1CS6,2OM5


Conserved Protein Domain Family
Ig2_Contactin-2-like

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cd05727: Ig2_Contactin-2-like 
Click on image for an interactive view with Cn3D
Second Ig domain of the neural cell adhesion molecule contactin-2 and similar proteins
Ig2_Contactin-2-like: second Ig domain of the neural cell adhesion molecule contactin-2. Contactins are comprised of six Ig domains followed by four fibronectin type III (FnIII) domains anchored to the membrane by glycosylphosphatidylinositol. Contactin-2 (aliases TAG-1, axonin-1) facilitates cell adhesion by homophilic binding between molecules in apposed membranes. The first four Ig domains form the intermolecular binding fragment which arranges as a compact U-shaped module by contacts between Ig domains 1 and 4, and domains 2 and 3. It has been proposed that a linear zipper-like array forms, from contactin-2 molecules alternatively provided by the two apposed membranes.
Statistics
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PSSM-Id: 143204
View PSSM: cd05727
Aligned: 5 rows
Threshold Bit Score: 170.043
Threshold Setting Gi: 20152017
Created: 26-Jun-2007
Updated: 18-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
 
domain-domain
Conserved site includes 4 residues -Click on image for an interactive view with Cn3D
Feature 1:domain-domain interface [polypeptide binding site]
Evidence:
  • Structure:1CS6_A; Gallus gallus axonin-1 Ig2 and Ig3 interface, contacts based on 3.5 A distance.
    View structure with Cn3D
  • Comment:Anoxin-1 domains Ig2 and Ig3 interact with each other, helping to form the U-shaped axonin structure.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                             #                              #  # #                       
1CS6_A         99 FLQEFSAEERDPVKITegwGVMFTCSPPPHYPa-LSYRWLLNEFPNFipaDGRRFVSqttGNLYIakteaSDLGNYSCFA 177
2OM5_A         98 FLQEFSKEERDPVKAHegwGVMLPCNPPAHYPg-LSYRWLLNEFPNFiptDGRHFVSqttGNLYIartnaSDLGNYSCLA 176
gi 116918     134 YLDPFPPEERPEVKVKegkGMVLLCDPPYHFPddLSYRWLLNEFPVFitmDKRRFVSqtnGNLYIanvesSDRGNYSCFV 213
gi 147898733  118 YLDPFPTEERYEVKVKegtGAVLICDPPPHVPddLNYRWLLNEFPVFlspDNRRFVTqtnGNLYIakvehLDRGNYSCFV 197
gi 20152017   112 FIMEFNLKRSAETSEMn-wGKSIFCDPPQHYPd-VRYYWARDYFPNFveeDQRVFVSr-dGALYFsfietVDRANYSCTV 188
                          90
                  ....*....|....*....
Feature 1                            
1CS6_A        178 TSHidfiTKSVFSKFSQLS 196
2OM5_A        177 TSHmdfsTKSVFSKFAQLN 195
gi 116918     214 SSPs--iTKSVFSKFIPLI 230
gi 147898733  198 SSPs--vTKSVFSKFISLL 214
gi 20152017   189 QTLv--sDTGRNGPFFPLR 205

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