2V9Q,2VRA


Conserved Protein Domain Family
Ig2_Robo

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cd05724: Ig2_Robo 
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Second immunoglobulin (Ig)-like domain in Robo (roundabout) receptors
Ig2_Robo: domain similar to the second immunoglobulin (Ig)-like domain in Robo (roundabout) receptors. Robo receptors play a role in the development of the central nervous system (CNS), and are receptors of Slit protein. Slit is a repellant secreted by the neural cells in the midline. Slit acts through Robo to prevent most neurons from crossing the midline from either side. Three mammalian Robo homologs (robo1, -2, and -3), and three mammalian Slit homologs (Slit-1,-2, -3), have been identified. Commissural axons, which cross the midline, express low levels of Robo; longitudinal axons, which avoid the midline, express high levels of Robo. robo1, -2, and -3 are expressed by commissural neurons in the vertebrate spinal cord and Slits 1, -2, -3 are expressed at the ventral midline. Robo-3 is a divergent member of the Robo family which instead of being a positive regulator of slit responsiveness, antagonizes slit responsiveness in precrossing axons. The Slit-Robo interaction is mediated by the second leucine-rich repeat (LRR) domain of Slit and the two N-terminal Ig domains of Robo, Ig1 and Ig2. The primary Robo binding site for Slit2 has been shown by surface plasmon resonance experiments and mutational analysis to be is the Ig1 domain, while the Ig2 domain has been proposed to harbor a weak secondary binding site.
Statistics
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PSSM-Id: 143201
View PSSM: cd05724
Aligned: 8 rows
Threshold Bit Score: 150.238
Threshold Setting Gi: 178847385
Created: 19-Jul-2007
Updated: 18-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2V9Q_A        116 QNPSDVMVAVGePAVMECQPPRGhPEPTISWKKDGSPLddk-------deRITIRg--GKLMItytrksDAGKYVCVGTN 186
2VRA_A        113 VEPKDTRVAKGeTALLECGPPKGiPEPTLIWIKDGVPLddlkamsfgassRVRIVd-gGNLLIsnvepiDEGNYKCIAQN 191
gi 72003712   137 VRPRTVQALGGeMAVLECSPPRGfPEPVVSWRKDDKELriq-------dmPRYTLhsdGNLIIdpvdrsDSGTYQCVANN 209
gi 115774534  248 QEPSDTMALLGeAVVLECSPPRGhPEPEVSWERNGQTVved-------giRVRILt-dGNLVIsqpkssDIGNYVCVATN 319
gi 17511435   141 IQPRDMVAVVGeQFTLECGPPWGhPEPTVSWWKDGKPLal--------qpGRHTVs-gGSLLMaraeksDEGTYMCVATN 211
gi 54650644    70 LEPANTRVAQGeVALMECGAPRGsPEPQISWRKNGQTLnlv------gnkRIRIVd-gGNLAIqearqsDDGRYQCVVKN 142
gi 134085226  177 VQPSDVEVAIGeMATINCSPPVGhPEPNVTWRKDGILInss-------neHYTELk--GKLIIapaqknDSGVYSCIASN 247
gi 115934044  124 EEPVSDQLISGdSAVLECTPPRGyPTPEVTWLKDDQPIild-------nnRVKIVe-dGNLLLkelrkdDEGTYKCKAQN 195
                          90
                  ....*....|....
2V9Q_A        187 MVGERESEVAELTV 200
2VRA_A        192 LVGTRESSYAKLIV 205
gi 72003712   210 MVGERVSNPARLSV 223
gi 115774534  320 SEGAKRSAAGRLII 333
gi 17511435   212 SAGHRESRAARVSI 225
gi 54650644   143 VVGTRESATAFLKV 156
gi 134085226  248 MIGVRESRAARLSV 261
gi 115934044  196 VAGERISKDAYLTV 209
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