Conserved Protein Domain Family
PGM2

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cd05799: PGM2 
This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and deoxyribose-1-phosphate to the corresponding 5-phosphopentoses. PGM2L1 is thought to catalyze the 1,3-bisphosphoglycerate-dependent synthesis of glucose 1,6-bisphosphate and other aldose-bisphosphates that serve as cofactors for several sugar phosphomutases and possibly also as regulators of glycolytic enzymes. PGM2 and PGM2L1 belong to the alpha-D-phosphohexomutase superfamily which includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Other members of this superfamily include phosphoglucosamine mutase (PNGM), phosphoacetylglucosamine mutase (PAGM), the bacterial phosphomannomutase ManB, the bacterial phosphoglucosamine mutase GlmM, and the bifunctional phosphomannomutase/phosphoglucomutase (PMM/PGM). Each of these enzymes has four domains with a centrally located active site formed by four loops, one from each domain. All four domains are included in this alignment model.
Statistics
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PSSM-Id: 100092
View PSSM: cd05799
Aligned: 118 rows
Threshold Bit Score: 402.27
Threshold Setting Gi: 47459037
Created: 1-Nov-2005
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
Feature 1:active site [active site]
Evidence:
  • Comment:Based on the structures of Candida albicans AGM1 (N-Acetylglucosamine-phosphate mutase) and Pseudomonas aeruginosa PMM/PGM bound to their substrates and divalent metal ions.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1            # #  #                                                                      
gi 14603253   54 RMEFGTAGLRAAMGPGisRMNDLTIIQTTQGFCRYLekqfsdlkqkGIVISFDARAHpssggsSRRFARLAATTFISQGI 133
gi 14248265   72 KLTFGTAGIRGKFGLGegRLNKFTIEKLALGLARYLnaqt---nspTIVIHYDIRHL------STEFAQIIANVLANHQI 142
gi 73663046   33 VLSFGTAGIRSTFGLGpaRLNAFTVRKVALGLAQYLnhnv---ddaSVVIHFDTRFL------SKAFSQEMASVLANNGI 103
gi 26553561   53 KLSFGTAGIRATMGPGtnQINVFTYQQMSEGVARWLlnkk---snpTVIVAHDNRMN------ADYYAMVIAKTLTSFGI 123
gi 31544786   54 PLGFGTAGIRQKMGPGyrYLNDFTYAQMAFGYGRFLidkf--gfspRCVIAHDNRKN------GVHFAKIITDVLTSMGI 125
gi 1352196    39 PLSFGTAGIRAKMAPGtqFLNKITYYQMATGYGKFLknkfs-nqniSVIVAHDNRNN------GIDFSIDVTNILTSLEL 111
gi 12044903   41 KPLFGTAGVRNKMAPGyhGMNVFSYAYLTQGYVKYIesinepkrqlRFLVARDTRKN------GGLFLETVCDVITSMGH 114
gi 6899534    42 RFKFGTSGVRCIYEEGtrYLNAITYTQLTLGFIEYLetkk--nfnkIIVIGRDNRFG------SRENLKLVAEIFSSFDY 113
gi 148377728   3 KLEFGTAGIRGKIGSGveNLNIAHVRRIMHGYAKYLlnkya-kqeiKIVIGRDNRRK------SYSFALCSAQILDSYGI 75
gi 47459098    3 ELEFGTAGLRGILGKTkeHLNIFHVARVIEGFAKYLksetfnwknkIVIIGRDNRRK------SREFSRLAASILAFHKI 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                         ###       #                                    
gi 14603253  134 PVYLFSd--ITPTPFVPFTVSHLklCAGIMITASHNPKQDNGYKVYWdnGAQIISPHDKGISQAIEEnlepwpqaw--dd 209
gi 14248265  143 TVYLPDt--YKTTPELSFAVRNLntTAGIMITASHNPKDYNGIKVYGsdGAQLSTDASELASRYIEEvgdplqid---ip 217
gi 73663046  104 TAIISDn--YKSTPELSFAVRHLqvNAGIMITASHNPKNYNGIKIYNekGGQLLPEASEQLSEYINSietplniek-gdf 180
gi 26553561  124 KVFLYKenqIKATPIISYSVRETgvDAAIIATASHNPKNYLGFKVYNhtGGQILDSEANEIVSSMPEcqtiidn------ 197
gi 31544786  126 EVYLFDnnkISSTPILSYAIPRYnaDGGINVTASHNRKTDNGFKTYNekGAQLLNQDAQKIIDFMPKsceilnl------ 199
gi 1352196   112 EFICLKiinLLLRQLFSYAIRKLnaQGAVIVTASHNPKEDNGFKIYNetGAQVLPDDGLKVVELMPNvfemidl------ 185
gi 12044903  115 LAYVFDdnqPVSTPLVSHVIFKYgfSGGINITASHNPKDDNGFKVYDhtGAQLLDTQTNQLLSDLPCvtsmldl------ 188
gi 6899534   114 TVYINEdygMLSTPITSFLINQLqaGAGIMITASHNPKNYNGFKVYNanGAQPLVDDTNLIESLMPSytealdf------ 187
gi 148377728  76 KVYFSKn--ICPTPFVSYSIMHYkaHGGINITASHNPKEYNGIKLYNesAFQMLPEEIQEVSSYFDDyekylepyktvks 153
gi 47459098   77 NVLISRe--IIATPIISYATKYHkaLGAINITASHNPKEYNGIKLYDknGSQILPDVVDKIKSNFLNyedytkkqalnqf 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
gi 14603253  210 slidssPLLHNPSAS-INNDYFEDLKKYCfhrsvn---retkvKFVHTSVHGVGHSFVQSAFKAfdlv-------ppeaV 278
gi 14248265  218 iskqntSYIKPFPKS-VTDDYMKHIQNMIgyip------ksdlQVVFTSLHGTSVPIVPELLKSlnfn-------qfnlV 283
gi 73663046  181 nafvenGKIKYMSNE-VTESYKKEVKSLVgsid------ahdaKVILTSLHGTSLPLVSDILTEldyh-------nfviE 246
gi 26553561  198 vytpnmDLISYFDDT-ITESYFEASYRCLintniy---rqknfPVILTTHHGTASYDLPYLLKSigye-------niilA 266
gi 31544786  200 eyqpndRLVKFIPDE-IYDRYFADIYRDLyttdhk---evkdfKVIFTGQHGAASYWLPEMLRRfnyn--------vipV 267
gi 1352196   186 kvanddSLITYLNED-IFRQYYEDCKQALiktnin---eskefSIVFSGQHGTACKRLPEFLKLlgyk-------niilV 254
gi 12044903  189 elqpnpKFVHTLDNEkVYKNYFRELKKVLvinnn----nfkdiKVVFSGLNGTSVCLMQRFLKYlgys-------niisV 257
gi 6899534   188 nfefkqDNIRFLTKE-QIQSYFDAVKAQLintdpn---ikkpfKIVFSGHHGTTTKDMIPFLESlgyd--------mvsV 255
gi 148377728 154 ikksefNNLEFISEK-VKDKYLNSVAQIAnnldksvnlnpeniKVVYSPLHGTGSKFVPKLFKKlfsesaydinesifyV 232
gi 47459098  155 ifsiknKYINYIPKQ-TLQSYEEKVLKVGgsqkn-----lsniNLSFSPQHGTGAKIVKSIFKKlnvn--------affE 220
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                   # # ##                               
gi 14603253  279 PEQKDPDPEFPTVKYPNPEEgKGVLTLSFALadktkaRIVLANDPDADRLAVAEkqdsgeWRVFSGNELGALLGWWlfts 358
gi 14248265  284 DAQCKPDPNFSSVQSANPED-HRAFDQAVELankshaDLLISTDPDADRLGIAErdahghITYFNGNQIGALLLNYriqq 362
gi 73663046  247 KEQSEPNGNFPTVAIANPED-EAAFTLGKQLadktdaQLIIATDPDADRLGFIErygdndFRYFNGNEIGLLLMKLrfqd 325
gi 26553561  267 AQQCVPDPNFTYSANFNPED-KASFDLSLKYaekyraNIMLGVDPDSDRLAVVVrhk-nkWHYLTGNQMGIIFTHYvltn 344
gi 31544786  268 KEQCKYDENFTYTKSPNPEA-RESWDLALKYaqhygaDIMLATDPDADRLAVAVkhn-neFRYFNGNEMGIIFAYYilky 345
gi 1352196   255 EEQCIFDGNFSNTPTPNPEN-RAAWDLSIEYadknnaNVIIQVDPDADRFALGVryk-nsWRFLSGNQMGIIYTDYilkn 332
gi 12044903  258 EEQNWFDENFENAPNLNPEY-KDTWILAQKYakknnaKLIIMADPDADRFAIAElnn-nqWHYFSGNETGAITAYYklnh 335
gi 6899534   256 SEQNFEDPNFNDDPSSNPEE-QCSFDLSVEYadntnaEIMIASDPDGDRMAIAVrhe-nyWKFLTGNQTGVLIAHYlleh 333
gi 148377728 233 KEHMKIDANFKYVQYPNPEK-HSAYELLIKLgkqkdaDILLMSDPDSDRVGLAVkhs-deYRILNGNETAIIVFKFlldl 310
gi 47459098  221 EAQMKNDPDFTHTKSPNPED-KSSYENVIKLglihksDAVLITDPDADRVGIGIlrn-neYILLNGNETATLIFNYliei 298
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                            #                    ###                       # # #        
gi 14603253  359 wkeknqdrsalkdtYMLSSTVSSKILRAIALKEgFHFEETLTGFKWMGNRakqli--dqgktVLFAFEEAIGYMCCpf-v 435
gi 14248265  363 ts-------qlrhrLMIQSIVSSELTKSLARYNnVKYKEVLTGFKFIAQEirqld---dhqnMIFAFEESYGFLSEpf-v 431
gi 73663046  326 lt------edstpqYMIKSIVTSELAERLATSLnVEVNDVLTGFKFISDLiehkqk-dddkqLLLAFEESHGYLAQpi-s 397
gi 26553561  345 kk-------fdktpFVVSTFVSTNYIDRIAEKYnAKVFRTPTGFKWVGNEmnkhi---dkmdFVVGFEEAIGSLNSdi-g 413
gi 31544786  346 kq-------ltkrpYIVSSYVSTNLIDRIIAKYnGVVYRVGTGFKWIGNKaidhk---dqedFILGFEEAIGALPTti-g 414
gi 1352196   333 kt-------ftkkpYIVSSYVSTNLIDRIIKEYhGEVYRVGTGFKWVGDKinkik---dseeFVVGFEEAVGALNSti-n 401
gi 12044903  336 k--------vfkspYIVSTFVSTYLVNKIAKRYgAFVHRTNVGFKYIGQAinels---qtneLVVGFEEAIGLITSdkln 404
gi 6899534   334 kk-------ftkptYIISTFISTRYPELFAKNFdCDVLYVDVGFKNHGNLianrk---kthnLVVGFEEAIGSLPSdi-n 402
gi 148377728 311 vkst---ikqpnnhYIVYSFVSTNIPEILALSEgIKSVVVPTGFKWIGKIinefs--negkkFMFAFEESYGSLIDenls 385
gi 47459098  299 ne------nklqdkYLIYSFVSSSLPKKMAIENnIKWYEVATGFKYIGNLieqiknesktskLLFAFEESYGSLINdsla 372
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
gi 14603253  436 LDKDGVSAAVISAELASFlat-knlSLSQQLKAIYVEYGYHITKASyfic-----hdqETIKKLFENLRNYDgknnypka 509
gi 14248265  432 RDKDAVQIVPLIIKYASElkl-ygkTLKDELEQIYQTVGRHEDTLFshtle--glegkKKIESIMTHFRSNPpqeiqglk 508
gi 73663046  398 RDKDAIQMVPLLVKYKNLldk-ngiTFKETIEDIYENIGYFKDRTLaptfe--gkagvKKIESIMSQFRNEQvfsicgmd 474
gi 26553561  414 RDKDGFQAAALALEVYTMlyd-qekTLVDYLDEIFEEFGAWTGETVsykie--slnwkEEMQEKMDKFANVKnkdilgle 490
gi 31544786  415 SDKDSFQTAALALEIYNEclkrkitMVDFLEREIYPQFGFIHNDTIttlin--dldwkKKANDWMERLKRYDqpyindrk 492
gi 1352196   402 RDKDAYQAAALALEIYNEclknninIIDHLEKNIYGKYGIIHNDTIsftfv--ennwkELVKKSLDKILKYSektignrt 479
gi 12044903  405 REKDAYQAAALLLEIARHcke-qniTLLDFYKRILSEFGEYFNLTIshpfkatatdwkEEIKALFNQLINANltevagfk 483
gi 6899534   403 NDKDSYQTASILLEMINYyyeqkldLFTVLKKEIFAKYGNWYSKTTqfvid--gdnwkQKALIILNNLRNFEfktvtqyt 480
gi 148377728 386 RDKDALQSIAILTKMASYykk-qnkTLIDILNEVYETVGYVASENIeievd--estdlALLQEKFKNLNFENkiiedfnl 462
gi 47459098  373 YDKDAIQSCVILAKMISFykk-kskTLLDVLEDIYKKYGYIKSESFsinldeknplhlENIQSKFINLKFNEdfkienfi 451
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                         # ###    #                     
gi 14603253  510 cgkfeisairdlttgyddsqpdkkavlptskssQMITFTFAn-gGVATMRTSGTEPKIKYYAELcapp-------gnsdP 581
gi 14248265  509 vkaiedylts-----evyhldkdttsqinssksNVIRVLFDe--GFIALRPSGTEPKIKLYVSLkc-----------pdF 570
gi 73663046  475 vlkiedyhvg-----evrdmitghtekltlpktNLIRFIFEn--GFIALRPSGTEPKIKLYFSLe--------------V 533
gi 26553561  491 i-----------------------kgirwnepaQALEWYLEn-dMWVKFRLSGTEPKFKIYYEIyg-----------etK 535
gi 31544786  493 i-----------------------vsikwnqagDCLDWILEd-dSWIRFRLSGTEPKFKFYYNLyg-----------nsL 537
gi 1352196   480 i-----------------------tsikynevgGCYDWILDg-dSWLRFRMSGTEPKFKVYYNLyg-----------enL 524
gi 12044903  484 v-----------------------vkvhldkqtNILEFGFEn--GWVKFRFSGTEPKLKFYFDLtn-----------gtR 527
gi 6899534   481 i-----------------------hniifheqgSYLEWKLDe-ySTIKFRLSGTEPKFKVYIDLydfskdqkrdfyqelK 536
gi 148377728 463 --------------------------kssfmksNMIQIKFKndnSWLALRPSGTEPKIKFYVFAfd-----------ktI 505
gi 47459098  452 k------------------------gkeniapsNMIRISFQn-lNWIALRPSGTEAKIKFYLYVvd-----------kdK 495
                        570
                 ....*....|..
Feature 1                    
gi 14603253  582 EQLKKELNELVS 593
gi 14248265  571 DDVAQKINAMIF 582
gi 73663046  534 ENIDEITQQFEA 545
gi 26553561  536 EICDQILKALKD 547
gi 31544786  538 KQLKEEANQITK 549
gi 1352196   525 NALSQEAKTIND 536
gi 12044903  528 EALEKQAKKIYK 539
gi 6899534   537 IKAEDILDFLKN 548
gi 148377728 506 DLAQQKLNKFKE 517
gi 47459098  496 ILVEKNWNILKE 507

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