2C5D,1RHF


Conserved Protein Domain Family
Ig2_Axl_Tyro3_like

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cd05749: Ig2_Axl_Tyro3_like 
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Second immunoglobulin (Ig)-like domain of Axl/Tyro3 family receptor tyrosine kinases (RTKs)
Ig2_Tyro3_like: the second immunoglobulin (Ig)-like domain in the Axl/Tyro3 family of receptor tyrosine kinases (RTKs). This family includes Axl (also known as Ark, Ufo, and Tyro7), Tyro3 (also known as Sky, Rse, Brt, Dtk, and Tif), and Mer (also known as Nyk, c-Eyk, and Tyro12). Axl/Tyro3 family receptors have an extracellular portion with two Ig-like domains followed by two fibronectin-types III (FNIII) domains, a membrane-spanning single helix, and a cytoplasmic tyrosine kinase domain. Axl, Tyro3 and Mer are widely expressed in adult tissues, though they show higher expression in the brain, in the lymphatic and vascular systems, and in the testis. Axl, Tyro3, and Mer bind the vitamin K dependent protein Gas6 with high affinity, and in doing so activate their tyrosine kinase activity. Axl/Gas6 signaling may play a part in cell adhesion processes, prevention of apoptosis, and cell proliferation.
Statistics
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PSSM-Id: 143226
View PSSM: cd05749
Aligned: 7 rows
Threshold Bit Score: 143.382
Threshold Setting Gi: 47221063
Created: 27-Sep-2007
Updated: 18-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
 
ligand bindingdimerization
Conserved site includes 4 residues -Click on image for an interactive view with Cn3D
Feature 1:ligand binding site [chemical binding site]
Evidence:
  • Structure:2C5D_C, human receptor tyrosine kinase Tyro3 binds its activator Gas6 defined by 3.5A distance.
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                ### #   
2C5D_C       109 FLEEPEDRTVaanTPFNLSCQAQGPPEPVDLLWLQDavplata--pghgpqRSLHVPGlnkTSSFSCEAHNAKGVTTSRT 186
1RHF_A       101 FTVEPKDLAVppnAPFQLSCEAVGPPEPVTIVWWRGttkigg----papspSVLNVTGvtqSTXFSCEAHNLKGLASSRT 176
gi 45384492  189 FIQQPEKLNVtrnSPFNLTCQAVGPPEPVEIYWFRNnvqlnm---kpyispSVLTVPGlneTALFSCEAHNSKGLTASNP 265
gi 47221063  106 FSVEPQHMSVeanVSLSLSCVAHGPPEPVRVIWLQDgaplnaltdpvalspSTLNLTGlnrTSTFSCEAQNHKGVATSAS 185
gi 134054328 119 FGVEPEDVAAfagESFNLTCAASGPPEPVEVLWWLGgeqngd----ftpspSVLFVKGvneSIKFHCEAKNARGISVSRT 194
gi 148222039 127 FTLEPKDLSVtpnSPFNMTCAAVGPPEPLVIIWWVGdsplgk----sesspSVLQMSGiheRTAFSCEAHNAKGVSSSRT 202
gi 160332297 199 FTKQPESMNVtrnTAFNLTCQAVGPPEPVNIFWVQNssrvne---qpekspSVLTVPGlteMAVFSCEAHNDKGLTVSKG 275

                 ....
Feature 1            
2C5D_C       187 ATIT 190
1RHF_A       177 ATVH 180
gi 45384492  266 GQVN 269
gi 47221063  186 GTIT 189
gi 134054328 195 GTVH 198
gi 148222039 203 AIVE 206
gi 160332297 276 VQIN 279

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