1F6A,2FCB,3D5O


Conserved Protein Domain Family
Ig1_FcgammaR_like

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cd05752: Ig1_FcgammaR_like 
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Frst immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
Ig1_FcgammaR_like: domain similar to the first immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs). Interactions between IgG and FcgammaR are important to the initiation of cellular and humoral response. IgG binding to FcgammaR leads to a cascade of signals and ultimately to functions such as antibody-dependent-cellular-cytotoxicity (ADCC), endocytosis, phagocytosis, release of inflammatory mediators, etc. FcgammaR has two Ig-like domains. This group also contains FcepsilonRI, which binds IgE with high affinity.
Statistics
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PSSM-Id: 143229
View PSSM: cd05752
Aligned: 14 rows
Threshold Bit Score: 108.971
Threshold Setting Gi: 27805801
Created: 20-Sep-2007
Updated: 18-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
 
pentraxin
Conserved site includes 7 residues -Click on image for an interactive view with Cn3D
Feature 1:pentraxin binding site [polypeptide binding site]
Evidence:
  • Structure:3D5O_F; human FcgammaRIIa first Ig domain interacts with serum amyloid P component (SAP), forming contacts with three chains of the SAP pentamer. Site defined using 4.0 A contacts.
    View structure with Cn3D
  • Comment:Pentraxins, including SAP, are ancient conserved mediators of innate immunity that have been determined to interact with FcgammaRs to activate leukocyte-mediated phagocytosis.
  • Comment:Note that the pentameric SAP forms contacts with different but overlapping sets of residues in the first and second Ig domains of FcgammaRIIa. The first Ig domain forms contacts with three of the five SAP chains, while the second Ig domain forms contacts with two SAP chains.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1           ##                 #           ####                                          
1F6A_A         5 PKVSLNPPWnrIFKGENVTLTCNgnnf----fevSSTKWFHNgsls----eetnSSLNIvna-kfeDSGEYKCQHQqvaE 75
3D5O_F         5 AVLKLEPPWinVLQEDSVTLTCQgars----pesDSIQWFHNgnlip---thtqPSYRFkan--nnDSGEYTCQTGqtsL 75
gi 6978833    28 SVVSLDPPWirILTGDKVTLICNgnns----sqmNSTKWIHNdsis-----nvkSSHWVivsatiqDSGKYICQKQgfyK 98
gi 180162     22 AVITLQPPWvsVFQEETVTLHCEvlhl----pgsSSTQWFLNgtat----qtstPSYRItsa-svnDSGEYRCQRGlsgR 92
gi 126306222  25 AIVTLHPPWfsVLTKDLVTLRCNgsgt----pgyNSTRWLHNgaii----pvqsQDYNIrad-ttkYSGKYQCQTDqsaL 95
gi 109017425  25 AVLLLDPPWstAFKGEKVTLTCRgisq---sparGDTFWYRDeklw----kiqhNAIQIr------GSGNYQCKTQgssL 91
gi 126307386 111 AIVHLSPPWttIFQGEKVTLTCDgfn-----ssiPRTWWYKNeqrq-----ktrSTKSIvi----qQPGMYRCQNQdstL 176
gi 114560389  23 PVISVHPPWttFFKGERVTLTCNgfqf----yatEKTTWYHGhywgekltltagNTLEVr------ESGLYRCQARgspR 92
gi 126307396  21 ASVFISPPWttFFIGEKVFLTCDgfqf----yeqGKTQWYQNgkllq---eiseNNITIn------KSGKYRCKINnspL 87
gi 123228105  16 PILSLHPPWttIFKGERVTLKCDgyhplllelqpISTLWYLGhlll----pshkKSIEVq------TPGVYRCQTRgapV 85

                 ....*...
Feature 1                
1F6A_A        76 SEPVYLEV 83
3D5O_F        76 SDPVHLTV 83
gi 6978833    99 SKPVYLNV 106
gi 180162     93 SDPIQLEI 100
gi 126306222  96 SDPVRLEV 103
gi 109017425  92 SDAVHVEF 99
gi 126307386 177 SDPVHLVV 184
gi 114560389  93 SNPVRLLF 100
gi 126307396  88 SDIVKLTF 95
gi 123228105  86 SDPIHLSV 93

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