2R15


Conserved Protein Domain Family
Ig_Myomesin_like_C

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cd05737: Ig_Myomesin_like_C 
Click on image for an interactive view with Cn3D
C-temrinal immunoglobulin (Ig)-like domain of myomesin and M-protein
Ig_Myomesin_like_C: domain similar to the C-temrinal immunoglobulin (Ig)-like domain of myomesin and M-protein. Myomesin and M-protein are both structural proteins localized to the M-band, a transverse structure in the center of the sarcomere, and are candidates for M-band bridges. Both proteins are modular, consisting mainly of repetitive Ig-like and fibronectin type III (FnIII) domains. Myomesin is expressed in all types of vertebrate striated muscle; M-protein has a muscle-type specific expression pattern. Myomesin is present in both slow and fast fibers; M-protein is present only in fast fibers. It has been suggested that myomesin acts as a molecular spring with alternative splicing as a means of modifying its elasticity.
Statistics
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PSSM-Id: 319300
View PSSM: cd05737
Aligned: 4 rows
Threshold Bit Score: 175.857
Threshold Setting Gi: 73950614
Created: 11-Jul-2007
Updated: 18-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
 
dimerization
Conserved site includes 15 residues -Click on image for an interactive view with Cn3D
Feature 1:dimerization interface [polypeptide binding site]
Evidence:
  • Structure:2R15_A; human myomesin forms a tail-to-tail dimeric assembly, defined using 4.0 A contacts
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1              #########  #### # #                                                        
2R15_A        117 ARVLGGLPDVVTIQegKALNLTCNVWGDPPPEVSWLKNEKalaqTDHCNLKFEaGRTAYFTINgVSTADSGKYGLVVKNK 196
gi 73950614  1336 AKVVRGLPDVATIMedKTLCLTCVISGDPTPEISWLKNDQpvafLDRYRMEVR-GSEVTITIErVNSEDSGRYGVFVKNK 1414
gi 224471842 1344 GRLIGGLPDVVTIMegKTLNLTCTVFGNPDPEVIWFKNDQdiqlSEHFSVKVEqAKYVSMTIKgVTSEDSGKYSINIKNK 1423
gi 212276443 1572 ARVLGGLPDVVTIQegKALNLTCNVWGDPPPEVSWLKNEKalasDDHCNLKFEaGRTAYFTINgVSTADSGKYGLVVKNK 1651
                          90
                  ....*....|..
Feature 1                     
2R15_A        197 YGSETSDFTVSV 208
gi 73950614  1415 YGSETGQVTISV 1426
gi 224471842 1424 YGGEKIDVTVSV 1435
gi 212276443 1652 YGSETSDFTVSV 1663

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