1E0O


Conserved Protein Domain Family
Ig2_FGFR_like

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cd05729: Ig2_FGFR_like 
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Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor and similar proteins
Ig2_FGFR_like: domain similar to the second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor. FGF receptors bind FGF signaling polypeptides. FGFs participate in multiple processes such as morphogenesis, development, and angiogenesis. FGFs bind to four FGF receptor tyrosine kinases (FGFR1, -2, -3, -4). Receptor diversity is controlled by alternative splicing producing splice variants with different ligand binding characteristics and different expression patterns. FGFRs have an extracellular region comprised of three Ig-like domains, a single transmembrane helix, and an intracellular tyrosine kinase domain. Ligand binding and specificity reside in the Ig-like domains 2 and 3, and the linker region that connects these two. FGFR activation and signaling depend on FGF-induced dimerization, a process involving cell surface heparin or heparin sulfate proteoglycans. This group also contains fibroblast growth factor (FGF) receptor_like-1(FGFRL1). FGFRL1 does not have a protein tyrosine kinase domain at its C terminus; neither does its cytoplasmic domain appear to interact with a signaling partner. It has been suggested that FGFRL1 may not have any direct signaling function, but instead acts as a decoy receptor trapping FGFs and preventing them from binding other receptors.
Statistics
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PSSM-Id: 319297
View PSSM: cd05729
Aligned: 3 rows
Threshold Bit Score: 145.053
Threshold Setting Gi: 45383249
Created: 10-Aug-2007
Updated: 18-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
 
FGF bindingligand binding
Conserved site includes 3 residues -Click on image for an interactive view with Cn3D
Feature 1:FGF binding site [polypeptide binding site]
Evidence:
  • Structure:1E0O_B; human FGF1-FGFR2 interaction interface defined by 3.5A distance.
    View structure with Cn3D
  • Comment:The FGF1-FGFR2-heparin complex is comprised of one heparin molecule linked to two FGF1 molecules, each FGF1 molecule of which is bound to a receptor ectodomain. Shown here is one FGF1 molecule bound to the receptor ectodomain.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1         # # #                                                                         
1E0O_B       17 KRLHAVPAANTVKFRCPAGgnPMPTMRWLKNgkefkqehriggYKVRnqhWSLIMESVVPSDKGNYTCVVENeYGSINHT 96
gi 74835189 291 EPEKPLPSNTKVRLECGARgtPTPNITWIKDgvqkwkinvirpTRVEekgFVLIIRRAIVRDTGKYTCIVSNqYGTIEHT 370
gi 45383249 151 RRVIARPVGSSIRLKCVASgnPRPDITWLKDnkplm---pheiGENKkkkWTLNLKNLKPEDSGKYTCRVFNkVGEINAT 227

                ....*
Feature 1            
1E0O_B       97 YHLDV 101
gi 74835189 371 YDVKI 375
gi 45383249 228 YKVEV 232

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