1DGI


Conserved Protein Domain Family
Ig2_PVR_like

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cd05719: Ig2_PVR_like 
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Second immunoglobulin (Ig) domain of poliovirus receptor (PVR, also known as CD155) and similar proteins
Ig2_PVR_like: domain similar to the second immunoglobulin (Ig) domain of poliovirus receptor (PVR, also known as CD155). Poliovirus (PV) binds to its cellular receptor (PVR/CD155) to initiate infection. CD155 is a membrane-anchored, single-span glycoprotein; its extracellular region has three Ig-like domains. There are four different isotypes of CD155 (referred to as alpha, beta, gamma, and delta), these result from alternate splicing of the CD155 mRNA, and have identical extracellular domains. CD155-beta and - gamma, are secreted, CD155-alpha and delta are membrane-bound and function as PV receptors. The virus recognition site is contained in the amino-terminal domain, D1. Having the virus attachment site on the receptor distal from the plasma membrane may be important for successful initiation of infection of cells by the virus. CD155 binds in the poliovirus "canyon", it has a footprint similar to that of the intercellular adhesion molecule-1 receptor on human rhinoviruses. This group also includes the second Ig-like domain of nectin-1 (also known as poliovirus receptor related protein(PVRL)1; CD111).
Statistics
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PSSM-Id: 319296
View PSSM: cd05719
Aligned: 4 rows
Threshold Bit Score: 127.708
Threshold Setting Gi: 74761016
Created: 18-Sep-2007
Updated: 18-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1DGI_R       118 PQNTAEVQkvql-----tgepVPMARCVSTgGRPPAQITWHsd--------lgGMPNTSQVPGFlsgTVTVTSLWILVps 184
gi 118101917 611 PTNRMEGTtrpliaksgrtekILVATCISSnGKPPSTVTWDtk--------lkGEAEFQEIRNSn-gTFTVISRYRLVps 681
gi 74761016  149 PLPSLNPGpalee----gqglTLAASCTAE-GSPAPSVTWDte--------vkGTTSSRSFKHSr--SAAVTSEFHLVps 213
gi 1173371   143 PEILHQADflet------eklKMLGECVVRdSYPEGNVTWYkngrvlqpveevVVINLRKVENRstgLFTMTSSLQYMpt 216
                         90       100
                 ....*....|....*....|....*....
1DGI_R       185 sqVDGKNVTCKVEHESfeKPQLLTVNLTV 213
gi 118101917 682 reAHRQQLMCVVNYQL--DRFTDSITLNV 708
gi 74761016  214 rsMNGQPLTCVVSHPGllQDQRITHILHV 242
gi 1173371   217 keDANAKFTCIVTYHGp-SGQKTIQSEPV 244
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