Conserved Protein Domain Family
Ig_DSCAM

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cd05734: Ig_DSCAM 
Immunoglobulin (Ig)-like domain of Down Syndrome Cell Adhesion molecule (DSCAM)
Ig_DSCAM: immunoglobulin (Ig)-like domain of Down Syndrome Cell Adhesion molecule (DSCAM). DSCAM is a cell adhesion molecule expressed largely in the developing nervous system. The gene encoding DSCAM is located at human chromosome 21q22, the locus associated with the mental retardation phenotype of Down Syndrome. DSCAM is predicted to be the largest member of the IG superfamily. It has been demonstrated that DSCAM can mediate cation-independent homophilic intercellular adhesion.
Statistics
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PSSM-Id: 143211
View PSSM: cd05734
Aligned: 3 rows
Threshold Bit Score: 115.797
Threshold Setting Gi: 47213409
Created: 27-Jun-2007
Updated: 18-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 73620825   707 GVLNCSVDGYPPPKVMWKHAKGsGNPQQYHpvp----------------------------------ltGRIQILPNSSL 752
gi 118083919 1009 VILNCSAEGYPVPTIVWKYSKGaGVPQFQPia-----------------------------------lnGRIQLLTNGSL 1053
gi 47213409   749 VTLNCSAEGYPPPTIVWEHSKGrCHHTHTHtcctslirmegcseelvdvedggsprcppvpaggmtasaARALLLSNGSL 828
                          90       100       110
                  ....*....|....*....|....*....|....
gi 73620825   753 LIRHVLEEDi-GYYLCQASNGVGtDISKSMFLTV 785
gi 118083919 1054 LIKHVLEEDs-GYYLCKVSNDVGaDVSKSMYLTV 1086
gi 47213409   829 LIKHVLEDDseSMYLCKVSNDVGaDAQQVHVAHR 862
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