Conserved Protein Domain Family
Ig3_L1-CAM_like

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cd05731: Ig3_L1-CAM_like 
Third immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM)
Ig3_L1-CAM_like: domain similar to the third immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM). L1 belongs to the L1 subfamily of cell adhesion molecules (CAMs) and is comprised of an extracellular region having six Ig-like domains and five fibronectin type III domains, a transmembrane region and an intracellular domain. L1 is primarily expressed in the nervous system and is involved in its development and function. L1 is associated with an X-linked recessive disorder, X-linked hydrocephalus, MASA syndrome, or spastic paraplegia type 1, that involves abnormalities of axonal growth. This group also contains the chicken neuron-glia cell adhesion molecule, Ng-CAM and human neurofascin.
Statistics
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PSSM-Id: 319298
View PSSM: cd05731
Aligned: 8 rows
Threshold Bit Score: 131.398
Threshold Setting Gi: 1171701
Created: 11-Jul-2007
Updated: 18-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 134025431  262 LQLECIAEGLPTPEIEWIPLLGstyneriqfdDFKKTLHIDKVqDEDDGDYQCIAKNTQGSsSHTFTVVVE 332
gi 1171701    256 VVLECIAEGLPTPWVRWRRLNGpllp--ggvgNFNKTLRLWGVtESDDGEYECVAENGRGTaRGTHSVTVE 324
gi 118097056  275 LQLECIAEGLPTPHLSWVKVTGslpkdkpvtdKFGKVLKIENVsAADEGTYQCTASNPVGRaKHEFHVHVE 345
gi 113679606  282 LELECIADGLPTPNISWTKVNGelpsgrfsfySFQKTLKIKEVtEADGGDYRCIAKNRMGSsQHTITVVVR 352
gi 83304988   264 LLLECIASGVPTPDIAWYKKGGdlpsdkakfeNFNKALRITNVsEEDSGEYFCLASNKMGSiRHTISVRVK 334
gi 462740     264 LLLECIAAGLPTPVIRWIKEGGelpanrtffeNFKKTLKIIDVsEADSGNYKCTARNTLGStHHVISVTVK 334
gi 229462991  258 LLLECFAEGLPTPQVDWNKIGGdlpkgretkeNYGKTLKIENVsYQDKGNYRCTASNFLGTaTHDFHVIVE 328
gi 237858639  265 LLLECIASGVPAPDIMWYKKGGelpagktkleNFNKALRISNVsEEDSGEYFCLASNKMGSiRHTISVRVK 335
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