Conserved Protein Domain Family
PGM_like4

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cd05803: PGM_like4 
This PGM-like (phosphoglucomutase-like) domain is located C-terminal to a mannose-1-phosphate guanyltransferase domain in a protein of unknown function that is found in both prokaryotes and eukaryotes. This domain belongs to the alpha-D-phosphohexomutase superfamily which includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this superfamily include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine mutase (PNGM), phosphoacetylglucosamine mutase (PAGM), the bacterial phosphomannomutase ManB, the bacterial phosphoglucosamine mutase GlmM, and the bifunctional phosphomannomutase/phosphoglucomutase (PMM/PGM). Each of these enzymes has four domains with a centrally located active site formed by four loops, one from each domain. All four domains are included in this alignment model.
Statistics
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PSSM-Id: 100096
View PSSM: cd05803
Aligned: 12 rows
Threshold Bit Score: 625.872
Threshold Setting Gi: 28261217
Created: 23-May-2007
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
Feature 1:active site [active site]
Evidence:
  • Comment:Based on the structures of Candida albicans AGM1 (N-Acetylglucosamine-phosphate mutase) and Pseudomonas aeruginosa PMM/PGM bound to their substrates and divalent metal ions.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1          # #  #                                                                        
gi 66812932    5 IRSISGVRGVVGadq--swTPTLVANHIIAFTQLlesshy-----nqnqkKIVVGRDSRVSGPWFEMITNGSLISRGYQV 77
gi 32476100   38 IISVSGLRGILGet----lTPEVAVRFAAAFSASmp------------egKIVVGRDGRTTGPMLRSAIVSALTASGRDV 101
gi 87310711   16 IISVSGLRGVVGes----lTPSVAVRYIAAFAEQvs------------pgPILIARDGRPSGKPLAHLIAGTLNFCGRDV 79
gi 24216499   14 MVSVSGIRGIIPtg----lSPEVIFNSLRAFGTWie------------gsKIVIGRDSRPSGSYLENIALGLMQAMGKEV 77
gi 28261217    5 IATFSGLRWIHDe-----qSFGRIMCYVTAFAKAlpqmvdnc-sttrskkLVYVGRDGRNTGDEYPKYIIAALLLEGFNV 78
gi 123455957   7 MLTISGIRGVVGgs----lTPEVVSKYVSGFAGLqltk--------gkgkQVILGYDTRPAVSWIKQVTIGALMACGIDV 74
gi 67468086    6 MVTLSGIRGIAQks----lSEAVIIKYVKAFVTIqfeeh-------tknsLFILGRDSRVSGPWAEKIVIKALEECGCKV 74
gi 83816762   87 IASISGIRGIVGqg----lDPSVLVRYAGAFGTWcreran----aadrpsRVVVGRDARPSGDACAQIVIGTLRGMGCDV 158
gi 21673099    4 MISVSGIRGVVGks----lTPENLTAFTMAFATWirrrkqalnpgslakpIIVIGRDSRPTGAVITGLVSNALSLCGCDV 79
gi 34540827    4 IKSISGIRGTIGgmadeglNPISIAQFTAAYAHFikklt------ktkrpCIVVGRDARPSGLMVKNVVFGTLMGMGCDV 77
gi 149176180   5 ILSISGLRGVVGng----lTPDYLTRFAAAVGTIan------------qgTVVLSRDGRGSGEMVRHAVIGGLLATGCRV 68
gi 150383824   8 KFSESGVRGIVGeg----lTPRLVTELGAAFGFYqg------------ggRIVVGRDTRATGAMFEDALVAGLLSAGCQV 71
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                    ###       #                                         
gi 66812932   78 IHIDIASTPTVQYMVEKTKSSGGIVITSSHNPIEWNGLKFIGPDGLFIAPKECEILFSMADKpeefkf------------ 145
gi 32476100  102 IDADVAATPTIGVLVRELGAVGAIAISASHNPPEYNGIKLFGGDGRVLDAESGAKIRDAYFAgtnqwa------------ 169
gi 87310711   80 IQADIAATPTVGVLTRQYQCGGAVQISASHNPPQYNGIKLMGADGRVIPADQGESVLTAYHAnsaswv------------ 147
gi 24216499   78 LQLGIVPTPTVKAVVNLSKAGGGIMISASHNPIIWNAFKFIGPGGFFTNASDLEQILETVRNqsykpi------------ 145
gi 28261217   79 KYLDIVPTPTVQQLVRNSQCAGGVIATASHNPPKWNGLKFVGPSSIFLTPDECTRVYSCVTEdmlqkeyhsfmtkhphtv 158
gi 123455957  75 VDIGIVPTPTVQLMVQQFKACGGIVITASHNPQQWCGLKFVEFTGIFLDQFNCDEMFSCKYSkfat-------------- 140
gi 67468086   75 LNCGIVPTPTVQVMVQQHQASGGIIITSSHNPKPWNGLKFVDSDGLFIVPKKCAKVFTLADEgtfi-------------- 140
gi 83816762  159 VDLGMASTPTVEMAVLQEQAAGGIVMSASHNPEEWNALKLLNETGEFLTPAQGEAVIERAEAgeaap------------- 225
gi 21673099   80 IDVGMTTTPTVEIATAGEGADGGLIVTASHNPVEWNALKMLDEKGEFLTASDVGELLEIAEKkafdfa------------ 147
gi 34540827   78 VDIDLATTPTTEMAVTGCGADGGIIITASHNPVQWNALKLLGPSGEFLNDAEGKEILRIAEAgeaefa------------ 145
gi 149176180  69 IDAGIATTPTCGVLVTHLKAAGGIQITASHNPIPWNGLKPFSSEGSVYNQEQGEKLLSVLNNetfnyv------------ 136
gi 150383824  72 VKLGVVPTPTIQFTVTRTGASGAVAITASHNPAQWNALKFIGSRGTFLDRGEASELFDLYSQgslpcr------------ 139
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
gi 66812932  146 ---------------sgydqlGKIEKCVDANQQHVGAILSLAFLdiski-rerrFKVCLDSVNGAGGPIMSYLLTQLNce 209
gi 32476100  170 ----------------tydkiGQVDSIEDPHAAHLEKVLATVDVdaik---akqFRVLIDSNHGAGGLLGVRLLEALGct 230
gi 87310711  148 ----------------aheqlGSLTNCEDTLSQHLTKVLAIVDVarik---qrkFRVLLDSNEGAGSLLGRRLLETLGce 208
gi 24216499  146 ----------------qykpsSKIVFGTEWSEKHIESVLKRVDVnsir---kkkYKVLIDSVNGAGSYLVPELLKKLGck 206
gi 28261217  159 lvqeiadsiqnkktythnkakMEYVGSDDAIAEHIKHVLAQTPLvnaasiresnFSIGFSGCNASGAMYIVSLCEHLGvs 238
gi 123455957 141 -----------------wdklGTLTNYPNAIQDHINNIFGQKFIdveki-kkqhFKVAVDTINGAGSLAIPVILRQLGce 202
gi 67468086  141 -----------------hqegGITQSLSTAIDEHLNKILSLPYIdveai-kkqhFKVAVDSVCGAGGPIMTELLTRLGce 202
gi 83816762  226 ----------------athaaLGGYRSRNALPEHIDEILALDLIdpegi-aaqnLSVVVDGVNSVGGVALPRLLHRLGva 288
gi 21673099  148 ----------------rwdgiGTVTANGSWDAAHIDKILKLSCLdldlv-ksmnFRVLIDAVEGAGSYIVPELCRKLGit 210
gi 34540827  146 ----------------pvekmGRLADTLDYTPAHIKAVLALPSVdvaai-raakFKVAIDCVNSVGGIAIPALLTALGve 208
gi 149176180 137 ----------------swdqlGSVETLEDAAAPHMDRVFKLIDReqik---qrqFKVVLDCNHGSGAVSTPRFLESLGce 197
gi 150383824 140 ----------------gekdfREVRFMEGAFKEHMARIFSVVDAelir---errFRVAVDCANGVGALCSAGFLEKLGc- 199
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                     # # ##                             
gi 66812932  210 ---vIGINLETTGLFAHTPEPVPSNLGQLCEMVvky-kaDFGIAVDPDVDRCVFIDehGKPLGEEYTLAMAVElvlgd-c 284
gi 32476100  231 ---vEAMGHEPTGKFAHTPEPTAENLQGISADVtgr-kcVVGFCQDPDADRLALIDetGRYIGEECTLALCVRqamet-g 305
gi 87310711  209 ---fEILGNNASGNFLHTPEPTAANLQEVCAKIvas-gaDIGFCQDPDADRLAIIDaaGRYIGEEYTVALCLDhvla--- 281
gi 24216499  207 ---pILLHCVPDGTFPRPPEPTPEALKQTSRKMkss-gaDIGFALDPDADRLVVLTpkKGAISEEYTLPLSFLsltleki 282
gi 28261217  239 ---lKVPYMMEPGPLPLQPEPIPENLVQFGQAIkdqgdvHVGFAVDPDADRLVILTe-TGVVGEDYTLALCVDyalslqp 314
gi 123455957 203 ---vTELNTEPTGLFAHTPEPIPENLTQLCDAVkg---hDIGIAVDPDSDRCVLIGedGIPLVEEYTLALAVNyalky-g 275
gi 67468086  203 ---iIPLNIKPTGDFPHIPEPLPENLTDLCHIVkes-kaDLGIAVDPDVDRCVLIGgdGNPIGEEYTLVCAVYfvlky-c 277
gi 83816762  289 eenvHCLHCEPTGAFAHPAEPRPDHLTELTAAVpeh-gaDLGLAVDPDADRLALVDdrGRFMLEELTQVLAADflwr--- 364
gi 21673099  211 --eiKTLACEGTGIFPRNPEPIEQNLRQTMAILase-scEFGIIVDPDVDRLALVCedGTLFGEEYTLIACADfylk--- 284
gi 34540827  209 --hvFPLYCTPDGQFPHNPEPLPQNLTEICKVVkek-kaNVGFVVDPDVDRLAIVDenGEFFGEEYTLVAIADyllg--l 283
gi 149176180 198 ---vIVLGGTADGHFAHTPEPLKENLTGLSEAVvka-gaDAGFAQDPDADRLAIVDdtGRYIGEELTLALAADyvla--- 270
gi 150383824 200 ---eVFAVNTGIDGFRRPPEPLPENLGELAELVkre-hcDVGFGQDPDGDRLTVVTdrGEALNPHYTVALAVEqvle--g 273
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                  #                         ###                  # # #                  
gi 66812932  285 grrGNVCKNLSSSRAIDDIck-----kYESQVICAPVGEIQVAKKMqq--vnAVIGGEGNGGVMLPdi-hIGRDAPVAAT 356
gi 32476100  306 rrsGPIVINGATSSMSTLIak-----qHGVETFRSAVGEANVCDLMia--kkAAYGGEGNGGPIDPav-gYVRDSFVGMA 377
gi 87310711  282 srqGPVVINCATSLMNEAIak-----kHGSPIFRSSVGEANVTDMMia--kqAIFGGEGNGGPIDPrv-gYIRDSFVGMA 353
gi 24216499  283 pkkANIVVNLSTSFINEFVar-----qNGVPVFRSKVGEANVVSEMlr--qkSIFGGEGNGGVIDPtiasFGRDSLSGIA 355
gi 28261217  315 pgeYHIVTNISTSLVVADAcrkheergVKGVLHYTAVGEVNVALKMlelgdrCLVGGEGNGGVMLPsa-hIGRDSIVAIV 393
gi 123455957 276 gvkTPVCRNISTSRAVDDIcr-----qHGVTCYGTPIGEVNVAMRMve--vgSEIGGEGNGGVMLTsc-hIGRDALVATA 347
gi 67468086  278 gkkGNVCKNLSSSRATSKVce-----kFGSKCYNTPVGEIQVGIGMkq--lnAVIGGEGNGGVMLPdv-hIGRDAMVAST 349
gi 83816762  365 hreGPFVTNLSSSRAIDDVaa-----rHGQPVYRSAVGEINVVQRMke--vdAVLGGEGNGGVILPdl-hYGRDALAGTA 436
gi 21673099  285 hhkGPVVNNLSSSHALFDIar-----kHEVECFSAKVGEANVIEVMke--keAVIGGEGNGGIILPel-hYGRDALAGIA 356
gi 34540827  284 nggGNTVSNLSSTRALRDVta-----rHGGKYEAAAVGEVNVVTKMke--igALIGGEGNGGVILPel-hYGRDALVGIA 355
gi 149176180 271 rtpGPVVVNGSTSRVTADIaa-----kYNCPFFRSYVGEAHVCAKMkq--esAILGGEGNGGVIDPkv-gYVRDSYVSMA 342
gi 150383824 274 gdpGPVVVNMQTSRLLEYIcg-----sFDCKLLSSKVGEINVVEKMie--ndSEIGGEGNCGGVIYrrvhPGRDSFTGMA 346
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                        
gi 66812932  357 LALQLMAnrys--qapSISKLKETLPTYEIVK-LKAGI----EGLDPDSILAEYTSqfinkpg-vvinqeDGLKIDSq-- 426
gi 32476100  378 QTLALLArt-----gkPLSELADELPQLSIHK-SKAGV----SAVQLPAVFDKLEAkftda----eatrgDGMRLQWs-- 441
gi 87310711  354 LVLDAMAas-----ssTVAELADSIPRFEILK-TTMPL----DREQLAGSLDRLTAyfsda----rasrlDGLRFAWd-- 417
gi 24216499  356 HILNVMAat-----gkKIDSIVEELPAIYMQK-TSFKI----AGKNLQDIYSKFRGefstf----seetiDGLRLTSe-- 419
gi 28261217  394 LVLSWLAkmrklhgerPISELVAERFQKYYIKkNKYTI----APEKRAKLDKKLQAlaqease-ydvdtvDGVKFTSvss 468
gi 123455957 348 MVLQLFAaereqnpniTISQIKGALPQWRISK-KKIPMk--nTTNVPELIEQWKEKmmkqyartialdekDGLRVDNr-- 422
gi 67468086  350 LTLMLMTke-----qkPLKEIVSQLPQFRIYK-TKVDTnkvnVDKAFELVKKTYQQeei--------derDGLYVSTk-- 413
gi 83816762  437 FVLQHLAds-----grSLGALHDDLPHYAMAK-DNLPL----PDVAPDRLLAALAEkysdt----nqstlDGLKINFd-- 500
gi 21673099  357 LFIQAFAgwks-atggTLSEFRKTFPDYFMSK-KKVELtt-lSKESLDRIFDTVAAnhpda----ecnrlDGLKLDFe-- 427
gi 34540827  356 LFLTHMAkr-----keAVSRIRAEYPAYFMSK-QRVDTp---AGTDTQRLLQTMFErykne----qistvDGVKIDFp-- 420
gi 149176180 343 YVLAGLAas-----gqKLSSWSDSLPQYSIVK-NKITC----PREKVEDACKALEShfdsa----tasrgDGLRLDWd-- 406
gi 150383824 347 LILERLAms-----dgPLSEIIDGYPPMCNLS-ARFTVp---PIPAREVLASLSRKyekyh-----pltfDGLRFDLe-- 410
                        490       500       510
                 ....*....|....*....|....*....|....*
Feature 1              # ###    #                   
gi 66812932  427 dWWVHLRKSNTEHIIRVIAEAKSVKEATDIATKFI 461
gi 32476100  442 dRWLLVRGSNTEPIVRMIAEAPTADEAASLCDQAS 476
gi 87310711  418 dAWLLIRGSNTEPIVRIIAESPASDRSAALCEAAA 452
gi 24216499  420 dSWIHIRPSNTEPIIRIIGEARTKKDLNSLLDRAG 454
gi 28261217  469 rKWVHMRFSNTEPIIRIISEAPSEDEAVELIKNYE 503
gi 123455957 423 dWWVHVRKSNTEPIVRVIGEAHTQDEADDLCNKVY 457
gi 67468086  414 dFWVHLRRSNTEPIVRVIAEAESLEKAKETAEKVM 448
gi 83816762  501 eSWVHMRPSNTEPILRVYTEAPTQDDAQALADRFC 535
gi 21673099  428 nGWVHLRPSNTEPIVRIYTEASTQAEADALAARFI 462
gi 34540827  421 dSWVHMRRSNTEPIVRIYTEARTEKEAQDLADRFR 455
gi 149176180 407 dRWVQVRASNTEPIIRVIAEAPESEAAEALCESAM 441
gi 150383824 411 eGRILVRSSNTEPIMRLNVEADDRPTAEALLNRFT 445

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