Conserved Protein Domain Family
Dnmt3b_related

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cd05835: Dnmt3b_related 
Click on image for an interactive view with Cn3D
The PWWP domain is an essential component of DNA methyltransferase 3 B (Dnmt3b) which is responsible for establishing DNA methylation patterns during embryogenesis and gametogenesis. In tumorigenesis, DNA methylation by Dnmt3b is known to play a role in the inactivation of tumor suppressor genes. In addition, a point mutation in the PWWP domain of Dnmt3b has been identified in patients with ICF syndrome (immunodeficiency, centromeric instability, and facial anomalies), a rare autosomal recessive disorder characterized by hypomethylation of classical satellite DNA. The PWWP domain, named for a conserved Pro-Trp-Trp-Pro motif, is a small domain consisting of 100-150 amino acids. The PWWP domain is found in numerous proteins that are involved in cell division, growth and differentiation. Most PWWP-domain proteins seem to be nuclear, often DNA-binding, proteins that function as transcription factors regulating a variety of developmental processes.
Statistics
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PSSM-Id: 99896
View PSSM: cd05835
Aligned: 14 rows
Threshold Bit Score: 94.358
Threshold Setting Gi: 50401183
Created: 27-Nov-2007
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
putative
Conserved site includes 6 residues -Click on image for an interactive view with Cn3D
Feature 1:putative chromatin binding site
Evidence:
  • Comment:Based on sequence similarity to other PWWP proteins.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                   #  #  #                            #  # #                             
1KHC_A         12 FGIGDLVWGKIKGFSWWPAMVVSwkatskr-----qampgmRWVQWFgDGKFSEISADKLVAlglfsqhfnlatfnklVS 86
gi 118097276  654 ICVGDIVWAKIYGFPWWPARILTitvsrkdn---gllvrqeACISWFgSPTTSILALSQLSPflenfqs--rfnkkrkGL 728
gi 47221696   564 VAVGDIVWGKIHGFPWWPARVLSisgtrkqettsceaqwpqAKVAWFgSPTTSQLSVAKLSPfrelfrs--rfnrkkkGM 641
gi 160140805  488 VAVGDIVWGKIHGFPWWPARVLDislgqked---gepswreAKVSWFgSPTTSFLSISKLSPfseffkl--rfnrkkkGM 562
gi 115638547  855 IFRGQLVFGKMKGFCWWPGRIVHhydrsir----eppppltRWVQWFgDDKYSLLSLGQIAGledfpdyfsvsafqkwGL 930
gi 66472506   835 FAVGELVWGKVKDFSLWPGLVVPwkgri--------vpvsmRRVEWFgDGMFSEIHTDGLLPfgafsknfcsksyeglPT 906
gi 110769724  568 MDVGDVVWGKIHGFPWWPGKVLSitvscked---gtssgpqAHVAWYgSSTSSLMSCDQLSPfletfkt--rynkkkrGP 642
gi 156358282  440 INEGSIIWGKVHGHPWWPGRVMAitevvdd----qggvdtfAHVTWFgSNTSSEMPVQELQDfepnfrr--rykkdkkGC 513
gi 72074395   461 VCVGDIIWGKITGFPWWPGRIVQiivtrsne---ggitlqeAQITWFaSRSISFMPLTKLPPflgefkk--hydkkrkGL 535
gi 66472742   628 YIVGEMVWGPLEGFGLWPGLVQSwdsrk--------pcgsmRKVFFFgNSMQSEIQADDLTPffsfakcfssnsfatvAT 699
                          90
                  ....*....|..
Feature 1                     
1KHC_A         87 YRKAMYHTLEKA 98
gi 118097276  729 YRKAVTEAAKAA 740
gi 47221696   642 YRRAILEAAKAV 653
gi 160140805  563 YRKAITEAANAA 574
gi 115638547  931 YQKACYEALNVA 942
gi 66472506   907 YKNAIYQILELA 918
gi 110769724  643 YKEAIRQAQNEA 654
gi 156358282  514 YRRAVRQAQETL 525
gi 72074395   536 YKEAISQATKAA 547
gi 66472742   700 YKDAIFNSLQVA 711

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