Conserved Protein Domain Family
IgC_Tapasin_R

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cd05771: IgC_Tapasin_R 
Tapasin-R immunoglobulin-like domain
IgC_Tapasin_R: Immunoglobulin-like domain on Tapasin-R. Tapasin is a V-C1 (variable-constant) immunoglobulin superfamily molecule present in the endoplasmic reticulum (ER), where it links MHC class I molecules to the transporter associated with antigen processing (TAP). Tapasin-R is a tapasin-related protein that contains similar structural motifs to Tapasin, with some marked differences, especially in the V domain, transmembrane and cytoplasmic regions. The majority of Tapasin-R is located within the ER; however, there may be some expression of Tapasin-R at the cell surface. Tapasin-R lacks an obvious ER retention signal.
Statistics
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PSSM-Id: 319313
View PSSM: cd05771
Aligned: 7 rows
Threshold Bit Score: 179.255
Threshold Setting Gi: 13124600
Created: 10-Sep-2007
Updated: 18-Aug-2016
Structure
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Aligned Rows:
 
dimer interface
Feature 1:dimer interface [polypeptide binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                 ####            # # # #                
gi 71897335  257 ASLTLQEATVNDEGTYICLVSTAQHQVQHNIQLlvsepPRVRVFPTeaslk-rdetITLTCNIAgYYPLDISVSWTqktp 335
gi 72004118  266 ASLTLARLKVSDEGTYICTVSTGLYQAQQVIQLhvtqpPHVSLSEEklvfr-delpQKLSCHCKnYYPLDVQMEWFsvss 344
gi 62901465  266 ASLTLPGLTIQDEGTYICQITTSLYRAQQIIQLniqasPKVRLSLAnea-----llPTLICDIAgYYPLDVVVTWTreel 340
gi 126336826  44 ASLTLPGLTVGDEGAYICQISSPTHQAQQILLLsvlepPRVRLSLArea-----gaPGLLCSISgYYPLDVAVSWSrqep 118
gi 47221573  458 ASVFLSNLKVRDEGSYICSVRLGPFHAQQIIRLhlfqpPQVLLSQEklvw--keepQTLSCHSAkYYPLDVQMEWLllpp 535
gi 139948506 252 ASFKLEPTRKHSEGTYVCSVMVPPLYGSHDIPLslseqPRVSLNVGstlsmvigqdQKLICEAEsYYPLDVDIEWYreph 331
gi 13124600  251 DEGTYICSVFLPHGHTQTVLQLHVFEPPKVTLS-----PKNLVVAPgt-------sAELRCHVSgFYPLDVTVTWQrrag 318
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
Feature 1                                   #### # ##                         ###
gi 71897335  336 edeve----ispsntrfSSHRQSQDGTYSINSYLSVnlata-qapaTYTCHVSHVALEAPISIS 394
gi 72004118  345 tdsep---svlsdqvslSSHRQHSDRTMSISSHLTLhpstf-ppgtTVTCRVTHPALDTPISLS 404
gi 62901465  341 ggsp-----aqvsgasfSSLRQSVAGTYSISSSLTAepgs---agaTYTCQVTHISLEEPLGAS 396
gi 126336826 119 gepa-----spasgasfSSHRQSSAGTYSLSSAIPAepgp---rgaTYRCHVTHVSLPEPVTLD 174
gi 47221573  536 sdtep---tvskdqgslSSHRQHADGSYSLASHLAVpstv--apgtQIICRVSHRALEAPLSVS 594
gi 139948506 332 ggspt---plflknvlySSHRIHQDGTYSLSAFFYLqpgle-dsgyKYTCRVSHKSLLTPVRKS 391
gi 13124600  319 gsgtsqsprdtvmdswtSGHRQAADGTYSRTAAARLiparpqhhgdIYSCVVTHTALAKPMRVS 382

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