Conserved Protein Domain Family
DNA_polB_zeta_exo

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cd05778: DNA_polB_zeta_exo 
inactive DEDDy 3'-5' exonuclease domain of eukaryotic DNA polymerase zeta, a family-B DNA polymerase
The 3'-5' exonuclease domain of eukaryotic DNA polymerase zeta. DNA polymerase zeta is a family-B DNA polymerase which is distantly related to DNA polymerase delta. It plays a major role in translesion replication and the production of either spontaneous or induced mutations. In addition, DNA polymerase zeta also appears to be involved in somatic hypermutability in B lymphocytes, an important element for the production of high affinity antibodies in response to an antigen. The catalytic subunit contains both polymerase and 3'-5' exonuclease domains, but only exhibits polymerase activity. The DnaQ-like 3'-5' exonuclease domain contains three sequence motifs termed ExoI, ExoII and ExoIII, without the four conserved acidic residues that are crucial for metal binding and catalysis.
Statistics
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PSSM-Id: 99821
View PSSM: cd05778
Aligned: 31 rows
Threshold Bit Score: 165.486
Threshold Setting Gi: 86563326
Created: 1-Oct-2007
Updated: 17-Jan-2013
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 143811385 2294 IQNLTLISVELHa-RTRRDLEPDPEFDPICALFYCISSDTPLPDtek-----teLTGVIVIDKDktvfsqdiryq----- 2362
gi 118357165  860 HEDITMYTFEIFa-KSTPDMLPDPSSDPINFIVFDLENFKRTQGi--------iLVDEINCHEPidkvrky--------- 921
gi 145477337  653 QEDLVLMIFEIFs-YKDSKLLPDPEKDEISFIILHSYNVKSSKIm--------nKMLIIQNEENylkavngy-------- 715
gi 156089459  529 DNFESGIVIDVIteSEPNKVYPDPLVHSILAVVYTKRDHRLVQRfqelglpyadVQGAIIVDPLksgtkkqdrakltgfn 608
gi 156846635  662 HDVLTHFTLEVHt-DNIGSKFPDPKNDSVRLIAWKIDDETYPFQld------vaSEGFMIFCGPetevsnyhl------- 727
gi 50305361   612 SNRMTHFTMEIHv-NTREDKFPDPKYDAVRMIFWKVQDGTFPFDld------itQEGVLIFLDDvstens---------- 674
gi 6325090    664 HDSLTHLTLEIHa-NTRSDKIPDPAIDEVSMIIWCLEEETFPLDld------iaYEGIMIVHKAsedstfpt-------- 728
gi 45184725   624 GPQLLHLSMEIHv-DTRRNMLPNPRTDEIKMICWSIDGPQSVGTme-------lSTDGLLVSLNendaiykr-------- 687
gi 50294045   645 HDNLTHFSLEIHv-NTRGDLLPDPRKDEVSVIFWKVDSDTFPFSid------lqLEGIMYTNKLerenlie--------- 708
gi 50549261   525 SAALTVMSMEVHv-NTRKGLNPDPDLDPILFVVWHMLGGPSGVIi--------nAEDCPDFTNIi--------------- 580
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 143811385 2363 -------------tpllirsgitGLEVTYAADEKALFHEIANIIKRYDPDILLGYEIqMHSWGYLLQRAAALSidlc-rm 2428
gi 118357165  922 ----------------ygfndsmFKTIIVTKNEEELLLTFIKQIHIFNVDIITGWDIeKKSLFYFSHRCWQLGidvm-di 984
gi 145477337  716 ---------------fermnapvEYTIVLTQNEINLMKAFTLIVHLIDPDFISGYDLeTRSLYYVANRAEFIGydfl-te 779
gi 156089459  609 rfamvqrkninmdtieriinsqkYINVAYVQSERELIQEVENLFIKFDPNIIYGYDVaRSSIGYIQHRAAAIGvpdfler 688
gi 156846635  728 ---------------krieqaagSSAIGFYETEIDMFDALIDLILFFDPDILSGFEVqSASWGYLIDRYRFIQkesllee 792
gi 50305361   675 -----------------wktadpSVHITAYYDELEMIYALEDLVRFFDPDILSGYEIhSSSWGYLIDRCHKGHdydvede 737
gi 6325090    729 ----------------kiqhcinEIPVMFYESEFEMFEALTDLVLLLDPDILSGFEIhNFSWGYIIERCQKIHqfdivre 792
gi 45184725   688 ----------------iieeacgKTRVAFFTSEYELITEFAKLVLIIDPDILQDMNH-KSSWGYILARVELSHnidfgll 750
gi 50294045   709 ----------------tlesisgGVPIMEYEDEFSMFDALTDLILLFDPDLLSGYEIhNSSWGYIFERSLSVHkfniane 772
gi 50549261   581 -----------------------EAPSTVVKTECEMITHLQKMVENFDPDILTGFEVqASSWGYVQDRCKTMLypc---e 634
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 143811385 2429 iSRVPDDKienrfaaer------------------------------------------------------deygsytmS 2454
gi 118357165  985 lSRCPKNSfnilrafkladclieeqfqndsakgysqqsmsf-----dsnqsfklqnvamqsikqshrsakqtgffanfkL 1059
gi 145477337  780 iSRGQPTYdklieifdideilfnfgqpqpineklqkymdyrmqrptaskkqsfnqdaktksynskgklnqinsrrkklrF 859
gi 156089459  689 iSRVPPKHerqitdittimthq-------------------------------------------naklikgryksssiK 725
gi 156846635  793 lSRVSIDEasryidk----------------------------------------------------------wgsnrsS 814
gi 50305361   738 lSRVDYNQsskkkdr----------------------------------------------------------wgythaT 759
gi 6325090    793 lARVKCQIktklsdt----------------------------------------------------------wgyahsS 814
gi 45184725   751 iSRLSRDDrsglase----------------------------------------------------------wnyshsA 772
gi 50294045   773 iSRVNMGAqfklrds----------------------------------------------------------wgfkksS 794
gi 50549261   635 fGRVQHHKmsskidt----------------------------------------------------------wgarkaS 656
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 143811385 2455 EINIVGRITLNLWRIMRNEVaLTNYTFENVSFHVLhQRFPLFTFRVLSdwf---------------------dnKTDLYR 2513
gi 118357165 1060 NFEIAGRMIINTWRLVKHDYkLFCYELESVVNYVFqERIPIFSNWSLTqmy---------------------nhEDIKQR 1118
gi 145477337  860 ITFVVGRVLINVWRNVATDIkIIDYSIENVYFQMFkQKNALIHNQTLSq-------------------------WFKSET 914
gi 156089459  726 PVFCLGRLIFDLADVALRELnLANLTLENIVYNQFdYLMPVYSQYTLSkwlttsvqlnasndpsattesapkhgSYKPHA 805
gi 156846635  815 GVKVTGRHIINIWRAMRASTnFNQYTIENLCSKLLnKRLPHFSFSDLSkmw---------------------ngNDVTEI 873
gi 50305361   760 AFSITGRQMLNIWRPLRSSLnLLDYTLENIAFHVLhQRLPFYSYKTRTefy---------------------esMDETSK 818
gi 6325090    815 GIMITGRHMINIWRALRSDVnLTQYTIESAAFNILhKRLPHFSFESLTnmw--------------------nakKSTTEL 874
gi 45184725   773 GIKIAGRHMLNVWRKMRTEVnLAKYNIENVAYHLLhERLPKFTHETLSgfw--------------------rtkSDRTSI 832
gi 50294045   795 GISITGRYVLNIWRLLRKEIaVTQYSFENMVHLLLkIRLPKYSCSHLTslw--------------------snfKTGNEL 854
gi 50549261   657 GVKVVGRHVLNLWRMIRGEVsLLKYTLENVVFHVLhERIPFYTHDTLTem----------------------cvGSLSDR 714
                         330
                  ....*....|....*....
gi 143811385 2514 WKMVDHYVSRVRGNLQMLE 2532
gi 118357165 1119 VFVFEYMMKRLMKTKDIID 1137
gi 145477337  915 FLVFQYYAKRINMTFDILE 933
gi 156089459  806 YRAIRYMLFRNYAVLATMD 824
gi 156846635  874 KTVMSYWMTRVRCNMLLLK 892
gi 50305361   819 RCLLFYWITRLRVNFKLLE 837
gi 6325090    875 KTVLNYWLSRAQINIQLLR 893
gi 45184725   833 KIVINYCLERVRCNIRLLN 851
gi 50294045   855 KTFLNYYLTRVRLNIGILK 873
gi 50549261   715 KLLVEYKCTRSNYNLQLLS 733
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