1XED,2OCW,1ZOX,2OCW,2OCW,2OCW,2Q87,2NMS,1HKF


Conserved Protein Domain Family
Ig_pIgR_like

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cd05716: Ig_pIgR_like 
Click on image for an interactive view with Cn3D
Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar domains
Ig_pIgR: Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar domains. pIgR delivers dimeric IgA and pentameric IgM to mucosal secretions. Polymeric immunoglobulin (pIgs) are the first defense against pathogens and toxins. IgA and IgM can form polymers via an 18-residue extension at their c-termini referred to as the tailpiece. pIgR transports pIgs across mucosal epithelia into mucosal secretions. Human pIgR is a glycosylated type I transmembrane protein, comprised of a 620 residue extracellular region, a 23 residue transmembrane region, and a 103 residue cytoplasmic tail. The extracellular region contains five domains that share sequence similarity with Ig variable (v) regions. This group also contains the Ig-like extracellular domains of other receptors such as NK Cell Receptor Nkp44 and myeloid receptors, among others.
Statistics
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PSSM-Id: 143193
View PSSM: cd05716
Aligned: 32 rows
Threshold Bit Score: 73.2469
Threshold Setting Gi: 189515365
Created: 16-Aug-2007
Updated: 18-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
 
CDR1-dIgA
Conserved site includes 3 residues -Click on image for an interactive view with Cn3D
Feature 1:CDR1-dIgA binding residues [polypeptide binding site]
Evidence:
  • Comment:Identified via mutation studies of the CDR1 region. Point mutations of these residues and others in the neighboring non-conserved CDR1 reduce or abolish binding to dIgA.
  • Comment:In addition to CDR1, the other two CDR loops appear to be involved in the interaction with antibody.
  • Citation:PMID 7989333

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                  ###                                                    
1XED_A          9 EVNSVEGNSVSITCYyppts-vnrhTRKYWCrqgarggcitli--ssegyvsskyagRANLTNFpe--------ngTFVV 77
2OCW_A        340 VVKGVAGSSVAVLCPynrk---eskSIKYWClwegaqngrcpllvdsegwvkaqyegRLSLLEEpg--------ngTFTV 408
gi 130200     356 VLKGFPGGSVTIRCPynpkrsdshlQLYLWEgsqtrhllvds----geglvqkdytgRLALFEEpg--------ngTFSV 423
gi 118102431  246 FLHGRLGGSLSLRCHhnpv---gsyTTKYLCrwqeascsllvd--tdgfvhesykgrIWISNSEqd--------sgTYTV 312
gi 118102431  136 LHLGELRGSITIPCPpgds---wggTRRLWCrvgrsrciliad---tdgyvgksyegRICITPQes--------sgAFKV 201
gi 33340035   257 TIFGVKGSSATIDCHydpt---knySLKYLCkwrttgcariid---ntgflpgpyegRVAMFDNpk--------ngTFSI 322
gi 63024875    21 LISGHRGERLDIRCPyksg---yesNPKYFCkgkcnygykni----vvksgspakdeRFSLTDDkr--------srVFTI 85
gi 47207698   160 AQTVKTAAGETVPCDpprw---gamSELFFCkensntcaem-------lstrssertIGSFTLKet--------dgNFSI 221
gi 189515365  374 PVVRREGESAQIFCPydsi---yqsKSKSLCkgkcstrdtrp-----ldetvreekeRLTLHEDvt--------asVFTG 437
gi 189515365  111 TESVHLGGEVKISCQip------eeQKVLFCkeeynq---------------scqktRASEDPQltragsvggeerVFTV 169
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
Feature 1                                                 
1XED_A         78 NIAqlsQDDSGRYKCGLGins---------rglSFDVSLE 108
2OCW_A        409 ILNqltSRDAGFYWCLTNgdt---------lwrTTVEIKI 439
gi 130200     424 VLNqltAEDEGFYWCVSDdde----------slTTSVKLQ 453
gi 118102431  313 VMShlrEEDAGWYWCVARnrh---------rehTTSMKLR 343
gi 118102431  202 LINdlrLDDAGLYKCGMGspadwd----swqlvALQVTTV 237
gi 33340035   323 VLNqlsSRDEGFYWCMTDdhre--------rrtSKELKIV 354
gi 63024875    86 SITdlrTEDEGQYWCVVKktlftt---dvyteiLLLVKQD 122
gi 47207698   222 FISqasSRDNGVYWCASKtelyra----glqkiTIKVKDR 257
gi 189515365  438 TITgltAEDAGKYWCAVTldrel-----nylytHLMVIIK 472
gi 189515365  170 SISnvsVRDAGVYWCGAEtrdthltfislttkiQLSVITK 209

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