1OW0,1I1A,1O0V,1F6A,1E4K,1HZH,1IGA,2QTJ,2QEJ,1R70


Conserved Protein Domain Family
IgC_CH3_IgAGD_CH4_IgAEM

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cd05768: IgC_CH3_IgAGD_CH4_IgAEM 
Click on image for an interactive view with Cn3D
CH4 domain (fourth constant Ig domain of the heavy chain) in immunoglobulin
IgC_CH3_IgAGD_CH4_IgAEM: Contains the third and fourth immunoglobulin constant domain (IgC) of alpha, delta, gamma and alpha, epsilon, and mu heavy chains, respectively. This domain is found on the Fc fragment. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. There are two types of light chains: kappa and lambda; each composed of a constant domain and a variable domain. There are five types of heavy chains: alpha, delta, epsilon, gamma and mu, all consisting of a variable domain (VH) and three (in alpha, delta and gamma) or four (in epsilon and mu) constant domains (CH1 to CH4). Ig molecules are modular proteins, in which the variable and constant domains have clear, conserved sequence patterns.
Statistics
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PSSM-Id: 319312
View PSSM: cd05768
Aligned: 31 rows
Threshold Bit Score: 127.041
Threshold Setting Gi: 103796
Created: 10-Sep-2007
Updated: 18-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 7 residues -Click on image for an interactive view with Cn3D
Feature 1:receptor binding site [polypeptide binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                            #                                          
1OW0_A      107 PEVHLLPPPSEELAlnelVTLTCLARGFSPKDVLVRWLqgsqe-lprekYLTWASRqepsq------gtttFAVTSILRV 179
1O0V_A      223 PEVYAFATPEWPGSrd-kRTLACLIQNFMPEDISVQWLhnevq-lpdarHSTTQPRktk---------gsgFFVFSRLEV 291
1F6A_B      118 PEVYAFATPEWPGSrd-kRTLACLIQNFMPEDISVQWLhnevq-lpdarHSTTQPRktk---------gsgFFVFSRLEV 186
gi 86318    392 PLIYPFAPHPEELSls-rVTLSCLVRGFRPRDIEIRWLrdhra-vpateFVTTAVLpeertangaggdgdtFFVYSKMSV 469
gi 104089   449 PTITLLPPSDDELRnd-fISLICMLKNFRPQDIYVFWKkdgvt-leedyYMTTTPVleee--------eegFISFSKLTI 518
gi 121055   232 PQVYVMGPPTEQLTeq-tVSLTCLTSGFLPNDIGVEWTsngh---ieknYKNTEPVmds---------dgsFFMYSKLNV 298
gi 21538829 362 PEAYVYSPHRDELNkd-tFRPSCMILDFYPESITVEWLqddkp-vpeadYASTLPQmhg----------stFFMYSKLDV 429
gi 62901523 234 PQVYILPPPAEQLSrk-dVSLTCLVVGFNPGDISVEWTsngh---teenYKDTAPVlds---------dgsYFIYSKLNM 300
gi 103796   449 PTVFILAPAEQRNLs--tVTLICYAKDFYPEQVLISWLvddqp--vetdVPTTEVVkte----------gtYSVFSQLTI 514
gi 127509   310 PKVYLLAPPESSGEs---VTLTCYVKDFYPKEVAVSWLvndkqveevvgYEQNTTAvidr--------nnlFSVYSQLII 378
                        90       100       110
                ....*....|....*....|....*....|...
Feature 1                    #        ## ## #    
1OW0_A      180 AAEDWKKGDTFSCMVGHE---ALPLAFTQKTID 209
1O0V_A      292 TRAEWEQKDEFICRAVHEa--ASPSQTVQRAVS 322
1F6A_B      187 TRAEWEQKDEFICRAVHEa--ASPSQTVQRAVS 217
gi 86318    470 ETAKWNGGTVFACMAVHE---ALPMRFSQRTLQ 499
gi 104089   519 ARSDWMRGATYSCIAAHN---TISQRDIKKNRG 548
gi 121055   299 ERSRWDSRAPFVCSVVHE---GLHNHHVEKSIS 328
gi 21538829 430 QKADWQRGRAYSCSVKHE---ALPQKFLQKTVS 459
gi 62901523 301 KTSKWEKTDSFSCNVRHE---GLKNYYLKKTIS 330
gi 103796   515 PASDWDSGVVYSCAVHHEtvmESVVKTIVRTTD 547
gi 127509   379 KTADWNSGSVFSCLVYHEs-iKDCVRHISRSIA 410

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