2VA4


Conserved Protein Domain Family
Ig_NCAM-1_like

?
cd05732: Ig_NCAM-1_like 
Click on image for an interactive view with Cn3D
Immunoglobulin (Ig)-like domain of Neural Cell Adhesion Molecule NCAM-1 (NCAM) and similar proteins
Ig_NCAM-1 like: domain similar to the fourth immunoglobulin (Ig)-like domain of Neural Cell Adhesion Molecule NCAM-1 (NCAM). NCAM plays important roles in the development and regeneration of the central nervous system, in synaptogenesis and neural migration. NCAM mediates cell-cell and cell-substratum recognition and adhesion via homophilic (NCAM-NCAM), and heterophilic (NCAM-non-NCAM), interactions. NCAM is expressed as three major isoforms having different intracellular extensions. The extracellular portion of NCAM has five N-terminal Ig-like domains and two fibronectin type III domains. The double zipper adhesion complex model for NCAM homophilic binding involves Ig1, Ig2, and Ig3. By this model, Ig1 and Ig2 mediate dimerization of NCAM molecules situated on the same cell surface (cis interactions), and Ig3 domains mediate interactions between NCAM molecules expressed on the surface of opposing cells (trans interactions), through binding to the Ig1 and Ig2 domains. The adhesive ability of NCAM is modulated by the addition of polysialic acid chains to the fifth Ig-like domain. Also included in this group is NCAM-2 (also known as OCAM/mamFas II and RNCAM) NCAM-2 is differentially expressed in the developing and mature olfactory epithelium (OE).
Statistics
?
PSSM-Id: 143209
View PSSM: cd05732
Aligned: 7 rows
Threshold Bit Score: 173.096
Threshold Setting Gi: 18859063
Created: 17-Aug-2007
Updated: 18-Aug-2016
Structure
?
Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2VA4_A         94 VQPHIIQLKNETTYEn-gQVTLVCDAEGEPIPEITWKRAvdgFTFTEGDKSLDGRIEVKGQHGSSSLHIKDVKLSDSGRY 172
gi 2851523    306 AKPKITYVENKTAMEledQITLTCEASGDPIPSITWKTSt--RNISNEEKTLDGRIVVRSHARVSSLTLKEIQYTDAGEY 383
gi 119587605  306 AKPKITYVENQTAMEleeQVTLTCEASGDPIPSITWRTSt--RNISSEEKTLDGHMVVRSHARVSSLTLKSIQYTDAGEY 383
gi 134085234  298 VQPHITKLRNVTAVEg-sAAMISCKAEGEPLPEISWRRAsdgHSFSDGDKSPDGRVEVRGRYGESMLTIVVVKLSDWGRF 376
gi 118083771  315 VQPQIIQLKNETTFEn-gKATLICEAEGEPIPEITWKRAtdgITFSEGDKSPDGRIEVKGQHGKSSLHIKDVKLSDSGRY 393
gi 127855     301 AKPKITYVENKTAVEl-dEITLTCEASGDPIPSITWRTAv--RNISSEATTLDGHIVVKEHIRMSALTLKDIQYTDAGEY 377
gi 18859063   300 VQPKITFLENQTASEleeQITLTCEATGDPTPNIIWSFGr--RVFTENEQSLDGNVVVRSDARVSSLTLKYVQFTDAGQY 377
                          90
                  ....*....|....*....
2VA4_A        173 DCEAASRIGGHQKSMYLDI 191
gi 2851523    384 VCTASNTIGQDSQAMYLEV 402
gi 119587605  384 ICTASNTIGQDSQSMYLEV 402
gi 134085234  377 DCEALSRIGGHQKSMFLDI 395
gi 118083771  394 DCEAASRIGGHQKSMYLDI 412
gi 127855     378 FCIASNPIGVDMQAMYFEV 396
gi 18859063   378 LCTARNSIGQDIQSMYLEV 396
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap