Conserved Protein Domain Family
N_Pac_NP60

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cd05836: N_Pac_NP60 
The PWWP domain is an essential part of the cytokine-like nuclear factor n-pac protein, or NP60, which enhances the activity of MAP2K4 and MAP2K6 kinases to phosphorylate p38-alpha. In a variety of cell lines, NP60 has been shown to localize to the nucleus. In addition to the PWWP domain, NP60 also contains an AT-hook and a C-terminal NAD-binding domain. The PWWP domain, named for a conserved Pro-Trp-Trp-Pro motif, is a small domain consisting of 100-150 amino acids. The PWWP domain is found in numerous proteins that are involved in cell division, growth and differentiation. Most PWWP-domain proteins seem to be nuclear, often DNA-binding proteins, that function as transcription factors regulating a variety of developmental processes.
Statistics
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PSSM-Id: 99897
View PSSM: cd05836
Aligned: 8 rows
Threshold Bit Score: 149.142
Threshold Setting Gi: 91081069
Created: 1-Feb-2008
Updated: 17-Jan-2013
Structure
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Aligned Rows:
 
putative
Feature 1:putative chromatin binding site
Evidence:
  • Comment:Based on sequence similarity to other PWWP proteins.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                  #  #  #                          #  # #                               
gi 71297202    6 LRLGDLVWGKLGRYPPWPGKIVNPPKDLKKPrgk---kcFFVKFFGTEDHAWIKVEQLKPYHAHKEEMi-KINKGKRFQQ 81
gi 71895849    6 LRQGDLVWGKLGRYPPWPGKIVNPPKDLKKPrgk---kcLFVKFFGTEDHAWIKVEQLKPYHAHKEEMi-KANKGKRFQQ 81
gi 125985109  20 YKPKDLIWAKMKGFTPWPGMIVEPPLDLLTQqrr--antKCVFFFGSRNFAWIEENNIKPFEGPWKEElaKVSKPAAFRH 97
gi 91081069    5 PQIGDLVWAKMKSYSPWPARIVKPGPNSKKQskk---gsHWVYFFGSNNYAWIETPNIKPYEKFKEKFs-GLCKSTPFKD 80
gi 55715842    6 LRIGDLVWGKLGRYPPWPGKVVSPPKDLKKPrgk---kcFFVKFFGTEDHAWIKVEQLKPYHPHKEEMi-KVNKGKRFQQ 81
gi 57529478    6 LRLGDLVWGKLGRYPPWPGKIVNPPKDLKKPrgk---kcFFVKFFGTEDHAWIKVEQLKPYHLHKEEMi-KINKGKRFQQ 81
gi 156542516   5 FKLGDLVWAKMKGFSPWPGRVSTPLANMKKPanpkkgpiYCIFFFGSENYGWIDESNIKPYQEHKEACr-KLCKSEGFKK 83
gi 115666302  44 FDLGDLVWAKMSSFPAWPGRIVKQWKNVKKPagk--kavRFVFFFGTEDHAWVKEESLKHYHEHKATLs-KAGKGAKFTK 120

                 ....*....
Feature 1                 
gi 71297202   82 AVDAVEEFL 90
gi 71895849   82 AVDAVEEFL 90
gi 125985109  98 AMADIDKYI 106
gi 91081069   81 AVDDIEDYI 89
gi 55715842   82 AVDAVEEYL 90
gi 57529478   82 AVDAVEEFL 90
gi 156542516  84 ACDAIENFI 92
gi 115666302 121 AIDAIEEAI 129

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