1FYT,1NFD,1KGC,2F53,2PYF,2AK4


Conserved Protein Domain Family
IgC_TCR_beta

?
cd05769: IgC_TCR_beta 
Click on image for an interactive view with Cn3D
T cell receptor (TCR) beta chain constant immunoglobulin domain
IgC_TCR_beta: Constant domain of the beta chain of alpha/beta T-cell antigen receptors (TCRs). TCRs mediate antigen recognition by T lymphocytes, and are composed of alpha and beta, or gamma and delta, polypeptide chains with variable (V) and constant (C) regions. This group includes the variable domain of the beta chain. Alpha/beta TCRs recognize antigen as peptide fragments presented by major histocompatibility complex (MHC) molecules. The antigen binding site is formed by the variable domains of the alpha and beta chains, located at the N-terminus of each chain. Alpha/beta TCRs recognize antigens differently from gamma/delta TCRs.
Statistics
?
PSSM-Id: 143246
View PSSM: cd05769
Aligned: 14 rows
Threshold Bit Score: 169.862
Threshold Setting Gi: 76779693
Created: 27-Jun-2007
Updated: 18-Aug-2016
Structure
?
Program:
Drawing:
Aligned Rows:
 
Conserved site includes 19 residues -Click on image for an interactive view with Cn3D
Feature 1:IgC heterodimer interface [polypeptide binding site]
Evidence:
  • Structure:1FYT_E; human T-cell receptor alpha/beta heterodimer interface between constant domains of alpha chain and beta chain, defined using 4.0 A contacts.
    View structure with Cn3D
  • Citation:PMID 9768757
  • Structure:1NFD_B; murine T-cell receptor alpha/beta heterodimer interface in IgC domains, defined using 4.0 A contacts
    View structure with Cn3D

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1            # ## #              # # # #                    ### ##  #           # # # ##
1FYT_E      118 FPPEVAVFEPSeaeis----htqkATLVCLATGFFPDHVELSWWVNGkevhsGVSTDPQPLKeqpalndsrYSLSSRLRV 193
1NFD_B      119 TPPKVSLFEPSkaeia----nkqkATLVCLARGFFPDHVELSWWVNGkevhsGVSTDPQAYKesn----ysYSLSSRLRV 190
2PYF_B      118 FPPEVAVFEPSeaeis----htqkATLVCLATGFYPDHVELSWWVNGkevhsGVCTDPQPLKeqpalndsrYALSSRLRV 193
gi 12034924  28 PPTKVEIFPPSakecrnqkdnkrkKTLVCVASGFYPDHVSVSWKKNGngvkdGVATDSAAKRtd-----ktYRITSRLRV 102
gi 58801250   6 KEPDVEILKPSeietg----ckkrVTLVCVAKDFYPDHVSIRWSLGSeeikdDVATDPYALQdnt---tklFSISSRLQI 78
gi 345582    18 TQPSVVLFDPSpqeik----kkgkATLVCLATNFYPDHVTLRWSVNDqvtttGVKTDDSPIRgsd----rmYSLSSRLRL 89
gi 212732   129 IEPDVVIFSPSkqeiq----ekkkATLVCLASGFFPDHLNLVWKVNGvkrteGVGTDEISTSng-----stYSLTSRLRI 199
gi 71795309   6 TGPTVTLLPPSsrecrnqkhqkrkKTIVCVASGFYPDHVSVSWEVNGqkvtdGVATDGAALRpeg----rfYRISSRLRV 81
gi 18077839   6 TNPTVKLLPPSpdelcyaqknrekVTLVCLATDFYPDHVSITWQVNGkekknNVATDHVAQQans---tslYSMSSRLRV 82
gi 12963328   7 REPTVVMFNPSeleir----ekrkATLVCLATNFYPGHVTISWSVNGqnrtkGVKTDDDAAHeet---trmYSMSSRLRV 79
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
Feature 1                                                      
1FYT_E      194 satfWQNPRNHFRCQVQFYGlsendew---tqdrakpVTQIVSAEAW 237
1NFD_B      191 satfWHNPRNHFRCQVQFHGlseedkw---pegspkpVTQNISAEAW 234
2PYF_B      194 satfWQDPRNHFRCQVQFYGlsendew---tqdrakpVTQIVSAEAW 237
gi 12034924 103 paddYNKLGNTFTCIVSFYDgekttp-----ynksidSIQGKSEGGM 144
gi 58801250  79 pk-kEFKPKHNYTCTVKYYYetdqskn----vsssiiGIEGDEYEPE 120
gi 345582    90 tkmdWMNPHNTFRCSVYFDPenitvs-----retkgrEGCGVTEDSF 131
gi 212732   200 saqeWFNPLNRFECIANFFKngtqqsi---qkiiygdTGCDIFKENY 243
gi 71795309  82 saedWFRPDSDFTCIISFFNgtstelysaslqgeaaaATEVMSRETY 128
gi 18077839  83 dqieWTNIKNNFTCIVTFYNghd------------ylMFQSNIKFSP 117
gi 12963328  80 streWFDVRNTFQCTVDMYYaterdiv----kyitggKECGLDKESY 122

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap