1CS6,2OM5


Conserved Protein Domain Family
Ig4_Contactin-2-like

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cd05728: Ig4_Contactin-2-like 
Click on image for an interactive view with Cn3D
Fourth Ig domain of the neural cell adhesion molecule contactin-2 and similar proteins
Ig4_Contactin-2-like: fourth Ig domain of the neural cell adhesion molecule contactin-2. Contactins are comprised of six Ig domains followed by four fibronectin type III (FnIII) domains anchored to the membrane by glycosylphosphatidylinositol. Contactin-2 (aliases TAG-1, axonin-1) facilitates cell adhesion by homophilic binding between molecules in apposed membranes. The first four Ig domains form the intermolecular binding fragment which arranges as a compact U-shaped module by contacts between Ig domains 1 and 4, and domains 2 and 3. It has been proposed that a linear zipper-like array forms, from contactin-2 molecules alternatively provided by the two apposed membranes.
Statistics
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PSSM-Id: 143205
View PSSM: cd05728
Aligned: 5 rows
Threshold Bit Score: 172.4
Threshold Setting Gi: 31980846
Created: 26-Jun-2007
Updated: 18-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
 
domain-domain
Conserved site includes 4 residues -Click on image for an interactive view with Cn3D
Feature 1:domain-domain interface [polypeptide binding site]
Evidence:
  • Structure:1CS6_A; Gallus gallus axonin-1 Ig1 and Ig4 interaction, contacts based on 3.5 A distance.
    View structure with Cn3D
  • Comment:Anoxin-1 domains Ig1 and Ig4 interact with each other, helping to form the U-shaped axonin structure.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                          #                              # #             
1CS6_A        296 DWLDVITDTEADigsDLRWSCVAsGKPRPAVRWLrdGQPLASQnrIEVSgGELRFsklvLEDSGMYQCVAENKHGTVYAS 375
2OM5_A        295 EWLKVISDTEADigsNLRWGCAAaGKPRPTVRWLrnGEPLASQnrVEVLaGDLRFsklsLEDSGMYQCVAENKHGTIYAS 374
gi 47227360   297 QWVHTPKDADIAigaSLQWECKAmGNPRPAYKWLknGQILPKEgeIYVEaGKLSItrisLSDSGMYQCVAHNEHGSVYAS 376
gi 31980846   319 EWEQKIQNTYLSiydSLFWECKAsGNPNPSYTWLknGQRLNTEerIQIEnGTLIItmlnISDSGIYQCAAENKYQTIYAN 398
gi 120538513  328 EWLKVISDTEADigsNLRWGCAAaGKPRPTVRWLrnGEPLASQnrVEVLaGDLRFsklsLEDSGMYQCVAENKHGTIYAS 407

                  ....*
Feature 1          #   
1CS6_A        376 AELTV 380
2OM5_A        375 AELAV 379
gi 47227360   377 AELKV 381
gi 31980846   399 AELRV 403
gi 120538513  408 AELAV 412

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