1Z2K,2DRU,1QA9,1HNG


Conserved Protein Domain Family
Ig_CD2_like_N

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cd05775: Ig_CD2_like_N 
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N-terminal immunoglobulin (Ig)-like domain of T-cell surface antigen CD2 and similar domains
Ig_CD2_like_N: The N-terminal immunoglobulin (Ig)-like domain (or domain 1) of T-cell surface antigen CD2 and similar domains. CD2 is a T-cell specific surface glycoprotein and is critically important for mediating adhesion between T cells and antigen-presenting cells, or between cytolytic T cells and target cells. CD2 is located on chromosome 1 at 1p13 in humans and on chromosome 3 in mice. CD2 contains an extracellular domain with two or Ig-like domains, a single transmembrane segment, and a cytoplasmic region rich in proline and basic residues.
Statistics
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PSSM-Id: 319316
View PSSM: cd05775
Aligned: 14 rows
Threshold Bit Score: 82.7918
Threshold Setting Gi: 999826
Created: 24-Oct-2007
Updated: 18-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1Z2K_A        11 GVSGKPVQLRPSniq--tkdVSVQWKkteqgshrkIEILNWYn-----dGPSWSnvs----fsdIYGFDYgdFALSIKSA 79
2DRU_A        11 AITGSNVTLTILkhpl-asyQRLTWLht-----tnQKILEYFpn---gkKTVFEsvf-----kdRVDLDKtnGALRIYNV 76
1HNG_A         8 GALGHGINLNIPnfqmtddiDEVRWErg------sTLVAEFKrk----mKPFLKs--------gAFEILAn-GDLKIKNL 68
gi 74006297   36 AVSGSNVSLHISnlp---alSRVTWFyt-----anQKIVEWEsn---rtNFFNSkf------knRASLDEs-YALCIYKV 97
gi 149505864 112 GVVDGSVFLDPPevlp-qqyQDIVWDfn-----gsREILEWKknwdrkpKIYAHye-------nRVRLPQsnGSLWLTDL 178
gi 114050785  33 AIPGDNVTLHISnlp--knhKSLTWFy-------tTDQKIVEwe---fdEPMYFntk----fknRATLHPqsGALFIRNI 96
gi 148277578  26 AEMGGLITFTPSirg---kpVEILWKh--------NGDKVVEyd---nrEIEEFgsf-----kdRVVIDFetGQLTIKKL 86
gi 31872399   35 GALHKNVTLRASssq---tlQEIIWKk--------GKDKAVEwee--qyNVTAFppf-----vdRVHLNTgsGDLTIYNL 96
gi 540537     35 GAMNGNVTFYVSesq---pfTEIMWKk--------GKDKVVEwdqtsglEAFQSfk-------nRVHLDIvsGNLTITGL 96
gi 189534803   6 VTEGDSVTLHTGvte--lhkGELTWHfi-----adKSLIALInr---ayEAFSTmdgpngrfrdRLKLDNntGSLTIINI 75
                         90       100       110
                 ....*....|....*....|....*....|
1Z2K_A        80 KLQDSGHYLLEITntg-gkVCNKNFQLLIL 108
2DRU_A        77 SKEDRGDYYMRMLhe---tEDQWKITMEVY 103
1HNG_A        69 TRDDSGTYNVTVYstngtrILNKALDLRIL 98
gi 74006297   98 QKEDSSTYILRVLkds-gkEEDWAISLEVL 126
gi 149505864 179 RKEDSGPYNLKVTyvn-dvQERWTINLMVY 207
gi 114050785  97 QKEDSSTYLLRVLkdn-gdEKEWKISLMVL 125
gi 148277578  87 TSQDSGQYQSDITin--gkVQSSRHTLTVL 114
gi 31872399   97 AFEDEGDYQIESPs----vKNSSKFILRVV 122
gi 540537     97 TKLDEDVYEIESPs----vKKSSQFHLRVI 122
gi 189534803  76 RSEHAGVYEAQIFsd---nTSSKRFKVTVY 102
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