Conserved Protein Domain Family
Ig2_PTK7

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cd05760: Ig2_PTK7 
Second immunoglobulin (Ig)-like domain of protein tyrosine kinase (PTK) 7, also known as CCK4
Ig2_PTK7: domain similar to the second immunoglobulin (Ig)-like domain in protein tyrosine kinase (PTK) 7, also known as CCK4. PTK7 is a subfamily of the receptor protein tyrosine kinase family, and is referred to as an RPTK-like molecule. RPTKs transduce extracellular signals across the cell membrane, and play important roles in regulating cell proliferation, migration, and differentiation. PTK7 is organized as an extracellular portion having seven Ig-like domains, a single transmembrane region, and a cytoplasmic tyrosine kinase-like domain. PTK7 is considered a pseudokinase as it has several unusual residues in some of the highly conserved tyrosine kinase (TK) motifs; it is predicted to lack TK activity. PTK7 may function as a cell-adhesion molecule. PTK7 mRNA is expressed at high levels in placenta, melanocytes, liver, lung, pancreas, and kidney. PTK7 is overexpressed in several cancers, including melanoma and colon cancer lines.
Statistics
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PSSM-Id: 143237
View PSSM: cd05760
Aligned: 4 rows
Threshold Bit Score: 163.931
Threshold Setting Gi: 71895723
Created: 17-Aug-2007
Updated: 18-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 126310050  147 VTLRCHIDGHPRPTYQWFRDSNPLSDSQGNYSVSSKERNLTLRRASPEHSGVYSCCAHn-sFGHICSSQNITLSIADE 223
gi 116242736  146 VTLRCHIDGHPRPTYQWFRDGTPLSDGQSNHTVSSKERNLTLRPAGPEHSGLYSCCAHs-aFGQACSSQNFTLSIADE 222
gi 71895723   133 VVLRCHIDGHPRPTWQWFRDGAPLPDGRGTYSVSSKERTLTLRGAGPDDNGLYYCSARpraVGSVCSQDNFTLNIIDE 210
gi 153792686  135 VTLRCHIDGHPRPICHWFRDGTPLADDGQATSLSNKERTLTLHSAGADDSGEYYCCAHn-aAGSVCSNRNFTLSIIDE 211
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