2GK2,1L6Z


Conserved Protein Domain Family
Ig_CEACAM_D1

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cd05774: Ig_CEACAM_D1 
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First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
IG_CEACAM_D1: immunoglobulin (Ig)-like domain 1 in carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM) protein subfamily. The CEA family is a group of anchored or secreted glycoproteins, expressed by epithelial cells, leukocytes, endothelial cells and placenta. The CEA family is divided into the CEACAM and pregnancy-specific glycoprotein (PSG) subfamilies. This group represents the CEACAM subfamily. CEACAM1 has many important cellular functions, it is a cell adhesion molecule, and a signaling molecule that regulates the growth of tumor cells, it is an angiogenic factor, and is a receptor for bacterial and viral pathogens, including mouse hepatitis virus (MHV). In mice, four isoforms of CEACAM1 generated by alternative splicing have either two [D1, D4] or four [D1-D4] Ig-like domains on the cell surface. This family corresponds to the D1 Ig-like domain.
Statistics
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PSSM-Id: 319315
View PSSM: cd05774
Aligned: 26 rows
Threshold Bit Score: 125.846
Threshold Setting Gi: 149587184
Created: 24-Oct-2007
Updated: 18-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
2GK2_A         6 LTTESMPFNVAeGKEVLLLVHNLPqqLFGYSWYKGervdgnrqIVGYAIg--tQQATPGPansGRETIYPNASLLIQNVT 83
gi 62286470  394 LTIDPVPRHAAkGESVLLQVRNLPedLRMFIWFKSvytsqifkIAEYSRa--iNYVFRGPahsGRETVYTNGSLLLQDAT 471
gi 109461310 243 LSIEALPPSLPeGGNALLRVDNQAekPQVFFWYKGkrafeefkIAHYETa--sQTLKWGPkysGRERIYTNGSLLLQNVT 320
gi 149587186  78 LTVTPIPPNPLeGWDVTLSVSGAPggLLLYNWYRGaslsltqmILSYINa--tEIQTPGAahsGREAVHPNGSLLIQRVT 155
gi 119577694 308 TMIVPVPTKPTeGQDVTLTVQGYPkdLLVYAWYRGpasepnrlLSQLPS----GTWIAGPahtGREVGFPNCSLLVQKLN 383
gi 117306462  30 LTSKEMRFSAAeGAKVLLSVPDQEenLLSFSWYKGkdvnenftIAHYKKs--sDSLQLGKkvsGREEIYKDGSMMLRAIT 107
gi 119577694  11 ISITLEPAQPSeGDNVTLVVHGLSgeLLAYSWYAGptlsvsylVASYIVs--tGDETPGPahtGREAVRPDGSLDIQGIL 88
gi 6753400    35 LTIELVPPMVAeGGNSVLFVHEMPlnVQAFYWYKQrdstksyeVARYLTp--tNQSSKMPqhsDRKTVFYSGSLLIRNVT 112
gi 149587184 497 LRIVPVPQHPRvGEDITLSIWGLPglPKTYTWYRGaagk-phlILRYNTgvgvSNWLLGPahsGREAGTKNGSLLLRDVS 575
gi 194215533  35 VIVESFPPDAAaGDKVLLHVSHLPenLAAYIWYKAdrvdpkrqIISYIId--tSEIIPGPlysGRERIYDDGSLLLQDTT 112
                         90       100
                 ....*....|....*....|....*....
2GK2_A        84 QNDTGFYTLQVIksd--lvnEEATGQFHV 110
gi 62286470  472 EKDTGLYTLQIIyrn--fkiETAHVQVSV 498
gi 109461310 321 QEDTGIYTLESFdty--yrcEVAHVHFQV 347
gi 149587186 156 LNDSGSYLLQSInpq--fqtEIAFGFLRV 182
gi 119577694 384 LTDTGRYTLKTVt------vQGKTETLEV 406
gi 117306462 108 LEDTGFYTLQTFkah--gqqEVTHVHLQV 134
gi 119577694  89 PRHSGTYILQTFnrq--lqtEVGYGHVQV 115
gi 6753400   113 KADSGVYTLLTFnte--mesELTHVHLEV 139
gi 149587184 576 PQDSGRYIVHVVtlq---gkEEASITIDV 601
gi 194215533 113 QKDTGYYTIQVIkkdyliddIRTPVTEHK 141
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