Conserved Protein Domain Family
Ribosomal_P1

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cd05831: Ribosomal_P1 
Ribosomal protein P1. This subfamily represents the eukaryotic large ribosomal protein P1. Eukaryotic P1 and P2 are functionally equivalent to the bacterial protein L7/L12, but are not homologous to L7/L12. P1 is located in the L12 stalk, with proteins P2, P0, L11, and 28S rRNA. P1 and P2 are the only proteins in the ribosome to occur as multimers, always appearing as sets of heterodimers. Recent data indicate that eukaryotes have four copies (two heterodimers), while most archaeal species contain six copies of L12p (three homodimers) and bacteria may have four or six copies (two or three homodimers), depending on the species. Experiments using S. cerevisiae P1 and P2 indicate that P1 proteins are positioned more internally with limited reactivity in the C-terminal domains, while P2 proteins seem to be more externally located and are more likely to interact with other cellular components. In lower eukaryotes, P1 and P2 are further subdivided into P1A, P1B, P2A, and P2B, which form P1A/P2B and P1B/P2A heterodimers. Some plant species have a third P-protein, called P3, which is not homologous to P1 and P2. In humans, P1 and P2 are strongly autoimmunogenic. They play a significant role in the etiology and pathogenesis of systemic lupus erythema (SLE). In addition, the ribosome-inactivating protein trichosanthin (TCS) interacts with human P0, P1, and P2, with its primary binding site located in the C-terminal region of P2. TCS inactivates the ribosome by depurinating a specific adenine in the sarcin-ricin loop of 28S rRNA.
Statistics
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PSSM-Id: 100109
View PSSM: cd05831
Aligned: 51 rows
Threshold Bit Score: 59.6427
Threshold Setting Gi: 67473776
Created: 2-Aug-2007
Updated: 17-Jan-2013
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31979223    6 ELACIYSALILHDDEVTVTEDKi-nALIKAAGVNVEp-FWPGLFAkaLANVNIGSLIcnv---------gaGGPAPAAGA 74
gi 76159841    5 ELACVYAALMLADDDIDVTADKi-nTILKAANIKFVesYLPNLFAtsLNGKNVKDLLmsmgsp--apsaavTSAVPTAAS 81
gi 6094104     5 TLACTYAALMLSDAGLPTSAENi-aAAVKAAGVSVRp-TMPIIFArfLEKKSVEALMaaaatq--aptatsAAAAPAAGE 80
gi 133055      6 QLACTYAALILADSGKTDMDSLl--KVTKAAGVDVSk-GMASAFAsiLKNVDINDVLskvsfggvapaaggATAAPAAAA 82
gi 145502731  18 EAACTYAALILYEDNQEINAAKl-aQIIKAANLRVEp-IWTKVFEkaLKGKKVGDLLhg-----------nSGSAPAAQV 84
gi 66806411    1 MSALDYATLILHDAKLAITADNl-vALCNAAGVKVEk-FKADLYAstLEKKKVDSILsv----------saAAAAPAAAA 68
gi 159112575   5 ETACVLAAIILADENQEPTAANl-kSICDAAGVKVDs-IWFTLFAnyLEGKNVKELLttl---------gsASAAPAPVT 73
gi 170109099   5 ELAPTYAALILADDGIGITAGRi-lALTTAAGVDMEp-IWADLLAkaLEGKEIKELLshidpg--gnldngTSAVIASNT 80
gi 72389122    4 QLACTYASLILSGSGNVDAAKLl--AVTNAAGVTVSk-GMAEAFAsiLGGISIDEVLgni---------afGGGAPVASS 71
gi 89292119    6 HQACTYAVLLLSDDGQAITVDNinkVLTKAKVQNVEk-YLPKLYVsnITPAVIASTIangg-------sssSGSAPAAAA 77
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 31979223   75 APaggpapstaaapaeekkvEAKKEESEEs-------DDDMGf-GLF 113
gi 76159841   82 ATsaaaek------pkeavkEEKKVVSDDd------sDESIGf-GLF 115
gi 6094104    81 ASgk--------------aeEKKKEEPEEe------gDDDMGf-GLF 106
gi 133055     83 AAaap------------aaaAAKKEEEEE--------DDDMGf-GLF 108
gi 145502731  85 ATtaapvaqq--tkapeaakEVKKAEEPEe-------DVDMG--GLF 120
gi 66806411   69 APvaaa-----------aaaPAKKVVEEKke----esDDDMGm-GLF 99
gi 159112575  74 AGgavaaa-------aaaaeTAKKEESDD--------DEIVGagGMF 105
gi 170109099  81 AAtt--------------dsEGHVDESGEsqdgddseDEIIFs-GLM 112
gi 72389122   72 GGaaaaapaa---ggapaaaAPAKEEEED--------DDDMGf-GLF 106
gi 89292119   78 VAkea-------------pkEEKKAEEIKfn----alNQNINenIVF 107
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