Conserved Protein Domain Family
LbH_wcaF_like

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cd05825: LbH_wcaF_like 
wcaF-like: This group is composed of the protein product of the E. coli wcaF gene and similar proteins. WcaF is part of the gene cluster responsible for the biosynthesis of the extracellular polysaccharide colanic acid. The wcaF protein is predicted to contain a left-handed parallel beta-helix (LbH) domain encoded by imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes showing acyltransferase activity. Many are trimeric in their active forms.
Statistics
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PSSM-Id: 100063
View PSSM: cd05825
Aligned: 29 rows
Threshold Bit Score: 145.056
Threshold Setting Gi: 46204520
Created: 25-Jan-2008
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
Feature 1:putative active site [active site]
Evidence:
  • Comment:Based on the structures of E. coli galactoside acetyltransferase and Enterococcus faecium streptogramin acetyltransferase Vat(D) bound to CoA and their respective substrates.
  • Comment:Active acetyltransferases in this family are trimeric, with active sites located at the interface between two LbH subunits. The trimer structure contains three active sites and each subunit contributes to two active sites via residues located on two surfaces.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                  # #                             # #                  # ##    #        
P0ACD2        69 PWKLTLGDYAWVGDdVNLYTlgeITIGAHSVISQkSYLCTGSHDHAsqhftINATPIVIGEKCWLATDVFVAPGVTIGDg 148 Escherichia col...
ABA81565      72 PWRLRVGDNSWIGEdVWIDNlapVIIGSNVCISQgVYLCTGSHNWScatfdLITSAISIGDGAWVAAQSTVGPGVSIGEg 151 Rhodobacter sph...
YP_557192     93 PWNLEVGDNCWFGVdVWIYNqtlIRIGSNVCISQgTFLTAGSHDMStt-mdLHVAPIVIEDGVWITSKCVVQMGVTIGRs 171 Burkholderia xe...
YP_825900     70 PWFLEIGDHSWIGEdVWIDNlalVQIGANVCLSQgAYLCTGNHDWSdpafgLIVQPIVIHAGAWVGAKTIVGPGAVIGLq 149 Solibacter usit...
ZP_01883669   71 PWHLTVGDHTWIGEkVWIDNlvtVHIGPNVCLSQgAMLLTGSHNYKspafdLITGSITLHEGCWVGARAILNQGIEMSAh 150 Pedobacter sp. ...
YP_890176     74 PWKLTIGDNSWIGVgSELYNldqIVIGSDVCISQhVFLCTGSHDRRsptfeFDNGPITIEDGAWVCARSTVLRGVRIGAn 153 Mycobacterium s...
YP_001303558  71 PWNLSIGDYSWIGEnVWIDNlvrVTIGSNVCISQgAMLLCGNHNYKrqtfdLIVKSIVIEDGAWVGAQSTVCPGVTMHSh 150 Parabacteroides...
YP_001011690  69 PWNLSIGDHCWIGEdVWIDNlalVKIGNRVCISQgVYLCTGNHNYKkdlfnLILERIVIEDDCWIAAKSIIAPGAILKRg 148 Prochlorococcus...
YP_949783     70 PWKLTLGDNVWIGVdAWILNlepVTIGSDCCISQgVLLCTGSHSFDsptfeFDNAPIVIGDGSWIGARATVLRGVNVGDa 149 Arthrobacter au...
YP_001361579  80 PWKLTVGNSSWIGQdTWLLNlepVVLGDDVCLSQgVLLCTGSHDRRsptfeFDNAPITVQDGAWIAAQATVLRGVTVGAd 159 Kineococcus rad...
Feature 1           ##    ##        ##  #    
P0ACD2       149 TVVGARSSVFKSLPAnVVCRGN-PAVVI 175 Escherichia coli K12
ABA81565     152 AVLGLGSTATKDLEPwTINCGL-PAVRL 178 Rhodobacter sphaeroides 2.4.1
YP_557192    172 AVVTPLSVVHRSLEAeGVYGGN-PCRFI 198 Burkholderia xenovorans LB400
YP_825900    150 AIATAGSVVTGNLDPdTIYSGN-PAVAR 176 Solibacter usitatus Ellin6076
ZP_01883669  151 AVLSTGSVATKNMEPyTIYQGN-PALKV 177 Pedobacter sp. BAL39
YP_890176    154 SVVGAMSLIQRDVPAdSLVQASqPTVSR 181 Mycobacterium smegmatis str. MC2 155
YP_001303558 151 SVLAVGSIASKDLMSySIYRGN-PAVKV 177 Parabacteroides distasonis ATCC 8503
YP_001011690 149 SVTCLGSLVSGILEKdGIYKGN-PAKLF 175 Prochlorococcus marinus str. MIT 9515
YP_949783    150 CLVGASALVVKDVPPgARLLAS-IGTSR 176 Arthrobacter aurescens TC1
YP_001361579 160 AVVGACALVVRDVPAgATVLAP-AATWP 186 Kineococcus radiotolerans SRS30216

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