Conserved Protein Domain Family
Ig_2

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cd05764: Ig_2 
Subgroup of the immunoglobulin (Ig) superfamily
Ig_2: subgroup of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of the Ig superfamily are components of immunoglobulin, neuroglia, cell surface glycoproteins, such as T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, such as butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond.
Statistics
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PSSM-Id: 143241
View PSSM: cd05764
Aligned: 9 rows
Threshold Bit Score: 142.239
Threshold Setting Gi: 62286924
Created: 19-Jul-2007
Updated: 18-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 118092246 301 GQRAALRCKARGDPEPAIHWISPegklisNATRSVVYDNGTLDILittVKDTGSFTCIASNPAGEATQTVDLHI 374
gi 47220103  313 GQTASLRCKAVGDPMPTVHWVAPddrlisNSSRATVYENGTLDITittSKDYGIFTCIAANAAGESTASIELSI 386
gi 148232200 303 GQRATLKCRAIGDPEPVIHWVSPddkimpNSSRTASYRNGTLDILvttIRDDGSYTCIAINAAGESTAQVDLKM 376
gi 41055379  303 GQGVTLKCKAMGDPDPAIHWRFPdgklvhNNSRTILYDNGTLDILittLKDSGAFNCVASNAAGIATAAVHVHM 376
gi 47210627  302 GQPASLKCKANGDPEPEVHWISPegrlisNTSRTLVFPNGSLDINttsVKDSGNFTCIASNAAGESTGRVELVV 375
gi 116242620 301 GQRATLRCKARGDPEPAIHWISPegklisNATRSLVYDNGTLDILittVKDTGAFTCIASNPAGEATQIVDLHI 374
gi 62286924  295 GQRATLRCRALGDPAPTMHWVGPddrlvgNSSRARAFPNGTLEIGvtgAGDAGGYTCIATNPAGEATARVELRV 368
gi 41016893  301 GQRATLRCKARGDPEPAIHWISPegklisNATRSLVYDNGTLDILittVKDTGAFTCIASNPAGEATQTVDLHI 374
gi 157676715 301 GQRVALKCKARGDPEPAIHWISPegklvsNTSRTLVYNNGTLDIListVKDTGSFTCISSNPAGEAHQTIELVI 374
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