Conserved Protein Domain Family
MPG1_transferase

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cd05805: MPG1_transferase 
GTP-mannose-1-phosphate guanyltransferase (MPG1 transferase), also known as GDP-mannose pyrophosphorylase, is a bifunctional enzyme with both phosphomannose isomerase (PMI) activity and GDP-mannose phosphorylase (GMP) activity. The protein contains an N-terminal NTP transferase domain, an L-beta-H domain, and a C-terminal PGM-like domain that belongs to the alpha-D-phosphohexomutase superfamily. This subfamily is limited to bacteria and archaea. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this group appear to lack conserved residues necessary for metal binding and catalytic activity. Other members of this superfamily include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine mutase (PNGM), phosphoacetylglucosamine mutase (PAGM), the bacterial phosphomannomutase ManB, the bacterial phosphoglucosamine mutase GlmM, and the bifunctional phosphomannomutase/phosphoglucomutase (PMM/PGM). Each of these enzymes has four domains with a centrally located active site formed by four loops, one from each domain. All four domains are included in this alignment model.
Statistics
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PSSM-Id: 100097
View PSSM: cd05805
Aligned: 24 rows
Threshold Bit Score: 475.968
Threshold Setting Gi: 83590759
Created: 11-Jan-2008
Updated: 17-Jan-2013
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17131453  384 LFGQRGVQGLANIDISPEFAVKLGAAYGSTLKPGAKVTVSRDQRNVSRMVTRSLIAGLMSVGVDIQNlDATAIPIARTVI 463
gi 86740169  379 LFGPRGVSGLVNAEITPELVVRLAGAYATTLKKGATVTTARDGSRAARALKRAVISALTAGAINVRDlEVAPMPVTRFDV 458
gi 72161798  384 LFGPRGVSGLINVEITPELAVRLASAYATTLKKGAVVTTARDASRAARTLKRAVISALTAAAINVQDlEATPLPLARFHT 463
gi 117928438 393 LFGPRGISGLVNVEITPEHTVRLGAAYATTLRKGDVVTVSRDASRAGRALARAMISALTASAVNVRDlEAIPAPVARFEI 472
gi 39998344  385 LFEGALIKGLTNMELTPEFVAKLGCAYGTTLPKGSFVISGRDAYRSSRMLKRSFIGGLLSSGVNVRDlTMVPMPVLRYKL 464
gi 77920548  387 LFEGASVRGLSNVELSPEFCAKLGAAYGSVLPRDSYVITSRDGQRSSRMLKRAFLGGLLSTGVNVRDiKQMPLPVMSYKL 466
gi 89210730  383 LFTNTGVIGEGNIDITPEFVTRLAVAFASTIDRNKSITVSSDTYGLTSALKRAVISGIQLAGRNVLElGEITTAVARYGI 462
gi 15606116  385 IFKGNKVIGRINVELTPDNATKLGMALGSVLPPKSTVILARDYHRASRTIKRSFLGGILSTGINVIDlHLSPLPVMRFTL 464
gi 108804273 388 IFRGGRVSGKFNVDVTPEFVIRLASSFGTTLSPGSIVTLGRDSSAAAQVVKRAMTAALLATGVNVRDlRAAHAGVVRHDV 467
gi 152992864 389 IFEDGRVTGKSNVEISCEMACQLAEAFAAHLPLGSTVIVGRDHSKSARMLKRAFLGGLLSGGVNIVDlKAMPPAVLRHNL 468
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17131453  464 PTMGVa-GGIHVRVHPDRaDYILIEFMDHKGINISKAQEKKIEGAYFKEDmrral-theiGDVAYPSQ----VIDLYCTA 537
gi 86740169  459 RSSNAa-GGIMLRTTPGDpERIDIIFLDADGDDLSPVAQRKLDRVFSRQEfrraf-pgeiGDLRFPAR----TMDLYIQD 532
gi 72161798  464 SQPGLs-GGIALRTTPGDpQSVDIVFLDSSGADLSPAAQRKLERVFSRQEyrraf-pgeiAELSFPSR----SVEAYTRE 537
gi 117928438 473 AHSDAv-GGVIVRTTPGDaQSVDVTLLDENGADLSPAQQRRLERVFSRQEfrraf-pgeiADITVPYR----TLETYSQE 546
gi 39998344  465 RSFGEv-GGIQFRQALDDpASTEIIFLDGDGLDFSSSMGKNVERIFFKENfrrahhtepgGLTEIPQQ----VMDFYREG 539
gi 77920548  467 GTFGEv-GGVHFHQFRDDpAATEIQFYDAEGFEISSGTAKSIERIFFKENfrrvh-yaepGEIRELPQ----LNAFYREG 540
gi 89210730  463 INMQAg-GGIHIRLSYNNpEKVVLEFMNEKGVNLPAPDQKRVEKKFFTEDynrap-vndiGDYALVPE----MVNEYLYG 536
gi 15606116  465 TEDKKavCGVYFSISQEFpGSVEICVFDENGLPIDTNFQKKIERVFFREAyrfet-ftdlGLIKEKPY----FSENYVTK 539
gi 108804273 468 LAGKSs-AGCHTRAGEDS-DEVEVLFFSSDATPMTEGEQRAIEKVFVREEyrrah-egdiGQLIFPGR----AVEQYVER 540
gi 152992864 469 GIKKElvAGIYFRQNVFDpTGVEFTFFSEEGLRIDGNMAKSVEKAFFQQDyrrvd-ydkiGRIEENYIhhlnECITYKKA 547
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17131453  538 FEKLLnvstlnnsraKVVIDYVYAVSg-AVLPQMLDkf--gaDAVVLNASLNk----nAVTTTd---rETLLTQLGHVVE 607
gi 86740169  533 LLDRVdtagvaeadlKIVVDSSGGSAs-LVLPTLLGrl--gvDVLTVNGRVDet--ipPRSALe---dLRATDRLGALVA 604
gi 72161798  538 LLQSIdlsgvaeanlKVVVDCAGGTGs-LILPALLSqi--daDVLTVNNRLDe----aSPTDTpa-krTRDLQRLGELVA 609
gi 117928438 547 ALRCIdtsgiaeaglKVVLDTAGGTAa-LVLPTLLGri--gvDVLTVNNRLDe----lSPTETta-ehMRALERLGDLVS 618
gi 39998344  540 FLHAIgktplqkkafKVVIDFNHSPAs-QLLPGILTqm--gcEVISLNAYVDeergvqALSDR-----GQSLSQLSKIVA 611
gi 77920548  541 FQRALdaqllrsfapKVVIDLNHSPAg-ELLPGLLSdl--gcEVVALNSHVEag--rsAVTPEq---tSRAMEQLARITG 612
gi 89210730  537 ILDTVdteaikrnyfSVVIDYEYDSLn-HLLPLLLKrlncqmLSTRNYSRTGr-----PLSLQe---rLEARDKVSRILN 607
gi 15606116  540 LLSSIdgdsiklssnKVVYDALHSPIs-PFISEVLGkl--eiENVILNALYDer--klSRISTy---aSSSEGNVSKVLK 611
gi 108804273 541 LERAVdrsr--vsggSVVVDFCGGVAg-LVASRVFSrlgisaVVMEGFANANvvg-gaPRMDL-----EEGLERVGRIVP 611
gi 152992864 548 VKEAIdhkiikkngfRVAIDLMYGGTkdIFPEIISElq---iENIILNSYTDy-----HKMANmahveKKSKDDISAIVK 619
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17131453  608 ALKANFGVQVSANGEQLILVDESGYPI-RGELLTALMVDMilts---nprGTVVVPVHASSAVEQVARRHDGRIIRTKAN 683
gi 86740169  605 SSGAAFGVRFDHVGERVTIVDERGDLI-DDDRALLVFLDLvaae---npgAEVALPVTITRVADQVTRFHGLTVRRTSLS 680
gi 72161798  610 SARADFGVRFDPVGERIQLVDGSGTLV-DDERALLVVLDLvaae---rqgGRVALPVTTTRVAEQVANRHGVDVQWTPTS 685
gi 117928438 619 SSHAAFGVRFDAMGERLSLVDERGVII-HDDRALLVFMDLvaae---rrgGRIALPVTTTRVAEAVARFHGATIEWTPTA 694
gi 39998344  612 TLEANAGFWLDPTVEGVIMVDETGTVHeGADILLLMVGLAlka----gekGVFAIPVSAPSAIERMAQERGCAVTRTKSA 687
gi 77920548  613 TLEATAGFWLDPSGEQLRIIDESGVLLsETEALGVVVSLVsrc----estGNLVLPVSAPMAMERIAQDGGLTTRAVKND 688
gi 89210730  608 ENEADLGIIVDHNAERLNLVAGNKQVL-DPFKYQVMLSYLlle----rgvKKLFVPFNSPKVIENIADDYDADVVYTPLA 682
gi 15606116  612 ALSYDVGFVMEPSATKLKLVDDRGRTI-SGDRLLLVVLMLldks--aekqLRVYLPVWAPEVLDAILNNVIVERGKFTNL 688
gi 108804273 612 TVEAAFGCVVNPTGEQVHFVDDAGEYVpPDVMLACLIRGLe--------pREVVLPINLSSRYAELVESYGGTVHYARTG 683
gi 152992864 620 NLKFNIGFLMYPNGQQLGIVGDDGEVLgRIKGLFVVLSLLnleakekekkLNVFLPTWAPDLTDELFENLVIERGKYANF 699
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17131453  684 ATALMEAcqknpnvVLGGSGETGFIFPqlhpGFDSMFCIAKIIEMLTIQERSLATVRSELPRVIYRTHTIRCPWSAKGAL 763
gi 86740169  681 AAALTGVard-dgiVFAADGRGGFIVPefapAIDGIAAFVKLLALVARTRLTLSTIDARIPSVAILRRSVPTPWAVKGTV 759
gi 72161798  686 LDALTKAala-ddiIFAADGRGGFILPefsrTCDGIAAFVRLIGLVARTKMSLSQIDQRIPQAHLLRRSVPTPWAVKGSV 764
gi 117928438 695 PSELTRAarr-gdvIFAGDGRGGYIVPefsaALDGLAAFVRLTGLVARTKLTLSQIDGRIPQAHVLRRVVPTPWAAKGLV 773
gi 39998344  688 DRSMIEAals-sevILAGSMDGRFAFPrfqaAFDGMFAIAKSIEMAARSGASISATAAEIPRRAFLHTRVPCVWDMKGGI 766
gi 77920548  689 ARALLEAvae-rggLLTATMDGRFALPvfqgHFDGMFAAAKILEMLGRTGMSLGAMRRTLPARAYRHTQVPCSRQLKGGL 767
gi 89210730  683 PQVSMEK-------YMVYEHNPFKFYP----FNDAIAALVLILEKMAVENISFEQLLNRLPEFYLERVEIPCEWHDKGRV 751
gi 15606116  689 RKSFIEDf------YMLADTDGSFTFTefsySPDALYASLKIMEMLTKLKVKVSEIYDSLPEYYFLHEVVSCSSEKKGTV 762
gi 108804273 684 MGNVAIRaae-raaDLGGLEDGQYIFPaflpAPDCFMTLARALELFRDRPLSKVRREFGERFGNVVRERLECPWSAKGRV 762
gi 152992864 700 KADKVKKy------DLVATIDGNFAFTefslHRDAMYASLKIMEMLSRHQVTISDISKQFERFYYNHIEVECSQAQKGKM 773
                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 17131453  764 MRYLVEthpaq---nlelIDGVKIRQpfddSWLLVLPDASEPLVHLYANSHERDWVDETVRDYRSRV 827
gi 86740169  760 MRRVVEsvdpdtgyvidtTDGVRIVGpd-gSWILVLPDPSEAVTHLWSEGADIEEAHVLLRRWVEVV 825
gi 72161798  765 MREVVEaaqgr---eidtTDGVRVIEpd-gSWALVLPDTAEAVTHLWAEGPDDETAQRLLEEWSAVV 827
gi 117928438 774 MRSVLHaaggk---pvetTDGVRIVEde-qSWVLVLPDPAEAITHLWAEAPDADAATELLEKWASVI 836
gi 39998344  767 MRKMSEdsldk---easfIDGIKVHFg--eDWALVLPDQYQPHVHIVAEARDPKAAQKLLTEYQKKV 828
gi 77920548  768 MRKMSEhsvnl---dasfIDGVKVRFd--dDWVLVLPDQYRPVMHIVADSPDAQRAESLLVSYQGKV 829
gi 89210730  752 MRRLAEeard----ntelVDGIKFNHr--nGWALVIPDNEEPVFHIFAEGQDEETAESLTGFYIEKV 812
gi 15606116  763 LRKISEmaegk---easfIEGVKIYEdy-gNWVLVLPDSYKDLIHVYVQSTERERAEELIKNYMEIV 825
gi 108804273 763 MRGLAErfggd--pdailTEGVKLMVd--gGWVLMLPDPDNPLFYVYAEADDGRRPEALMQDYVRLV 825
gi 152992864 774 MKRFFQeakdk---ksctTDGVKIWEne-tDWILMIPDQVRDLLHLYVQAKDKNSGEALAARYEANI 836
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