Conserved Protein Domain Family
Ig2_Follistatin_like

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cd05736: Ig2_Follistatin_like 
Second immunoglobulin (Ig)-like domain of a Follistatin-related protein 5 and similar proteins
Ig2_Follistatin_like: domain similar to the second immunoglobulin (Ig)-like domain found in human Follistatin-related protein 5 (FSTL5) and a follistatin-like molecule encoded by the CNS-related Mahya gene. Mahya genes have been retained in certain Bilaterian branches during evolution. They are conserved in Hymenoptera and Deuterostomes, but are absent from other metazoan species such as fruit fly and nematode. Mahya proteins are secretory, with a follistatin-like domain (Kazal-type serine/threonine protease inhibitor domain and EF-hand calcium-binding domain), two Ig-like domains, and a novel C-terminal domain. Mahya may be involved in learning and memory and in processing of sensory information in Hymenoptera and vertebrates. Follistatin is a secreted, multidomain protein that binds activins with high affinity and antagonizes their signaling.
Statistics
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PSSM-Id: 143213
View PSSM: cd05736
Aligned: 5 rows
Threshold Bit Score: 144.677
Threshold Setting Gi: 71979914
Created: 11-Jul-2007
Updated: 18-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 62510692  358 ASLRCHAEGIPKPQLGWLKNGIDitpKLSKQLTLQANGSEVHIsnVRYEDTGAYTCIAKNEAGVDEDISSLFVEDS 433
gi 126290227 323 ASLKCHAEGIPTPRITWLKNGMDvgpKLSKQLSLIANGSELHInsVRYEDTGAYTCIAKNEVGVDEDISSLFIEDS 398
gi 73611908  365 ASLRCYAEGIPDPQLSWLKNGMDittKLSKQLTLQANGSEVHIsnVHFEDTGAYTCIARNEAGVDEDISSLFVEDS 440
gi 45383161  357 ASLKCHAEGIPNPRITWLKNGMDimpKLSKQLTLLANGSELHIssVRYEDTGAYTCIAKNEVGVDEDISSLFIEDS 432
gi 71979914  419 ANIRCHVAGEPLPRVQWLKNDEAlnhDQPDKYDLIGNGTKLIIknVDYADTGAYMCQASSIGGITRDISSLVVQEQ 494
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