1GXE,2ILL,1WIT


Conserved Protein Domain Family
Ig_Titin_like

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cd05748: Ig_Titin_like 
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Immunoglobulin (Ig)-like domain of titin and similar domains
Ig_Titin_like: immunoglobulin (Ig)-like domain found in titin-like proteins. Titin (also called connectin) is a fibrous sarcomeric protein specifically found in vertebrate striated muscle. Titin is a giant protein; depending on isoform composition, it ranges from 2970 to 3700 kDa, and is of a length that spans half a sarcomere. Titin largely consists of multiple repeats of Ig-like and fibronectin type 3 (FN-III)-like domains. Titin connects the ends of myosin thick filaments to Z disks and extends along the thick filament to the H zone. It appears to function similarly to an elastic band, keeping the myosin filaments centered in the sarcomere during muscle contraction or stretching. Within the sarcomere, titin is also attached to or is associated with myosin binding protein C (MyBP-C). MyBP-C appears to contribute to the generation of passive tension by titin, and similar to titin has repeated Ig-like and FN-III domains. Also included in this group are worm twitchin and insect projectin, thick filament proteins of invertebrate muscle, which also have repeated Ig-like and FN-III domains.
Statistics
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PSSM-Id: 319305
View PSSM: cd05748
Aligned: 44 rows
Threshold Bit Score: 78.4152
Threshold Setting Gi: 33356956
Created: 27-Sep-2007
Updated: 18-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1GXE_A          35 KLRLDVPISGDPAPTVIWQkaitqgnkaparpapdapedtgdsdewvfdkkllcetegrvRVETTKDRSIFTVega--ek 112
gi 21388656   2080 PLDIPVGVSGTPTPTVSWEkngrp-------------------------------vdnraKCTSSEEDAKLHVdka--er 2126
gi 89243264   4359 DFSIHVPYVGFPKPTASWYsndtvl-----------------------------dddqrvHQHLTDEAASFVVkns--kr 4407
gi 108861911 29591 PFTIDVPISGRPAPKVTWKleemrl-----------------------------ketdrvSITTTKDRTTLTVkds--mr 29639
gi 115624453   953 KFEINLPLTGFPTPTATWElgsspv-----------------------------kesgrvLVTTARTYTKLKVdsa--er 1001
gi 115681464  8188 SFRIEVPYTGIPTPAVTWSfdgrpl-----------------------------kpsahiRIDTSNRASTITVknv--ek 8236
gi 126332399  1033 ALCIHASFYGSPPPTVIWQkdgip-------------------------------tkgreTITKGKNHSQFLInst--kr 1079
gi 108861911 19145 TIRLEAGVRGKPFPEVAWTkdkdatd---------------------------ltrsprvKIDTRADSSKFSLtka--kr 19195
gi 6898        702 TIKYDVPISGEPLPECLWVvngkp-------------------------------lkavgRVKMSSERGKHIMkienavr 750
gi 6898        998 TVRWEVKIGGEPIPEVKWFkgnqql-----------------------------engiqlTIDTRKNEHTILCipsa-mr 1047
                           90       100
                   ....*....|....*....|....*
1GXE_A         113 eDEGVYTVTVKNpvGEDQVNLTVKV 137
gi 21388656   2127 gDTGKYTITVTNesGSMSADVNVIV 2151
gi 89243264   4408 sDSGQYRLQLKNpsGFDTATINVKV 4432
gi 108861911 29640 gDSGRYFLTLENtaGVKTFSVTVVV 29664
gi 115624453  1002 qDAGRYTITVKNdsGSDTARVKVTV 1026
gi 115681464  8237 aNGGRYTINLKNtaGAESLDVEVRV 8261
gi 126332399  1080 sDSGVYRILLRNeyGEAHYDIHVRV 1104
gi 108861911 19196 sDGGKYVVTATNtaGSFVAYATVNV 19220
gi 6898        751 aDSGKFTITLKNssGSCDSTATVTV 775
gi 6898       1048 sDVGEYRLTVKNshGADEEKANLTV 1072
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