1NCT


Conserved Protein Domain Family
Ig_Titin_like

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cd05747: Ig_Titin_like 
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Immunoglobulin (Ig)-like domain of human titin C terminus and similar domains
Ig_Titin_like: domain similar to the M5, fifth immunoglobulin (Ig)-like domain from the human titin C terminus. Titin (also called connectin) is a fibrous sarcomeric protein specifically found in vertebrate striated muscle. Titin is gigantic; depending on isoform composition it ranges from 2970 to 3700 kDa, and is of a length that spans half a sarcomere. Titin largely consists of multiple repeats of Ig-like and fibronectin type 3 (FN-III)-like domains. Titin connects the ends of myosin thick filaments to Z disks and extends along the thick filament to the H zone, and appears to function similar to an elastic band, keeping the myosin filaments centered in the sarcomere during muscle contraction or stretching.
Statistics
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PSSM-Id: 143224
View PSSM: cd05747
Aligned: 3 rows
Threshold Bit Score: 168.688
Threshold Setting Gi: 157832088
Created: 17-Aug-2007
Updated: 18-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1NCT_A         12 TLAARILTKPRSMTVYEGESARFSCDTDGEPVPTVTWLRKGQVLSTSARHQVTTTKYKSTFEISSVQasDEGNYSVVVEN 91
gi 94732358 21358 TLPATILTKPQSLTVSEGESVKFTCDVDGEPAPSVTWMREAQIIVSSQRHLITSTEYKSTFEINKVEmsDGGNYTVVVEN 21437
gi 1777308    325 TLPATILTKPRSITVSEGETARFSCDVDGEPAPTITWVRAGQPIVSSRRFQITRTQYKSTFEISLVQiaDEGSYTVVVEN 404
                          90
                  ....*....|..
1NCT_A         92 SEGkQEAEFTLT 103
gi 94732358 21438 SEGkQEAQFSLT 21449
gi 1777308    405 SEGrQEAHFTLT 416
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