setting Gi: 94958223
Created: 12-Sep-2007
Updated: 18-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
 
tetramer
Conserved site includes 9 residues -Click on image for an interactive view with Cn3D
Feature 1:tetramer interface [polypeptide binding site]
Evidence:
  • Comment:Tetrameric association of P0ex domains inferred from crystal contacts and supported by analytical ultracentrifugation.
  • Citation:PMID 8816707
  • Comment:P0ex tetramer is comprised of four molecules arranged around a central hole.
  • Comment:P0ex domains, may come from one membrane surface as tetramers, that link to POex tetramers from the opposing membrane surface.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1        # #           #       # #                                            #  #       
1NEU_A         2 VVYTDREVYGAVGSQVTLHCSFWSSewv-sddISFTWRyqpeggrdaISIFHYakgqpyi--devgtfkERIQWVGDPSW 78
gi 94958223   35 DVLVPALINALNGSDVRITCTFTSCykldpskFAMNWTyqet-snstEEMFMTykntykmiplkpsrfgERVMFTGNLDK 113
gi 20137696   28 EIYTSRVLEAVNGTDARLKCTFSSFapv-gdaLTVTWNfrpldggpeQFVFYYhidpfqp---msgrfkDRVSWDGNPER 103
gi 12229743   31 EVTVPATLNVLNGSDARLPCTFNSCytvnhkqFSLNWTyqec-nncsEEMFLQfrmkiin--lklerfqDRVEFSGNPSK 107
gi 74762127   39 EVYTPKEIFVANGTQGKLTCKFKSTstt-gglTSVSWSfqpegadttVSFFHYsqgqvyl--gnyppfkDRISWAGDLDK 115
gi 118083692  21 EVTTPEEMFVENETDVKLPCTFTSAevi-ssaASVSWSfqpegaatrISFFYYsngkpyt--gkdipfkDRVTWAGDLNK 97
                         90       100       110
                 ....*....|....*....|....*....|....*....
Feature 1               ##                              
1NEU_A        79 KDGSIVIHNLDYSDNGTFTCDVKNPPDivgKTSQVTLYV 117
gi 94958223  114 NDLSITISDVQLTDEGIYNCYVRNPPDriqGHGTIQFAV 152
gi 20137696  104 YDASILLWKLQFDDNGTYTCQVKNPPDvdgVIGEIRLSV 142
gi 12229743  108 YDVSVMLRNVQPEDEGIYNCYIMNPPDrhrGHGKIHLQV 146
gi 74762127  116 KDASINIENMQFIHNGTYICDVKNPPDivvQPGHIRLYV 154
gi 118083692  98 KDASISISNMQFQDNGTYICDVKNPPDivvKPGEIRLRV 136

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