1N27,2B8A


Conserved Protein Domain Family
HDGF_related

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cd05834: HDGF_related 
Click on image for an interactive view with Cn3D
The PWWP domain is an essential part of the Hepatoma Derived Growth Factor (HDGF) family of proteins, and is necessary for DNA binding by HDGF. This family of endogenous nuclear-targeted mitogens includes HRP (HDGF-related proteins 1, 2, 3, 4, or HPR1, HPR2, HPR3, HPR4, respectively) and lens epithelium-derived growth factor, LEDGF. Members of the HDGF family have been linked to human diseases, and HDGF is a prognostic factor in several types of cancer. The PWWP domain, named for a conserved Pro-Trp-Trp-Pro motif, is a small domain consisting of 100-150 amino acids. The PWWP domain is found in numerous proteins that are involved in cell division, growth and differentiation. Most PWWP-domain proteins seem to be nuclear, often DNA-binding, proteins that function as transcription factors regulating a variety of developmental processes.
Statistics
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PSSM-Id: 99895
View PSSM: cd05834
Aligned: 17 rows
Threshold Bit Score: 105.83
Threshold Setting Gi: 125774903
Created: 27-Nov-2007
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
putative
Conserved site includes 6 residues -Click on image for an interactive view with Cn3D
Feature 1:putative chromatin binding site
Evidence:
  • Comment:Possible chromatin binding property is supported by its charasteristic electrostatic charge distribution. Upon binding, the charged surfaces may form nonspecific contacts with the nucleic acid on the basic side and contact the core histone molecules along the acidic surface.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                     #  #  #                      #  # #                                 
1N27_A          7 GEYKAGDLVFAKMKGYPHWPARIDElpegavkppaNKYPIFFFGTHETAFLGPKDLFPYKEYKDKFGks---------nK 77
gi 47208425     7 DRLKAGDLVFAKMKGFPYWPARVCKsea----gykKRVPVFFFGTHQIGHLPPRNIVPYTGNKLKYGgg---------tF 73
gi 53983015    16 GKLILGDLVLARVKGFPAWPAKVSRpeewdrapdpKKYFVQFFGTQEIAFVAPPDIQPFTSESKSKLlarc-----qgkT 90
gi 125772733    8 KSFSINDLVFAKVKGYPAWPAKITKyi-------nKKYNVYFYGTGETANIKIEDLFPYVENKEKFAtdk-------nmK 73
gi 91086633     5 RSFKEGDKVFAKIKGYPAWPAVILAks-------gKKFNVQFYGTGETGFIKPEDIFYYLKNKEQMVkg---------sK 68
gi 71980552    11 HNFQPGDLIWAKMKGFPPWPAKVLErsed---apaRRIPVMFFGTLETSFMKPNDLSDYLPNRLIHEip---------rK 78
gi 115474313   16 TQPQLGDLVLAKVKGYPPWPAKVSKpedwdqmpvpRKVFVVFFGTREIAHIALPDLQPFTENAKSEVmdrsrnkqcpkkY 95
gi 115473797   21 AQWKVGDLVLAKMKGFPAWPAMISEpekwglssakKKLLVYFYGTKQIAFCNYTDLEAFTEEKRKSLlak------rhgK 94
gi 66500639     6 KKFFAGDKVFAKVRGYPPWPAKVEKvidp--nsknSKYSVYFYGTGETAVCKVEELYTYIENKAKFGkp---------lR 74
gi 156537071    6 KRFSVGERVFAKVRGYPPWPAKIESitdp--tskqAKYHVSFFGTKEIGTCKIEDLLVYADNKDKLSks---------vR 74
                          90
                  ....*....|....
Feature 1                       
1N27_A         78 RKGFNEGLWEIENS 91
gi 47208425    74 FKGFAEGMWEIQNS 87
gi 53983015    91 VKYFAQAVTEICTE 104
gi 125772733   74 RAKFSEAMDQIESA 87
gi 91086633    69 KKEFKDAVEQIEKA 82
gi 71980552    79 QKDFNKAVQEIRKA 92
gi 115474313   96 IDSFAEAVVEICKA 109
gi 115473797   95 GADFVRAVKEIVEI 108
gi 66500639    75 RKFFHEGLVQLEQE 88
gi 156537071   75 RKYFHEGIQELEED 88

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