2LN7


Conserved Protein Domain Family
Sortase_D_1

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cd05828: Sortase_D_1 
Click on image for an interactive view with Cn3D
Sortase domain found in subfamily 1 of the class D family of sortases
Class D sortases are cysteine transpeptidases distributed in Gram-positive bacteria (mainly present in Firmicutes). The prototypical subfamily 1 of class D sortase from Bacillus anthracis (named Ba-SrtC) covalently attaches proteins bearing a noncanonical LPNTA sorting signal, such as the BasH and BasI proteins, to the peptidoglycan of the cell wall that facilitate sporulation. BasH is exclusively anchored to the forespore cell wall envelope, while BasI is attached to the diaminopimelic acid moiety of the peptidoglycan of predivisional cells. Ba-SrtC lacks the N-terminal signal peptide and membrane anchor. The family also includes many class D sortase homologs from Gram-negative bacteria, but the functions of these enzymes are unknown.
Statistics
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PSSM-Id: 320677
View PSSM: cd05828
Aligned: 209 rows
Threshold Bit Score: 109.893
Threshold Setting Gi: 256007477
Created: 31-Aug-2006
Updated: 18-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
 
catalytic siteputative active
Conserved site includes 3 residues -Click on image for an interactive view with Cn3D
Feature 1:catalytic site [active site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                               #                        
2LN7_A        13 GEKVAMLNIPk---lKKKFSIYWGADDatLKKGVGMFVsdvtttpsggGHTVLSGHRD-TVFTDLGQLkeKDTLVLEYd- 87
gi 524640031  95 GEQYATLSCDs---iSLNVPVYWGTTAalLERGACQATssvv--lgnpGNVVIDAHVN-TFFAHLDQMsvGDTVVLYTq- 167
gi 524807101  89 GEQFAVLRSDa---lSLSIPVYWGSSSelFEHGACQASdsai--vgteGNAVISAHVN-TFFSDLNKLkkGDIVTVNTq- 161
gi 524316727 109 GDKYATLNCEaa--gMNDIPVYSGTTNdiLAEGAGWYNgsvy--ighvGNVVLAGHNH-TYFYNLPKCkkGDEVTLETs- 182
gi 571258597  87 GDKYAELTVKndkagIDKEPVYWGDSDdlLAKGVVQSNysay--igatGRVVLAAHNH-TYFRYLPNIlvGDQVILKTd- 162
gi 914821567  81 GEEFGKITIDk---iGVVSPIFQGDVEaiLSKGAGHFYgsal--pgegSNVVISAHRN-TQFTRLGELvpGDVVTLDTt- 153
gi 917723166 129 GTEFATVQIPs---iNLIYPVMQGDTEalLSQGVCHFYgsdl--pgenSSILFTAHRT-THFSGIGALepGDSVTVDTs- 201
gi 511593070  93 NGILGHLIYD-----GKSVVVRDDIDAdtLEKSPGWVPdssl--pgnsGMSIIFGHRNrKHLKLIEPIevGDTISFRFvs 165
gi 511593436  92 ADTFCTLTIC-----GKDIPVRYGVDEktLEKSPGYLPssal--pgaeGTCAIYGHRNrNHFKALKNAqvSDSIKVTMad 164
gi 514048738  87 GKAFFTLSIL-----NDTISVAYGVEEstLKKTPGWLTtsvl--pgenGMCVVYGHRNrNHLKILEKVtvGDIITATKd- 158
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                #           #       
2LN7_A        88 -nKTYTYEIQKIWITHAddrtv-----iikkeEPILTLTTCYPFDYigDAPDRYIIEAKL 141
gi 524640031 168 -yGRFTYEVSETVTFQKtdkry-----vipteDDRLTLYTCINNVFg-SSDDRYAVICKL 220
gi 524807101 162 -yGYFTYEVSEIIEFKKsdkky-----viptkDTKLTLYTCKTDILg-SSDIRTGVVCTL 214
gi 524316727 183 -yVKQTYMVTDIEIFHEddqty-----vrptdDDRLTMYTCWNNGMlgMSEYRIAVICEL 236
gi 571258597 163 -yGKFTYEVTETKVLPDtdtsllyydvtadppVDDLILYTCWNNGYmgLSDQRLYVICKV 221
gi 914821567 154 -aGKFVYEMQDSVIFPDydeqy-----ilstpGEVLTLLTCYPFDFigAAPDRYIVRCQL 207
gi 917723166 202 -wGTYEYAVDEAMILYPadiag-----llnasQETLYLITCYPFNFigGAPQRYAVRCHL 255
gi 511593070 166 dnRLVSYEVTDVQIFEKtsdwt-----lpvtdEDVLVLVTCYPFEYtgNAPGKFQVLARL 220
gi 511593436 165 -gTVYTYVITDITIFEStsdwt-----lpaadGRMLTLVTCYPFQYsgHAPGKCVVTARL 218
gi 514048738 159 -gIAYTYAVLDVAIYEStsdwr-----lptldRSTLVLVTCYPFRYsgHAPGKYMVIARL 212

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