Conserved Protein Domain Family
StaR_like

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cd05804: StaR_like 
StaR_like; a well-conserved protein found in bacteria, plants, and animals. A family member from Streptomyces toyocaensis, StaR is part of a gene cluster involved in the biosynthesis of glycopeptide antibiotics (GPAs), specifically A47934. It has been speculated that StaR could be a flavoprotein hydroxylating a tyrosine sidechain. Some family members have been annotated as proteins containing tetratricopeptide (TPR) repeats, which may at least indicate mostly alpha-helical secondary structure.
Statistics
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PSSM-Id: 100115
View PSSM: cd05804
Aligned: 40 rows
Threshold Bit Score: 245.271
Threshold Setting Gi: 111224760
Created: 31-Jul-2008
Updated: 17-Jan-2013
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21911421  517 LDPGFTAGHAALALIghecgadvdv---pralaearrCARERADERER-SFVEVVSRRVEGSPaeGDAALLRHLDSHPGD 592
gi 159178912  45 ADDGFALGYAALARTrqamgmggd----tktpmaaaqALAGGLSAREA-AHVDALGLLVAGNGpaAYKAIRTHLLEHPRD 119
gi 146343377  45 LDPDFALAHAARARIhaiymqreaa---lqtikrardLVAKRGTEREK-SHVATLVLAIEGRGtdALHAALTHLESWPRD 120
gi 161381334  44 ADADFALPHVVLARYrqligdrtg----aklaletarQCKRVQTDRER-RQINIIGLLLAGQSaeGYRAAREQLKDYPRD 118
gi 27376405   46 ADPDFALPLIARARVhafyqqgdla---rqkaaaareLVAKRGTERER-SHVETLALAIEGRLpeAIEATLKHVEAWPRD 121
gi 134288234  46 ADPHFALAYAARARLhairaevsda---rskiaqateVVGRNGTERER-SHVQVLSFAINGQApkALAAALEHTDKWPRD 121
gi 162429652  46 ADPDFALAHAARARLhamcaepaqa---rariaaaaeRVARRGIERER-SHVEVLSLAINGQParALERALGHADAWPRD 121
gi 148360721  45 TDNLLIQTYAAAFYLyaqedvaneq---asdylqsasRLLTSANEREK-LTFEAVTNWSKRDYanAISLLVTLLERYPRD 120
gi 34499599   53 VGFDAITSCELKDLYkftl--------------clqqLAPEEADCPELrLLVAAFRAWVSFDYprARLLFRQHLDIYPSD 118
gi 87123573    8 AERGDVIPLQLLTALveltvqapdaqtravarlqqcqIQRQRLDAWGQ-QLLEAGLLWGAGALgsALRRLVDLAERAPEG 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21911421  593 RLala---aaVPTIAFSGLYDLDgsaalrvv---ertapahEGHWFHTSLLAFVRQEQGRYdEAGTLAEQALGEEPASGH 666
gi 159178912 120 AMiaqtctgvFGMIGFSGKPGREaeqlaft----aalaphyGEDWWFLCQHAFSQVEAGQTgPATETIERSLALHPRNAH 195
gi 146343377 121 AMimalplgaFGLLAFSGRRDHDaarrdlc----nrfaaayGEDWWFLSNHGWALTEAGEVsQGRAITERSFALRRHNAY 196
gi 161381334 119 VLiaqaclgvLSLIGFSGQPGREaenlala----eilephyGDDWWLQGLLGFAQVEVGQFdRAEQSIAKSLAANPRNAH 194
gi 27376405  122 AVvlslplgaFGLFAFSGMADHDrarhelc----ervarhyGEDWWFLTMSGWAMTENGDVaRGRGITERGFALRRQNAH 197
gi 134288234 122 ILilslplgaFGLFAFSGMANHDqarvdlce---rharhfdADDWWFLTYRGWAHGENGNVqLGRAMTQRSLELRRHNVN 198
gi 162429652 122 ALilslplgaFGLLAFSGMTDHDqarvdlce---rharhydADDWWFLTYRGWSHAENGAVkHGRALAERGFALRRANAN 198
gi 148360721 121 TLalk---fvEWLFYCTGQAFNAeyflkvc----dkcapenQDESHFLAIHSFALELCGQYsKAREMAEEAITMNLHTPW 193
gi 34499599  119 IVa------lFFTHMFDFCTGHTpelmpdlercdrhigedhPLYSYYLSIKAFVTVEAGHPaQALKLGLESLRHRADNIY 192
gi 87123573   87 LLvlk---iaEWLTYLRGQELHGpalldls----lifeashGSDPDWLAIHAFALELCGCCpEAIAAAQAAIGARSLNPW 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21911421  667 AMHALAHVHYEQGDhPQGRDRLDAWLGGHg-rGGTHRAHFAWHAALHELASDDaEAVRRRWATHLspgk--vagiRALVD 743
gi 159178912 196 AAHIRSHVYYEAGEtEAGYRYIDDWRRDYd-kAGQLHCHISWHVALWALERGDvETMWRVLDADVapdaawgpplNLVTD 274
gi 146343377 197 AVHALLHAMFEQGSlAEAGALVEGWIGDYd-rTGMLHGHICWHQALGALDRGDaAGALRVYTDVLlptmdtapplNTLSD 275
gi 161381334 195 GAHFQSHLYYETGQtDAGYVFITDWQSAYe-kEGQMHCHIAWHIALWALARGDiDEMWRIVDSDIdprgawgpplNVMVD 273
gi 27376405  198 AAHAVLHAMFEDGSiEAADRLVDEWIPTYd-rAGILHGHIRWHQALGALEHGDaARALAIYADVLqpsatqapplNVVTD 276
gi 134288234 199 AVHAVAHVLYECGAnDEAEGVIAGWLPEYd-kSGVLHGHIAWHAALIALERGDtDRAIAVYNEHVapsastgvpvNVVSD 277
gi 162429652 199 GAHALSHAMFEGGAgEEAEALIAEWLPGYd-rSGILHGHIAWHAALSALERDEpQRALAIYAEHVqpsvtaglpiNVVSD 277
gi 148360721 194 AHHTLAHVHLLTSDiTGGINRLRDLQKTWediLPLLKGHNTWHLALFYLANRDeEEVKKLYPHISgalp---dtvLEQLD 270
gi 34499599  193 GIHAVAHALHEQECwKELCLFLEQCKAQWi-dNAGMRMHVYWHLAIGYEKSQQtEQSVRTFHDMYalkd--srfaKQDLD 269
gi 87123573  160 ADHALLHAWHRQGDlDRALDWAGQRRASWseaLPAMRLHNRWHAALLSLEMGQpDRAIPALAEFRget-----gtGPLLD 234
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21911421  744 SGSLLWRARMAGhwqgrVPVDDVLESVAAdv---leRPATA-------FTALHAAVTLTAagdlPGLRRLQAHALgad-- 811
gi 159178912 275 TASLLYRAELAGv----AVPAERWKQVSDt-----aARIFPnpg--iaFADVHAALAHAMagngTALSKIIADAKg---- 339
gi 146343377 276 CASLLWRLRAENh----TLPDGAWTEVAAy-----aRPRFTgst--laFIEMHLVMIAAAtndtTALKGRLAAIErrqie 344
gi 161381334 274 LAAVLYRAELAGi----AVPQARWQVVCDy-----aAEHFPnpg--lgFADVHASLAYAMagrsEALERIITGAKg---- 338
gi 27376405  277 GASLLWRLSAYGh----AVPQELWLDADAa-----aQKLFPkss--lpFADVHMALFAAAtqnrDALAARLAVIEqrvae 345
gi 134288234 278 SASFLWRMQAYGh----SVPAGMWDEAARy-----aSGYFKqag--faFADFHMTLVAAAtgdkAALGQRVDDLVklvea 346
gi 162429652 278 TVSLLWRMQAYGy----KVPAGLWDDAKVy-----sSKYFTkag--faFADAHMGLLAAAtgdkAAAVARIDALTdlvaa 346
gi 148360721 271 TISLLWRMDMAG-----LPQDRLLNQVVDh------LSTHPlef-ytgFTNAHFIYCLVKsgykNEADESLKRMKsyaca 338
gi 34499599  270 AVAFLWRYRLNHpg--dNRFDDVWQQLAF-------LWSGSigasmshFHRLHAALAFAAsgqpVLIEKLIAESDgfgl- 339
gi 87123573  235 AIALGWWLDLSA-----APQETLWSSLVPlvqerlcLPLIP-------FIACHYAWCLGRagqqQDLETLLDHCRdqarv 302
                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 21911421  812 ------svQRAVIAPLCEAFaHVVEENWAeAAQRLERVLPalraVGGSAAQREVVEETLV 865
gi 159178912 340 -------pAGDLVRTLAEGFrAIADGEWEaATGHLTRSMAdherIGGSRAQRDLVEYALL 392
gi 146343377 345 ----gnlpAGRIVPHMLRALrAFAEENWRaCARELTPVMGdlarIGGSHAQREVIEDTYV 400
gi 161381334 339 -------pVAQLVSSLAEAFgAIADQNWTrANDLLTLALWdharLGGSRAQRDLIEYASV 391
gi 27376405  346 ----gklpAGPVVPAICRALaAFADEDYAaCVRTLAPALAdvvrIGGSHAQRELIEDTFI 401
gi 134288234 347 ----gqlpAGSVVPAICRAAlAFAEENYTlCAEILEPVARdvvrIGGSGAQREIVEDTLL 402
gi 162429652 347 ----gtlaAGPVVPAICRAVlAFAEEDYAgCVRILEPVAAevtrIGGSGAQREIIEDTLL 402
gi 148360721 339 p--ssdalWGDVVLPLCQGIyAFADADYKtALMLMEPVIGecaqLGGSDAQIELFFQTYL 396
gi 34499599  340 -----dpqTHQTGVTVLKGIhHFAEGRYAdSLGALQAAQPhwsvLGGSRAQRELLPLTLQ 394
gi 87123573  303 agpeagwcWRPAGLTLVEAIgAAACGRRAtAWELLAPIRGwidhAGGSDAQARVLHQTVR 362
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