2GK2,1L6Z,1Z2K,2DRU,1QA9,1HNG


Conserved Protein Domain Family
Ig_CEACAM_like

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cd05741: Ig_CEACAM_like 
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Immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM) and similar proteins
Ig_CEACAM_like: immunoglobulin (Ig)-like domain in carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM) and related domains. The CEA family is a group of anchored or secreted glycoproteins, expressed by epithelial cells, leukocytes, endothelial cells and placenta. The CEA family is divided into the CEACAM and pregnancy-specific glycoprotein (PSG) subfamilies. This group represents the CEACAM subfamily. CEACAM1 has many important cellular functions, it is a cell adhesion molecule, and a signaling molecule that regulates the growth of tumor cells, it is an angiogenic factor, and is a receptor for bacterial and viral pathogens, including mouse hepatitis virus (MHV). In mice, four isoforms of CEACAM1 generated by alternative splicing have either two [D1, D4] or four [D1-D4] Ig-like domains on the cell surface. This family corresponds to the D1 Ig-like domain. Also belonging to this group is the N-terminal immunoglobulin (Ig)-like domain of the signaling lymphocyte activation molecule (SLAM) family, CD84-like family. The SLAM family is a group of immune-cell specific receptors that can regulate both adaptive and innate immune responses. SLAM family proteins are organized as an extracellular domain with having two or four Ig-like domains, a single transmembrane segment, and a cytoplasmic region having tyr-based motifs. The extracellular domain is organized as a membrane-distal Ig variable (IgV) domain that is responsible for ligand recognition and a membrane-proximal truncated Ig constant-2 (IgC2) domain.
Statistics
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PSSM-Id: 319302
View PSSM: cd05741
Aligned: 41 rows
Threshold Bit Score: 66.943
Threshold Setting Gi: 160370002
Created: 12-Sep-2007
Updated: 18-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2GK2_A        18 GKEVLLLVHnlp-qqlFGYSWYkgervdgnrqivgya-igtqqatpgpansgRETIYPn-ASLLIQNVTQNDTGFYTLQV 94
2DRU_A        14 GSNVTLTILkhplasyQRLTWLhttnqkileyfpn-----gkktvfesvfkdRVDLDKtnGALRIYNVSKEDRGDYYMRM 88
1QA9_B        10 YGNVTFHVPsnq--plKEVLWKkqkdkvaelen--------sefrafssfknRVYLDTksGSLTIYNLTSSDEDEYEMES 79
gi 74006297   39 GSNVSLHISnlp--alSRVTWFytanqkivewes------nrtnffnskfknRASLDEs-YALCIYKVQKEDSSTYILRV 109
gi 114050785  36 GDNVTLHISnlp-knhKSLTWFyttdqkivewef------depmyfntkfknRATLHPqsGALFIRNIQKEDSSTYLLRV 108
gi 148277578  29 GGLITFTPSirg--kpVEILWKhngdkvveydn--------reieefgsfkdRVVIDFetGQLTIKKLTSQDSGQYQSDI 98
gi 31872399   38 HKNVTLRASssq--tlQEIIWKkgkdkaveweeq-------ynvtafppfvdRVHLNTgsGDLTIYNLAFEDEGDYQIES 108
gi 540537     38 NGNVTFYVSesq--pfTEIMWKkgkdkvvewdqt-------sgleafqsfknRVHLDIvsGNLTITGLTKLDEDVYEIES 108
gi 189534803   9 GDSVTLHTGvte-lhkGELTWHfiadkslialinrayeafstmdgpngrfrdRLKLDNntGSLTIINIRSEHAGVYEAQI 87
gi 189539169  34 RENVTLKTEtkl-legDEIQWWfsnenfliaeiieg--igetysgpkkrfsdCLELDKetGSLTIKNIRRKHTGDYRLKI 110
                         90
                 ....*....|....*.
2GK2_A        95 IksdlvnEEATGQFHV 110
2DRU_A        89 Lhe--teDQWKITMEV 102
1QA9_B        80 Pni---tDSMKFFLYV 92
gi 74006297  110 LkdsgkeEDWAISLEV 125
gi 114050785 109 LkdngdeKEWKISLMV 124
gi 148277578  99 Ting-kvQSSRHTLTV 113
gi 31872399  109 Psv---kNSSKFILRV 121
gi 540537    109 Psv---kKSSQFHLRV 121
gi 189534803  88 Fsd--ntSSKRFKVTV 101
gi 189539169 111 IkrsggtSNSKFSVHI 126
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