Conserved Protein Domain Family
Ribosomal_P2

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cd05833: Ribosomal_P2 
Ribosomal protein P2. This subfamily represents the eukaryotic large ribosomal protein P2. Eukaryotic P1 and P2 are functionally equivalent to the bacterial protein L7/L12, but are not homologous to L7/L12. P2 is located in the L12 stalk, with proteins P1, P0, L11, and 28S rRNA. P1 and P2 are the only proteins in the ribosome to occur as multimers, always appearing as sets of heterodimers. Recent data indicate that eukaryotes have four copies (two heterodimers), while most archaeal species contain six copies of L12p (three homodimers). Bacteria may have four or six copies of L7/L12 (two or three homodimers) depending on the species. Experiments using S. cerevisiae P1 and P2 indicate that P1 proteins are positioned more internally with limited reactivity in the C-terminal domains, while P2 proteins seem to be more externally located and are more likely to interact with other cellular components. In lower eukaryotes, P1 and P2 are further subdivided into P1A, P1B, P2A, and P2B, which form P1A/P2B and P1B/P2A heterodimers. Some plants have a third P-protein, called P3, which is not homologous to P1 and P2. In humans, P1 and P2 are strongly autoimmunogenic. They play a significant role in the etiology and pathogenesis of systemic lupus erythema (SLE). In addition, the ribosome-inactivating protein trichosanthin (TCS) interacts with human P0, P1, and P2, with its primary binding site in the C-terminal region of P2. TCS inactivates the ribosome by depurinating a specific adenine in the sarcin-ricin loop of 28S rRNA.
Statistics
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PSSM-Id: 100111
View PSSM: cd05833
Aligned: 53 rows
Threshold Bit Score: 61.5105
Threshold Setting Gi: 71744668
Created: 2-Aug-2007
Updated: 17-Jan-2013
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 133070      1 MKYLAAYLLLTVGGKqSPSASDieSVLSTVGIEAEAERVESLIseLNGKNIEELIAAGNEKLstvp---------sagaV 71
gi 168007021   1 MKVVAAYLLCLLGGNaSPSAKDieAVLGSVGAEADSARVRLLLkeLEGKDILEVIAAGKEKFasvpsg-----ggggvvV 75
gi 3122774     2 MKYLAAYLLSTMSGNkSPSAKDieDVLGSVGLDVDMEDANKVVsaLSGKSIDEVITAGLAKVssvps-------daavsA 74
gi 116782363   1 MKVVAAYLLAVLGGNtSPSSDDikSILGSVGVDSDDDKIDYLLsqLEGKDITEVIASGREKFaavpsgggvavavsgggG 80
gi 58268766    1 MKLIAAYLLLQQGGNaSPSAADikALLETVGVEAEEDRLSKLIseLEGKDINELIAEGSSKLasv-----------psgG 69
gi 56757219    1 MRYLAAFLLCQLGGKeKPTENDikTVLNSVGIEHDSERLTKLLasLSGKDIPQLIAEGSQKLssvpt--------agaaV 72
gi 75273208    1 MKVIAAFLLAKLGGNeNPTSNDlkKILESVGAEIDETKIDLLFslIKDHDVTELIAAGREKMsalssgg---pavamvaG 77
gi 125560770 127 MRFVSAYLMAYIGGNeSPSKDDvrAILGSVGADVDEAKLDLLFeeIAGKDVPELIAAGRERLalaapc-----ggiaaaA 201
gi 75264340    1 MKVAAAFLLAVLGGNaNPSADNikDIIGAVGADVDGESIELLLkeVSGKDIAELIASGREKLasvpsg------ggvavS 74
gi 77416939    1 MKVIAAYLLAVLGGNtCPSEKDlkKILASVGAEADDDRIQLLLsqVDGKDITELIAAGREKL-----------------A 63
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 133070     72 ATPAAGGAAgaeat----------saaeEAKEEEAAEe-sDEDMGf-GLFD 110
gi 168007021  76 ASASAGSGGaapaa----------evkeEPKKEEEKEe-sDDDMGf-SLFD 114
gi 3122774    75 IAPVVSATPtdalqa--------gskkgETKEGPKEEs--DEDMGf-GLFD 114
gi 116782363  81 GAPAAAAAEpea--------------kkEEKVEEKEEs--DEDMGf-SLFD 114
gi 58268766   70 AAPAAAAGGaaagga-------aeaapaEEKKEEAKEe-sDDDMGf-GLFD 111
gi 56757219   73 SAPSSAPTApakaev-------pkaeskPAKTEVKEEsesEEDMGf-GLFD 115
gi 75273208   78 GGGGGAASAaepv------------aesKKKVEEVKDe-sSDDAGmmGLFD 115
gi 125560770 202 AGGQVVAAGgaaaa----------aaeeEEAEEEKKEeeeDDDDGlfNLFD 242
gi 75264340   75 AAPSSGGGGaaap-----------aekkEAKKEEKEEs--DDDMGf-SLFE 111
gi 77416939   64 SVPAGGGAAccscctwwcavllhlllrrRRKKRKWKKk-rCQMMTwaSVFS 113
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